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Volumn 59, Issue , 2014, Pages 125-131

L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: A double-blind, placebo-controlled, randomized trial

Author keywords

Clinical trial; L lysine; Nitric oxide; PANSS; Schizophrenia

Indexed keywords

LYSINE; PLACEBO; RISPERIDONE; NEUROLEPTIC AGENT;

EID: 84908361172     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.08.016     Document Type: Article
Times cited : (27)

References (40)
  • 1
    • 0027394523 scopus 로고
    • Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development
    • Akbarian S., Bunney W.E., Potkin S.G., Wigal S.B., Hagman J.O., Sandman C.A., et al. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry 1993, 50:169-177.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 169-177
    • Akbarian, S.1    Bunney, W.E.2    Potkin, S.G.3    Wigal, S.B.4    Hagman, J.O.5    Sandman, C.A.6
  • 2
    • 0027405968 scopus 로고
    • Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development
    • Akbarian S., Vinuela A., Kim J.J., Potkin S.G., Bunney W.E., Jones E.G. Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. Arch Gen Psychiatry 1993, 50:178-187.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 178-187
    • Akbarian, S.1    Vinuela, A.2    Kim, J.J.3    Potkin, S.G.4    Bunney, W.E.5    Jones, E.G.6
  • 3
    • 1842556339 scopus 로고    scopus 로고
    • Expression of nNOS and soluble guanylate cyclase in schizophrenic brain
    • Baba H., Suzuki T., Arai H., Emson P.C. Expression of nNOS and soluble guanylate cyclase in schizophrenic brain. Neuroreport 2004, 15:677-680.
    • (2004) Neuroreport , vol.15 , pp. 677-680
    • Baba, H.1    Suzuki, T.2    Arai, H.3    Emson, P.C.4
  • 4
    • 2442657787 scopus 로고    scopus 로고
    • L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs
    • Carter B.W., Chicoine L.G., Nelin L.D. l-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs. Pediatr Res 2004, 55:979-987.
    • (2004) Pediatr Res , vol.55 , pp. 979-987
    • Carter, B.W.1    Chicoine, L.G.2    Nelin, L.D.3
  • 5
    • 20444376911 scopus 로고    scopus 로고
    • Manual for the extrapyramidal symptom rating scale (ESRS)
    • Chouinard G., Margolese H.C. Manual for the extrapyramidal symptom rating scale (ESRS). Schizophr Res 2005, 76:247-265.
    • (2005) Schizophr Res , vol.76 , pp. 247-265
    • Chouinard, G.1    Margolese, H.C.2
  • 8
    • 84888130707 scopus 로고    scopus 로고
    • N-acetylcysteine as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study
    • Farokhnia M., Azarkolah A., Adinehfar F., Khodaie-Ardakani M.R., Hosseini S.M., Yekehtaz H., et al. N-acetylcysteine as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study. Clin Neuropharmacol 2013, 36:185-192.
    • (2013) Clin Neuropharmacol , vol.36 , pp. 185-192
    • Farokhnia, M.1    Azarkolah, A.2    Adinehfar, F.3    Khodaie-Ardakani, M.R.4    Hosseini, S.M.5    Yekehtaz, H.6
  • 9
    • 84892814107 scopus 로고    scopus 로고
    • Adouble-blind, placebo controlled, randomized trial of riluzole as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia
    • Farokhnia M., Sabzabadi M., Pourmahmoud H., Khodaie-Ardakani M.R., Hosseini S.M., Yekehtaz H., et al. Adouble-blind, placebo controlled, randomized trial of riluzole as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia. Psychopharmacol Berl 2014, 231:533-542.
    • (2014) Psychopharmacol Berl , vol.231 , pp. 533-542
    • Farokhnia, M.1    Sabzabadi, M.2    Pourmahmoud, H.3    Khodaie-Ardakani, M.R.4    Hosseini, S.M.5    Yekehtaz, H.6
  • 11
    • 0031026483 scopus 로고    scopus 로고
    • The metabolic roles, pharmacology, and toxicology of lysine
    • Flodin N.W. The metabolic roles, pharmacology, and toxicology of lysine. JAm Coll Nutr 1997, 16:7-21.
    • (1997) J Am Coll Nutr , vol.16 , pp. 7-21
    • Flodin, N.W.1
  • 12
    • 0023196958 scopus 로고
    • Success of l-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis
    • Griffith R.S., Walsh D.E., Myrmel K.H., Thompson R.W., Behforooz A. Success of l-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987, 175:183-190.
    • (1987) Dermatologica , vol.175 , pp. 183-190
    • Griffith, R.S.1    Walsh, D.E.2    Myrmel, K.H.3    Thompson, R.W.4    Behforooz, A.5
  • 14
    • 78649907123 scopus 로고    scopus 로고
    • Assessment of pharmacotherapy for negative symptoms of schizophrenia
    • Hanson E., Healey K., Wolf D., Kohler C. Assessment of pharmacotherapy for negative symptoms of schizophrenia. Curr Psychiatry Rep 2010, 12:563-571.
    • (2010) Curr Psychiatry Rep , vol.12 , pp. 563-571
    • Hanson, E.1    Healey, K.2    Wolf, D.3    Kohler, C.4
  • 15
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987, 13:261-276.
    • (1987) Schizophr Bull , vol.13 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 16
    • 84900095329 scopus 로고    scopus 로고
    • Minocycline add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized double-blind placebo-controlled study
    • Khodaie-Ardakani M.R., Mirshafiee O., Farokhnia M., Tajdini M., Hosseini S.M., Modabbernia A., et al. Minocycline add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized double-blind placebo-controlled study. Psychiatry Res 2014.
    • (2014) Psychiatry Res
    • Khodaie-Ardakani, M.R.1    Mirshafiee, O.2    Farokhnia, M.3    Tajdini, M.4    Hosseini, S.M.5    Modabbernia, A.6
  • 17
    • 0034917120 scopus 로고    scopus 로고
    • The nitric oxide synthase inhibitor, L-NAME, block phencyclidine-induced disruption of prepulse inhibition in mice
    • Klamer D., Engel J.A., Svensson L. The nitric oxide synthase inhibitor, L-NAME, block phencyclidine-induced disruption of prepulse inhibition in mice. Psychopharmacol Berl 2001, 156:182-186.
    • (2001) Psychopharmacol Berl , vol.156 , pp. 182-186
    • Klamer, D.1    Engel, J.A.2    Svensson, L.3
  • 18
    • 1642361722 scopus 로고    scopus 로고
    • Phencyclidine-induced behaviour in mice prevented by methylene blue
    • Klamer D., Engel J.A., Svensson L. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol 2004, 94:65-72.
    • (2004) Basic Clin Pharmacol Toxicol , vol.94 , pp. 65-72
    • Klamer, D.1    Engel, J.A.2    Svensson, L.3
  • 19
    • 50549088246 scopus 로고    scopus 로고
    • Reduced plasma nitric oxide metabolites before and after antipsychotic treatment in patients with schizophrenia compared to controls
    • Lee B.H., Kim Y.K. Reduced plasma nitric oxide metabolites before and after antipsychotic treatment in patients with schizophrenia compared to controls. Schizophr Res 2008, 104:36-43.
    • (2008) Schizophr Res , vol.104 , pp. 36-43
    • Lee, B.H.1    Kim, Y.K.2
  • 20
    • 16544374077 scopus 로고    scopus 로고
    • Multiplicity-adjusted sample size requirements: a strategy to maintain statistical power with Bonferroni adjustments
    • Leon A.C. Multiplicity-adjusted sample size requirements: a strategy to maintain statistical power with Bonferroni adjustments. JClin Psychiatry 2004, 65:1511-1514.
    • (2004) J Clin Psychiatry , vol.65 , pp. 1511-1514
    • Leon, A.C.1
  • 21
    • 77649112679 scopus 로고    scopus 로고
    • Adouble-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y., Mendlovich S., Riwkes S., Braw Y., Levkovitch-Verbin H., Gal G., et al. Adouble-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. JClin Psychiatry 2010, 71:138-149.
    • (2010) J Clin Psychiatry , vol.71 , pp. 138-149
    • Levkovitz, Y.1    Mendlovich, S.2    Riwkes, S.3    Braw, Y.4    Levkovitch-Verbin, H.5    Gal, G.6
  • 22
    • 0028072239 scopus 로고
    • Amino acids differentially inhibit the l-[3H]arginine transport and nitric oxide synthase in rat brain synaptosomes
    • Lopes M.C., Cardoso S.A., Schousboe A., Carvalho A.P. Amino acids differentially inhibit the l-[3H]arginine transport and nitric oxide synthase in rat brain synaptosomes. Neurosci Lett 1994, 181:1-4.
    • (1994) Neurosci Lett , vol.181 , pp. 1-4
    • Lopes, M.C.1    Cardoso, S.A.2    Schousboe, A.3    Carvalho, A.P.4
  • 24
    • 84873053697 scopus 로고    scopus 로고
    • Intranasal oxytocin as an adjunct to risperidone in patients with schizophrenia : an 8-week, randomized, double-blind, placebo-controlled study
    • Modabbernia A., Rezaei F., Salehi B., Jafarinia M., Ashrafi M., Tabrizi M., et al. Intranasal oxytocin as an adjunct to risperidone in patients with schizophrenia : an 8-week, randomized, double-blind, placebo-controlled study. CNS Drugs 2013, 27:57-65.
    • (2013) CNS Drugs , vol.27 , pp. 57-65
    • Modabbernia, A.1    Rezaei, F.2    Salehi, B.3    Jafarinia, M.4    Ashrafi, M.5    Tabrizi, M.6
  • 25
    • 33750625280 scopus 로고    scopus 로고
    • Pharmacological treatment of primary negative symptoms in schizophrenia: a systematic review
    • Murphy B.P., Chung Y.C., Park T.W., McGorry P.D. Pharmacological treatment of primary negative symptoms in schizophrenia: a systematic review. Schizophr Res 2006, 88:5-25.
    • (2006) Schizophr Res , vol.88 , pp. 5-25
    • Murphy, B.P.1    Chung, Y.C.2    Park, T.W.3    McGorry, P.D.4
  • 26
    • 84881233122 scopus 로고    scopus 로고
    • Aplacebo-controlled study of tropisetron added to risperidone for the treatment of negative symptoms in chronic and stable schizophrenia
    • Noroozian M., Ghasemi S., Hosseini S.M., Modabbernia A., Khodaie-Ardakani M.R., Mirshafiee O., et al. Aplacebo-controlled study of tropisetron added to risperidone for the treatment of negative symptoms in chronic and stable schizophrenia. Psychopharmacol Berl 2013, 228:595-602.
    • (2013) Psychopharmacol Berl , vol.228 , pp. 595-602
    • Noroozian, M.1    Ghasemi, S.2    Hosseini, S.M.3    Modabbernia, A.4    Khodaie-Ardakani, M.R.5    Mirshafiee, O.6
  • 27
    • 34247640205 scopus 로고    scopus 로고
    • The amino acid l-lysine blocks the disruptive effect of phencyclidine on prepulse inhibition in mice
    • Palsson E., Fejgin K., Wass C., Engel J.A., Svensson L., Klamer D. The amino acid l-lysine blocks the disruptive effect of phencyclidine on prepulse inhibition in mice. Psychopharmacology 2007, 192:9-15.
    • (2007) Psychopharmacology , vol.192 , pp. 9-15
    • Palsson, E.1    Fejgin, K.2    Wass, C.3    Engel, J.A.4    Svensson, L.5    Klamer, D.6
  • 28
    • 48049092376 scopus 로고    scopus 로고
    • Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition
    • Palsson E., Fejgin K., Wass C., Klamer D. Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition. Eur J Pharmacol 2008, 590:212-216.
    • (2008) Eur J Pharmacol , vol.590 , pp. 212-216
    • Palsson, E.1    Fejgin, K.2    Wass, C.3    Klamer, D.4
  • 29
    • 1942504903 scopus 로고    scopus 로고
    • Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study
    • Ramirez J., Garnica R., Boll M.C., Montes S., Rios C. Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study. Schizophr Res 2004, 68:357-361.
    • (2004) Schizophr Res , vol.68 , pp. 357-361
    • Ramirez, J.1    Garnica, R.2    Boll, M.C.3    Montes, S.4    Rios, C.5
  • 30
    • 0034193104 scopus 로고    scopus 로고
    • Is agmatine a novel neurotransmitter in brain?
    • Reis D.J., Regunathan S. Is agmatine a novel neurotransmitter in brain?. Trends Pharmacol Sci 2000, 21:187-193.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 187-193
    • Reis, D.J.1    Regunathan, S.2
  • 31
    • 84877583223 scopus 로고    scopus 로고
    • Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized, double-blind, placebo-controlled study
    • Rezaei F., Mohammad-Karimi M., Seddighi S., Modabbernia A., Ashrafi M., Salehi B., et al. Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized, double-blind, placebo-controlled study. JClin Psychopharmacol 2013, 33:336-342.
    • (2013) J Clin Psychopharmacol , vol.33 , pp. 336-342
    • Rezaei, F.1    Mohammad-Karimi, M.2    Seddighi, S.3    Modabbernia, A.4    Ashrafi, M.5    Salehi, B.6
  • 32
    • 0036024257 scopus 로고    scopus 로고
    • Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia
    • Shinkai T., Ohmori O., Hori H., Nakamura J. Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia. Mol Psychiatry 2002, 7:560-563.
    • (2002) Mol Psychiatry , vol.7 , pp. 560-563
    • Shinkai, T.1    Ohmori, O.2    Hori, H.3    Nakamura, J.4
  • 34
    • 77956864079 scopus 로고    scopus 로고
    • Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis
    • Singh S.P., Singh V., Kar N., Chan K. Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis. Br J Psychiatry 2010, 197:174-179.
    • (2010) Br J Psychiatry , vol.197 , pp. 174-179
    • Singh, S.P.1    Singh, V.2    Kar, N.3    Chan, K.4
  • 35
    • 10944220959 scopus 로고    scopus 로고
    • Serum nitric oxide metabolite levels and the effect of antipsychotic therapy in schizophrenia
    • Taneli F., Pirildar S., Akdeniz F., Uyanik B.S., Ari Z. Serum nitric oxide metabolite levels and the effect of antipsychotic therapy in schizophrenia. Arch Med Res 2004, 35:401-405.
    • (2004) Arch Med Res , vol.35 , pp. 401-405
    • Taneli, F.1    Pirildar, S.2    Akdeniz, F.3    Uyanik, B.S.4    Ari, Z.5
  • 36
    • 79955086645 scopus 로고    scopus 로고
    • L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot study
    • Wass C., Klamer D., Katsarogiannis E., Palsson E., Svensson L., Fejgin K., et al. l-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, randomized, cross-over pilot study. BMC Med 2011, 9:40.
    • (2011) BMC Med , vol.9 , pp. 40
    • Wass, C.1    Klamer, D.2    Katsarogiannis, E.3    Palsson, E.4    Svensson, L.5    Fejgin, K.6
  • 37
    • 0020317553 scopus 로고
    • Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts
    • White M.F., Gazzola G.C., Christensen H.N. Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts. JBiol Chem 1982, 257:4443-4449.
    • (1982) J Biol Chem , vol.257 , pp. 4443-4449
    • White, M.F.1    Gazzola, G.C.2    Christensen, H.N.3
  • 38
    • 0035081701 scopus 로고    scopus 로고
    • Arginine metabolism and the synthesis of nitric oxide in the nervous system
    • Wiesinger H. Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol 2001, 64:365-391.
    • (2001) Prog Neurobiol , vol.64 , pp. 365-391
    • Wiesinger, H.1
  • 39
    • 0033946125 scopus 로고    scopus 로고
    • Characterization of l-arginine transporters in rat renal inner medullary collecting duct
    • Wu F., Cholewa B., Mattson D.L. Characterization of l-arginine transporters in rat renal inner medullary collecting duct. Am J Physiol Regul Integr Comp Physiol 2000, 278:R1506-R1512.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.278 , pp. R1506-R1512
    • Wu, F.1    Cholewa, B.2    Mattson, D.L.3
  • 40
    • 33847058371 scopus 로고    scopus 로고
    • Increased levels of nitric oxide, cortisol and adrenomedullin in patients with chronic schizophrenia
    • Yilmaz N., Herken H., Cicek H.K., Celik A., Yurekli M., Akyol O. Increased levels of nitric oxide, cortisol and adrenomedullin in patients with chronic schizophrenia. Med Princ Pract 2007, 16:137-141.
    • (2007) Med Princ Pract , vol.16 , pp. 137-141
    • Yilmaz, N.1    Herken, H.2    Cicek, H.K.3    Celik, A.4    Yurekli, M.5    Akyol, O.6


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