Determination of tacrine-6-ferulic acid in rat plasma by LC-MS/MS and its application to pharmacokinetics study

Biomedical Chromatography

Volumn 28, Issue 10, 2014, Pages 1352-1359

  Sun, Xiuman ^a   Zhang, Peiting ^b   Pi, Rongbiao ^b   Zhou, Yuting ^b   Deng, Xuejiao ^b   Xie, Zhiyong ^b   Liao, Qiongfeng ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

LC MS MS; Pharmacokinetic study; Tacrine 6 ferulic acid (T6FA)

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; NEURODEGENERATIVE DISEASES; PHARMACOKINETICS;

ALZHEIMERS DISEASE; DRUG CANDIDATES; FERULIC ACIDS; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; PHARMACOKINETIC STUDIES; RAT PLASMA; SIDE EFFECT; TACRINE-6-FERULIC ACID;

RATS;

ACETIC ACID ETHYL ESTER; FERULIC ACID; FORMIC ACID; METHANOL; TACRINE 6 FERULIC ACID; UNCLASSIFIED DRUG; COUMARIC ACID; TACRINE; TACRINE-6-FERULIC ACID;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; DRUG STABILITY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

ANIMALS; CHROMATOGRAPHY, LIQUID; COUMARIC ACIDS; DRUG STABILITY; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TACRINE; TANDEM MASS SPECTROMETRY;

EID: 84908378673     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3173     Document Type: Article

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