Ethical Focal Points in the International Practice of Deep Brain Stimulation

AJOB Neuroscience

Volumn 5, Issue 4, 2014, Pages 65-80

  Christen, Markus ^a   Ineichen, Christian ^a   Bittlinger, Merlin ^b   Bothe, Hans Werner ^c   Müller, Sabine ^d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

biomedical ethics; center development; deep brain stimulation; movement disorders; patient management; psychiatric disorders

Indexed keywords

EID: 84908365475     PISSN: 21507740     EISSN: 21507759     Source Type: Journal    
DOI: 10.1080/21507740.2014.939380     Document Type: Article

References (73)

1. Abosch, A., L. Timmermann, S. Bartley, 2013. An international survey of deep brain stimulation procedural steps. Stereotactic and Functional Neurosurgery 91: 1–11.
2. Agid, Y., M. Schüpbach, M. Gargiulo, 2006. Neurosurgery in Parkinson's disease: the doctor is happy, the patient less so? Journal of Neural Transmission. Supplementa 70: 409–414.
3. Anderson, R. J., M. A. Frye, O. A. Abulseoud, 2012. Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action. Neuroscience & Biobehavioral Reviews 36(8): 1920–1933.
4. Barbier, J., L. Gabriëls, K. van Laere, and B. Nuttin. 2011. Successful anterior capsulotomy in comorbid anorexia nervosa and obsessive-compulsive disorder: Case report. Neurosurgery 69(3): E745–E751.
5. Bell, E., G. Mathieu, and E. Racine. 2009. Preparing the ethical future of deep brain stimulation. Surgical Neurology 72(6):577–586.
6. Benabid, A. L., P. Pollak, A. Louveau, 1987. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Applied Neurophysiology 50:344–346.
7. Bronstein, J. M., M. Tagliati, R. L. Alterman, 2011. Deep brain stimulation for Parkinson disease: An expert consensus and review of key issues. Archives of Neurology 68(2):165–171.
8. Cacciola, F. 2008. Comment on ‘How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire.’ Parkinsonism & Related Disorders 14(3): 264–265.
9. Charles, P. D., R. M. Dolhun, C. E. Gill, 2012. Deep brain stimulation in early Parkinson's disease: enrollment experience from a pilot trial. Parkinsonism & Related Disorders 18(3): 268–273.
10. Christen, M., and S. Müller. 2013. Expanding DBS indications: Reminder of the consequences of establishing a therapeutic practice. AJOB Neuroscience 4(2): 57–58
11. Christen, M., M. Bittlinge, H. Walter, 2012. Dealing with side effects of deep brain stimulation: Lessons learned from stimulating the STN. AJOB Neuroscience 3(1): 37–43.
12. Christen, M., and S. Müller. 2012. Current status and future challenges of deep brain stimulation in Switzerland. Swiss Medical Weekly 142: w13570.
13. Christen, M., and S. Müller. 2011. Single cases promote knowledge transfer in the field of DBS. Frontiers in Integrative Neuroscience 5:13.
14. Clausen, J. 2010. Ethical brain stimulation—Neuroethics of deep brain stimulation in research and clinical practice. European Journal of Neuroscience 32(7): 1152–1162.
15. Costa, P. T., and R. R. McCrae. 1992. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual. Odessa, FL: Psychological Assessment Resources, 1992.
16. D’Astous, M., S. Cottin, M. Roy, 2013. Bilateral stereotactic anterior capsulotomy for obsessive-compulsive disorder: Long-term follow-up. Journal of Neurology, Neurosurgery, and Psychiatry. doi:10.1136/jnnp-2012-303826
17. De Koning, P. P., M. Figee, P. van den Munckhof, 2011. Current status of deep brain stimulation for obsessive-compulsive disorder: A clinical review of different targets. Current Psychiatry Reports 13: 274–282.
18. De Lau, L. M. L., and M. M. B. Breteler. 2006. Epidemiology of Parkinson's disease. Lancet Neurology 5: 525–535.
19. Deuschl, G., C. Schade-Brittinger, P. Krack, 2006. A randomized trial of deep-brain stimulation for Parkinson's disease. New England Journal of Medicine 355: 896–908.
20. Feldman, R. P., R. L. Alterman, and J. T. Goodrich. 2001. Contemporary psychosurgery and a look to the future. Journal of Neurosurgery 95: 944–956
21. Fins, J. J., G. S. Dorfman, and J. J. Pancrazio. 2012. Challenges to deep brain stimulation: a pragmatic response to ethical, fiscal, and regulatory concerns. Annals of the New York Academy of Science 1265: 80–90.
22. Fins, J. J., H. S. Mayberg, B. Nuttin, 2011. Misuse of the humanitarian device exemption in deep brain stimulation for obsessive-compulsive disorder. Health Affairs 30: 2302–2311.
23. Fontaine, D., A. Deudon, J. J. Lemaire, 2013. Symptomatic treatment of memory decline in Alzheimer's disease by deep brain stimulation: A feasibility study. Journal of Alzheimers Disorder 34(1): 315–323.
24. Franzini, A., G. Broggi, R. Cordella, 2012. Deep-brain stimulation for aggressive and disruptive behavior. World Neurosurgery 80(3–4): S29.e11-4.
25. Goodman, W. K., and R. L. Alterman. 2012. Deep brain stimulation for intractable psychiatric disorders. Annual Review of Medicine 63: 511–524.
26. Greenberg, B. D., S. L. Rauch, and S. N. Haber. 2010. Invasive circuitry-based neurotherapeutics: Stereotactic ablation and deep brain stimulation. Neuropsychopharmacology 35: 317–336.
27. Halpern, C. H., N. Torres, H. I. Hurtig, 2011. Expanding applications of deep brain stimulation: A potential therapeutic role in obesity and addiction management. Acta Neurochirurgica 153: 2293–2306.
28. Hardenacke, K., J. Kuhn, D. Lenartz, 2013. Stimulate or degenerate: Deep brain stimulation of the nucleus basalis Meynert in Alzheimer dementia. World Neurosurgery 80(3–4): S27.e35-43.
29. Hariz, M. I., P. Blomstedt, and L. Zrinzo. 2010. Deep brain stimulation between 1947 and 1987: The untold story. Neurosurgical Focus 29(2): E1.
30. Hariz, M. I., S. Rehncrona, N. P. Quinn, 2008. Multicenter study on deep brain stimulation in Parkinson's disease: an independent assessment of reported adverse events at 4 years. Movement Disorders 23(3): 416–421.
31. Hescham, S., L. W. Lim, A. Jahanshahi, 2013. Deep brain stimulation in dementia-related disorders. Neuroscience and Biobehavioral Reviews 37(10 Pt 2): 2666–2675.
32. Holtzheimer, P. E., and H. S. Mayberg. 2011. Deep brain stimulation for psychiatric disorders. Annual Review of Neuroscience 34: 289–307.
33. Jolesz, F. A., and N. J. McDannold. 2014. Magnetic resonance-guided focused ultrasound: A new technology for clinical neurosciences. Neurologic Clinics 32(1): 253–269.
34. Katz, M., C. Kilbane, J. Rosengard, 2011. Referring patients for deep brain stimulation. An improving practice. Archives of Neurology 68(8): 1027–1032.
35. Kleiner-Fisman, G., J. Herzog, D. N. Fisman, 2006. Subthalamic nucleus deep brain stimulation: Summary and meta-analysis of outcome. Movement Disorders 21(Suppl. 14): S290–S304.
36. Kluger, B. M., K. D. Foote, C. E. Jacobson, and M. S. Okun. 2011. Lessons learned from a large single center cohort of patients referred for DBS management. Parkinsonism & Related Disorders 17(4): 236–239.
37. Kondziolka, D., J. C. Flickinger, and R. Hudak. 2011. Results following Gamma Knife radiosurgical anterior capsulotomies for obsessive compulsive disorder. Neurosurgery 68: 28–33.
38. Krauss, J. K., B. Broggi, H. J. Reulen, 2009. Training chart in movement disorders surgery added competence. Acta Neurochirurgica 151: 1505–1509.
39. Kubu, C. S., and P. J. Ford. 2012. Beyond mere symptom relief in deep brain stimulation: an ethical obligation for multi-faceted assessment of outcome. AJOB Neuroscience 3(1): 44–49.
40. Laxton, A. W., and A. M. Lozano. 2013. Deep brain stimulation for the treatment of Alzheimer disease and dementias. World Neurosurgery 80(3–4): S28.e1-8.
41. Laxton, A. W., D. F. Tang-Wai, M. P. McAndrews, 2010. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Annals of Neurology 68(4): 521–534.
42. Leiphart, J. W., and F. H. Valone. 2010. Stereotactic lesions for the treatment of psychiatric disorders. Journal of Neurosurgery 113: 1204–1211.
43. Lieberman, I., J. Herndon, J. Hahn, 2008. Surgical innovation and ethical dilemmas: A panel discussion. Cleveland Clinic Journal of Medicine 75 (Suppl. 6): S13–S21.
44. Lipsman, N., P. Giacobbe, M. Bernstein, and A. M. Lozano. 2012. Informed consent for clinical trials of deep brain stimulation in psychiatric disease: Challenges and implications for trial design. Journal of Medical Ethics 38(2): 107–111.
45. Lipsman, N., M. L. Schwartz, Y. Huang, 2013b. MR-guided focused ultrasound thalamotomy for essential tremor: A proof-of-concept study. Lancet Neurology 12(5): 462–468.
46. Lipsman, N., D. B. Woodside, P. Giacobbe, 2013a. Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: A phase 1 pilot trial. Lancet 381(9875): 1361–1370.
47. Luigjes, J., W. van den Brink, M. Feenstra, 2012. Deep brain stimulation in addiction: A review of potential brain targets. Molecular Psychiatry 17(6): 572–583.
48. Morgante, L., F. Morgante, and E. Moro. 2007. How many Parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire. Parkinsonism & Related Disorders 13(8): 528–531.
49. Müller, S., and M. Christen. 2011. Deep brain stimulation in Parkinsonian patients—Ethical evaluation of cognitive, affective, and behavioral sequelae. AJOB Neuroscience 2(1): 3–13.
50. Müller-Vahl, K. R. 2013. Surgical treatment of Tourette syndrome. Neuroscience and Biobehavioral Reviews 37: 1178–1185.
51. Nuttin, B., H. Wu, H. Mayberg, 2014. Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders. Journal of Neurology, Neurosurgery, and Psychiatry. doi:10.1136/jnnp-2013-306580
52. Organization for Economic Coopereation and Development. 2012. OECD obesity update. http://www.oecd.org/health/49716427.pdf (accessed March 12, 2014).
53. Oyama, G., R. L. Rodriguez, J. D. Jones, 2012. Selection of deep brain stimulation candidates in private neurology practices: Referral may be simpler than a computerized triage system. Neuromodulation 15: 246–250.
54. Rabins, P., B. S. Appleby, J. Brandt, 2009. Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior and thought. Archives of General Psychiatry 66(9): 931–937.
55. Research and Markets. 2013. Global deep brain stimulator market 2012–2016. http://www.researchandmarkets.com/publication/mli3pqi/global_deep_brain_stimulator_market_20122016 (accessed January 3, 2014).
56. Salma, A., M. Vasilakis, and P. T. Tracy. 2014. Deep brain stimulation for cognitive disorders: insights into targeting nucleus basalis of Meynert in Alzheimer dementia. World Neurosurgery 81(1): e4–e5.
57. Schläpfer, T. E., B. H. Bewernick, S. Kayser, 2013. Rapid effects of deep brain stimulation for treatment-resistant major depression. Biological Psychiatry. doi:10.1016/j.biopsych.2013.01.034
58. Schläpfer, T. E., and J. J. Fins. 2010. Deep brain stimulation and the neuroethics of responsible publishing: When one is not enough. Journal of the American Medical Association 303(8): 775–776.
59. Schüpbach, W. M., J. Rau, K. Knudsen, 2013. Neurostimulation for Parkinson's disease with early motor complications. New England Journal of Medicine 368(7): 610–622.
60. Setiawan, M., S. Kraft, K. Doig, 2006. Referrals for movement disorder surgery: under-representation of females and reasons for refusal. Canadian Journal of Neurological Sciences 33: 53–57.
61. Siegfried, J. 1986. Effect of stimulation of the sensory nucleus of the thalamus on dyskinesia and spasticity. Revue Neurologique (Paris) 142(4): 380–383.
62. Südmeyer, M., J. Volkmann, L. Wojtecki, 2012. Tiefe Hirnstimulation - Erwartungen und Bedenken. Bundesweite Fragebogenstudie mit Parkinson-Patienten und deren Angehörigen. Nervenarzt 83(4): 481–486.
63. Temel, Y., A. Kessel, S. Tan, 2006. Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: A systematic review. Parkinsonism & Related Disorders 12(5): 265–272.
64. Thomas, L., D. Kessler, J. Campbell, 2013. Prevalence of treatment-resistant depression in primary care: cross-sectional data. British Journal of General Practice 63(617): e852–e858.
65. Videnovic, A., and L. V. Metman. 2008. Deep brain stimulation for Parkinson's disease: prevalence of adverse events and need for standardized reporting. Movement Disorders 23(3): 343–349.
66. Volkmann, J., C. Daniels, and K. Witt. 2010. Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease. Nature Reviews Neurology 6: 487–498.
67. Voon, V., C. Kubu, P. Krack, 2006. Deep brain stimulation: Neuropsychological and neuropsychiatric issues. Movement Disorders 21(Suppl. 14): S305–S326.
68. Whiting, D. M., N. D. Tomycz, J. Bailes, 2013. Lateral hypothalamic area deep brain stimulation for refractory obesity: A pilot study with preliminary data on safety, body weight, and energy metabolism. Journal of Neurosurgery 119: 56–63.
69. Wider, C., C. Pollo, J. Bloch, 2008. Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation. Parkinsonism & Related Disorders 14(2): 114–119.
70. Witt, K., C. Daniels, J. Reiff, 2008. Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson´s disease: A randomised, multicentre study. Lancet Neurology 7(7): 605–614.
71. Witt, K., C. Daniels, and J. Volkmann. 2012. Factors associated with neuropsychiatric side effects after STN-DBS in Parkinson's disease. Parkinsonism & Related Disorders 18(Suppl. 1): S168–S170.
72. Woopen, C., L. Timmermann, and J. Kuhn. 2012. An ethical framework for outcome assessment in psychiatric DBS. AJOB Neuroscience 3(1): 50–55.
73. World Health Organization. 2012. Dementia: A public health priority. http://www.who.int/mental_health/publications/dementia_report_2012/en (accessed March 12, 2014).