Cartilage repair using human embryonic stem cell-derived chondroprogenitors

Stem Cells Translational Medicine

Volumn 3, Issue 11, 2014, Pages 1287-1295

  Cheng, Aixin ^a   Kapacee, Zoher ^a   Peng, Jiang ^b   Lu, Shibi ^b   Lucas, Robert J ^a   Hardingham, Timothy E ^a,c   Kimber, Susan J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Arthritis; Cell transplantation; Embryonic stem cell; Tissue regeneration

Indexed keywords

COLLAGEN TYPE 2; GREEN FLUORESCENT PROTEIN; TRANSCRIPTION FACTOR SOX9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE; CARTILAGE LESION; CHONDROPATHY; CHONDROPROGENITOR; EMBRYONIC STEM CELL; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HYALINE CARTILAGE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; NONHUMAN; NORMAL HUMAN; PLURIPOTENT STEM CELL; RAT; STEM CELL; TISSUE REPAIR; ANIMAL; CARTILAGE CELL; CARTILAGE DISEASES; CELL LINE; INJURIES; METABOLISM; NUDE RAT; PATHOLOGY; STEM CELL TRANSPLANTATION; TRANSPLANTATION; XENOGRAFT;

ANIMALS; CARTILAGE; CARTILAGE DISEASES; CELL LINE; CHONDROCYTES; EMBRYONIC STEM CELLS; HETEROGRAFTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; RATS; RATS, NUDE; STEM CELL TRANSPLANTATION;

EID: 84908374810     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0101     Document Type: Article

References (30)

1. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-895.
2. Filardo G, Kon E, Berruto M, et al. Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: Results at 6 years. Knee 2012; 19:658-663.
3. Kang SW, Yoo SP, Kim BS. Effect of chondrocyte passage number on histological aspects of tissue-engineered cartilage. Biomed Mater Eng 2007;17:269-276.
4. Hettrich CM, Crawford D, Rodeo SA. Cartilage repair: Third-generation cell-based technologies: Basic science, surgical techniques, clinical outcomes. Sports Med Arthrosc 2008;16:230-235.
5. Pelttari K, Winter A, Steck E, et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 2006;54:3254-3266.
6. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
7. Wakitani S, Okabe T, Horibe S, et al. Safety of autologousbone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med 2011;5:146-150.
8. Stolzing A, Jones E, McGonagle D, et al. Age-related changes in human bone marrowderived mesenchymal stem cells: Consequences for cell therapies. Mech Ageing Dev 2008;129:163-173.
9. Oldershaw RA, Baxter MA, Lowe ET, et al. Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol 2010;28:1187-1194.
10. Baxter MA, Camarasa MV, Bates N, et al. Analysis of the distinct functions of growth factors and tissue culture substrates necessary for the long-term self-renewal of human embryonic stem cell lines. Stem Cell Res (Amst) 2009;3:28-38.
11. Pineda S, Pollack A, Stevenson S, et al. A semiquantitative scale for histologic grading of articular cartilage repair. Acta Anat (Basel) 1992;143:335-340.
12. Orth P, Zurakowski D, Wincheringer D, et al. Reliability, reproducibility, and validation of five major histological scoring systems for experimental articular cartilage repair in the rabbit model. Tissue Eng Part C Methods 2012;18:329-339.
13. Ng LJ, Wheatley S, Muscat GE, et al. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol 1997;183: 108-121.
14. Bell DM, Leung KK, Wheatley SC, et al. SOX9 directly regulates the type-II collagen gene. Nat Genet 1997;16:174-178.
15. Lefebvre V, Huang W, Harley VR, et al. SOX9 is a potent activator of the chondrocytespecific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol 1997;17:2336-2346.
16. Bernstin E, Hooper ML, Grandcha S, et al. Alkaline-phosphatase activity in mouse teratoma. Proc Natl Acad Sci USA 1973;70:3899-3903.
17. Liu TM, Guo XM, Tan HS, et al. Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair. Arthritis Rheum 2011; 63:2711-2720.
18. Han Y, Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol 2008;28:4999-5013.
19. Lefebvre V, Behringer RR, de Crombrugghe B. L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage 2001;9(suppl A): S69-S75.
20. Furumatsu T, Tsuda M, Yoshida K, et al. Sox9 and p300 cooperatively regulate chromatinmediated transcription. J Biol Chem 2005;280: 35203-35208.
21. Dvir-Ginzberg M, Gagarina V, Lee EJ, et al. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008;283:36300-36310.
22. Leijten JCH, Emons J, Sticht C, et al. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum 2012;64:3302-3312.
23. Kielty CM, Kwan AP, Holmes DF, et al. Type X collagen, a product of hypertrophic chondrocytes. Biochem J 1985;227:545-554.
24. Ben-David U, Gan QF, Golan-Lev T, et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 2013;12:167-179.
25. Sato M, Uchida K, Nakajima H., et al. Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis. Arthritis Res Ther 2012;14:R31.
26. Jacquet L, Stephenson E, Collins R, et al. Strategy for the creation of clinical grade hESC line banks that HLA-match a target population. EMBO Mol Med 2013;5:10-17.
27. Bilic J, Izpisua Belmonte JC. Concise review: Induced pluripotent stem cells versus embryonic stem cells: Close enough or yet too far apart? STEM CELLS 2012;30:33-41.
28. Wei Y, Zeng W, Wan R, et al. Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix. Eur Cell Mater 2012;23:1-12.
29. Hiramatsu K, Sasagawa S, Outani H, et al. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest 2011;121:640-657.
30. Tew SR, Hardingham TE. Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPKactivation andmRNAstabilization. J Biol Chem 2006;281:39471-39479.