A sensitive and selective method for the quantitative analysis of miglitol in rat plasma using unique solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry

Biomedical Chromatography

Volumn 28, Issue 10, 2014, Pages 1423-1429

  Mizuno Yasuhira, Akiko ^a   Kinoshita, Kohnosuke ^a   Jingu, Shigeji ^a   Yamaguchi, Jun Ichi ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

LC MS MS; Miglitol; Monomeric sugar; Plasma; Quantification; SPE

Indexed keywords

AMIDES; BODY FLUIDS; ELECTROSPRAY IONIZATION; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION; POSITIVE IONS;

LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MIGLITOL; MONOMERIC SUGARS; QUANTIFICATION; RAT PLASMA; SOLID-PHASE EXTRACTION; SPE;

RATS;

AMIDE; MIGLITOL; STABLE ISOTOPE; 1 DEOXYNOJIRIMYCIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CALIBRATION; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA CLEARANCE; PRECIPITATION; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY; VOLUME OF DISTRIBUTION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; TEMPERATURE;

1-DEOXYNOJIRIMYCIN; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 84908363823     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3185     Document Type: Article

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