Mutational analysis of essential septins reveals a role for septin-mediated signaling in filamentation

Eukaryotic Cell

Volumn 13, Issue 11, 2014, Pages 1403-1410

  Blankenship, Jill R ^a,b   Cheng, Shaoji ^c   Woolford, Carol A ^b   Xu, Wenjie ^b   Johnson, Tanner M ^a   David Rogers, P ^d   Fanning, Saranna ^b   Hong Nguyen, M ^c   Clancy, Cornelius J ^c   Mitchell, Aaron P ^b  

^a UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA BINDING PROTEIN; EFG1 PROTEIN, CANDIDA ALBICANS; FUNGAL PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SEPTIN; TPK1 PROTEIN, S CEREVISIAE; TRANSCRIPTION FACTOR;

ANIMAL; BIOSYNTHESIS; CANDIDA ALBICANS; CANDIDIASIS; CELL DIVISION; CELL WALL; CYTOSKELETON; DNA MUTATIONAL ANALYSIS; FUNGUS HYPHAE; GENETICS; GROWTH, DEVELOPMENT AND AGING; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MOUSE; PATHOGENICITY; PATHOLOGY; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CELL CYCLE PROTEINS; CELL DIVISION; CELL WALL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETON; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; HYPHAE; MALE; MICE; MICE, INBRED ICR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEPTINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84908352079     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00127-14     Document Type: Article

References (23)

1. Pfaller MA, Diekema DJ. 2007. Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 20:133–163. http://dx.doi.org/10.1128/CMR.00029-06.
2. Lo H-J, Köhler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939–949. http://dx.doi.org/10.1016/S0092-8674(00)80358-X.
3. Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. 2003. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot. Cell 2:1053–1060. http://dx.doi.org/10.1128/EC.2.5.1053-1060.2003.
4. Hernandez-Rodriguez Y, Momany M. 2012. Posttranslational modifications and assembly of septin heteropolymers and higher-order structures. Curr. Opin. Microbiol. 15:660–668. http://dx.doi.org/10.1016/j.mib.2012.09.007.
5. Longtine MS, Bi E. 2003. Regulation of septin organization and function in yeast. Trends Cell Biol. 13:403–409. http://dx.doi.org/10.1016/S0962-8924(03)00151-X.
6. McMurray MA, Thorner J. 2008. Septin stability and recycling during dynamic structural transitions in cell division and development. Curr. Biol. 18:1203–1208. http://dx.doi.org/10.1016/j.cub.2008.07.020.
7. Warenda A, Konopka J. 2002. Septin function in Candida albicans morphogenesis. Mol. Biol. Cell 13:2732–2746. http://dx.doi.org/10.1091/mbc.E02-01-0013.
8. Gonzalez-Novo A, Correa-Bordes J, Labrador L, Sanchez M, Vazquez de Aldana CR, Jimenez J. 2008. Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth. Mol. Biol. Cell 19:1509–1518. http://dx.doi.org/10.1091/mbc.E07-09-0876.
9. Blankenship JR, Fanning S, Hamaker JJ, Mitchell AP. 2010. An extensive circuitry for cell wall regulation in Candida albicans. PLoS Pathog. 6:e1000752. http://dx.doi.org/10.1371/journal.ppat.1000752.
10. Li L, Zhang C, Konopka JB. 2012. A Candida albicans temperature-sensitive cdc12-6 mutant identifies roles for septins in selection of sites of germ tube formation and hyphal morphogenesis. Eukaryot. Cell 11:1210–1218. http://dx.doi.org/10.1128/EC.00216-12.
11. Li CR, Yong JY, Wang Y., Wang Y. 2012. CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4. J. Cell Sci. 125:2533–2543. http://dx.doi.org/10.1242/jcs.104497.
12. Wang Y. 2009. CDKs and the yeast-hyphal decision. Curr. Opin. Micro-biol. 12:644–649. http://dx.doi.org/10.1016/j.mib.2009.09.002.
13. Wilson RB, Davis D, Mitchell AP. 1999. Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol. 181:1868–1874.
14. Enloe B, Diamond A, Mitchell AP. 2000. A single-transformation gene function test in diploid Candida albicans. J. Bacteriol. 182:5730–5736. http://dx.doi.org/10.1128/JB.182.20.5730-5736.2000.
15. Spreghini E, Davis DA, Subaran R, Kim M, Mitchell AP. 2003. Roles of Candida albicans Dfg5p and Dcw1p cell surface proteins in growth and hypha formation. Eukaryot. Cell 2:746–755. http://dx.doi.org/10.1128/EC.2.4.746-755.2003.
16. Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Liebundguth N, Lockhart DJ, Lucau-Danila A, Lussier M, M’Rabet N, Menard P, Mittmann M, Pai C, Rebischung C, Revuelta JL, Riles L, Roberts CJ, Ross-MacDonald P, Scherens B, Snyder M, Sookhai-Mahadeo S, Storms RK, Veronneau S, Voet M, Volckaert G, Ward TR, Wysocki R, Yen GS, Yu K, Zimmermann K, Philippsen P, Johnston M, Davis RW. 1999. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901–906. http://dx.doi.org/10.1126/science.285.5429.901.
17. Liu TT, Znaidi S, Barker KS, Xu L, Homayouni R, Saidane S, Morschhauser J, Nantel A, Raymond M, Rogers PD. 2007. Genome-wide expression and location analyses ofthe Candida albicans Tac1p regu-lon. Eukaryot. Cell 6:2122–2138. http://dx.doi.org/10.1128/EC.00327-07.
18. Warenda AJ, Kauffman S, Sherrill TP, Becker JM, Konopka JB. 2003. Candida albicans septin mutants are defective for invasive growth and virulence. Infect. Immun. 71:4045–4051. http://dx.doi.org/10.1128/IAI.71.7.4045-4051.2003.
19. Bockmuhl DP, Krishnamurthy S, Gerads M, Sonneborn A, Ernst JF. 2001. Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans. Mol. Microbiol. 42:1243–1257. http://dx.doi.org/10.1046/j.1365-2958.2001.02688.x.
20. Fanning S, Xu W, Beaurepaire C, Suhan JP, Nantel A, Mitchell AP. 2012. Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1. Mol. Microbiol. 86:284–302. http://dx.doi.org/10.1111/j.1365-2958.2012.08193.x.
21. Mostowy S, Cossart P. 2012. Septins: the fourth component of the cyto-skeleton. Nat. Rev. Mol. Cell. Biol. 13:183–194. http://dx.doi.org/10.1038/nrm3284.
22. Badrane H, Nguyen MH, Blankenship JR, Cheng S, Hao B, Mitchell AP, Clancy CJ. 2012. Rapid redistribution of phosphatidylinositol-(4,5)-bisphosphate and septins during the Candida albicans response to caspo-fungin. Antimicrob. Agents Chemother. 56:4614–4624. http://dx.doi.org/10.1128/AAC.00112-12.
23. Davis D, Edwards JE, Jr, Mitchell AP, Ibrahim AS. 2000. Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect. Immun. 68:5953–5959. http://dx.doi.org/10.1128/IAI.68.10.5953-5959.2000.