Platelet function monitoring in elderly patients on prasugrel after stenting for an acute coronary syndrome: Design of the randomized antarctic study

American Heart Journal

Volumn 168, Issue 5, 2014, Pages 674-681.e1

  Cayla, Guillaume ^a,s   Cuisset, Thomas ^b   Silvain, Johanne ^c,s   Henry, Patrick ^d   Leclercq, Florence ^e   Carrié, Didier ^f   Etienne, Christophe Saint ^g   Belle, Loic ^h   Rangé, Grégoire ⁱ   Pouillot, Christophe ^j   Varenne, Olivier ^k   Van Belle, Eric ^l   Boueri, Ziad ^m   Motreff, Pascal ⁿ   Elhadad, Simon ^o   Delarche, Nicolas ^p   El Mahmoud, Rami ^q   Vicaut, Eric ^r   Collet, Jean Philippe ^c,s   Montalescot, Gilles ^c,s  

^a DEPARTMENT OF NEUROLOGY   (France)

^b TIMONE HOSPITAL   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e MONTPELLIER UNIVERSITY HOSPITAL   (France)

^f TOULOUSE UNIVERSITY HOSPITAL   (France)

^g UNIVERSITY HOSPITAL OF TOURS   (France)

^h Service de Cardiologie CH   (France)

ⁱ Louis Pasteur Hospital   (France)

^j Clinique Sainte Clotilde   (France)

^k CHRU ^*  (France)

^l LILLE UNIVERSITY HOSPITAL   (France)

^m Service de Cardiologie CH   (France)

ⁿ UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^o Service de Cardiologie CH   (France)

^p Service de Radiologie   (France)

^q HÔPITAL AMBROISE PARÉ   (France)

^r HÔPITAL FERNAND WIDAL   (France)

^s ACTION Study Group   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; PRASUGREL; PIPERAZINE DERIVATIVE; PURINERGIC P2Y RECEPTOR ANTAGONIST; THIOPHENE DERIVATIVE;

ACUTE CORONARY SYNDROME; AGED; ARTICLE; BLEEDING; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; CORONARY ARTERY RECANALIZATION; CORONARY STENTING; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY (TOPIC); OPEN STUDY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PATIENT MONITORING; PERCUTANEOUS CORONARY INTERVENTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); STENT THROMBOSIS; THROMBOCYTE FUNCTION; BLOOD CLOTTING PARAMETERS; CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG MONITORING; HEMORRHAGE; MULTICENTER STUDY; MYOCARDIAL ISCHEMIA; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; STENT; TREATMENT OUTCOME; VERY ELDERLY;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; HEMORRHAGE; HUMANS; MYOCARDIAL ISCHEMIA; PERCUTANEOUS CORONARY INTERVENTION; PIPERAZINES; PLATELET FUNCTION TESTS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; STENTS; THIOPHENES; TREATMENT OUTCOME;

EID: 84908334358     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2014.07.026     Document Type: Article

References (31)

1. K.P. Alexander, L.K. Newby, and C.P. Cannon Acute coronary care in the elderly, part I: non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology Circulation 115 19 2007 2549 2569
2. K.P. Alexander, L.K. Newby, and P.W. Armstrong Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology Circulation 115 19 2007 2570 2589
3. J. Silvain, G. Cayla, and J.S. Hulot High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study Eur Heart J 33 10 2012 1241 1249
4. D. Capodanno, and D.J. Angiolillo Antithrombotic therapy in the elderly J Am Coll Cardiol 56 21 2010 1683 1692
5. M.T. Roe, S.G. Goodman, and E.M. Ohman Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel Circulation 128 8 2013 823 833
6. Trial of invasive versus medical therapy in elderly patients with chronic symptomatic coronary-artery disease (TIME): a randomised trial Lancet 358 9286 2001 951 957
7. G. Montalescot, G. Sideris, and R. Cohen Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study Thromb Haemost 103 1 2010 213 223
8. S.D. Wiviott, E. Braunwald, and C.H. McCabe Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 20 2007 2001 2015
9. R.E. Wrishko, C.S. Ernest II, and D.S. Small Population pharmacokinetic analyses to evaluate the influence of intrinsic and extrinsic factors on exposure of prasugrel active metabolite in TRITON-TIMI 38 J Clin Pharmacol 49 8 2009 984 998
10. D. Erlinge, P.A. Gurbel, and S. James Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients J Am Coll Cardiol 62 7 2013 577 583
11. M.T. Roe, P.W. Armstrong, and K.A. Fox Prasugrel versus clopidogrel for acute coronary syndromes without revascularization N Engl J Med 367 14 2012 1297 1309
12. G. Montalescot, L. Bolognese, and D. Dudek Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes N Engl J Med 369 11 2013 999 1010
13. J.P. Collet, T. Cuisset, and G. Range Bedside monitoring to adjust antiplatelet therapy for coronary stenting N Engl J Med 367 22 2012 2100 2109
14. L. Wallentin, R.C. Becker, and A. Budaj Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 11 2009 1045 1057
15. S.R. Mehta, J.P. Bassand, and S. Chrolavicius Dose comparisons of clopidogrel and aspirin in acute coronary syndromes N Engl J Med 363 10 2010 930 942
16. G. Montalescot, U. Zeymer, and J. Silvain Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: the international randomised open-label ATOLL trial Lancet 378 9792 2011 693 703
17. G. Campo, L. Fileti, and N. de Cesare Long-term clinical outcome based on aspirin and clopidogrel responsiveness status after elective percutaneous coronary intervention: a 3 T/2R (tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel) trial substudy J Am Coll Cardiol 56 18 2010 1447 1455
18. P.A. Gurbel, D. Erlinge, and E.M. Ohman Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy JAMA 308 17 2012 1785 1794
19. M.J. Price, P.B. Berger, and P.S. Teirstein Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial JAMA 305 11 2011 1097 1105
20. G.W. Stone, B. Witzenbichler, and G. Weisz Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study Lancet 382 9892 2013 614 623
21. U.S. Tantry, L. Bonello, and D. Aradi Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding J Am Coll Cardiol 62 24 2013 2261 2273
22. G. Campo, G. Parrinello, and P. Ferraresi Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome J Am Coll Cardiol 57 25 2011 2474 2483
23. K. Thygesen, J.S. Alpert, and H.D. White Universal definition of myocardial infarction Circulation 116 22 2007 2634 2653
24. D.E. Cutlip, S. Windecker, and R. Mehran Clinical end points in coronary stent trials: a case for standardized definitions Circulation 115 17 2007 2344 2351
25. R.D. Lopes, K.P. Alexander, and S.V. Manoukian Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial J Am Coll Cardiol 53 12 2009 1021 1030
26. S. Savonitto, C. Cavallini, and A.S. Petronio Early aggressive versus initially conservative treatment in elderly patients with non-ST-segment elevation acute coronary syndrome: a randomized controlled trial JACC Cardiovasc Interv 5 9 2012 906 916
27. C. Konrat, I. Boutron, and L. Trinquart Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs PLoS One 7 3 2012 e33559
28. H.L. Dauerman, D.L. Bhatt, and D.D. Gretler Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients Am Heart J 159 4 2010 [508-17 e1]
29. G. Montalescot, E. Vicaut, and J.P. Collet Bedside monitoring of antiplatelet therapy for coronary stenting N Engl J Med 368 9 2013 871 872
30. N.J. Breet, J.W. van Werkum, and H.J. Bouman Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation JAMA 303 8 2010 754 762
31. Steering Committee of the Physicians' Health Study Research Group Final report on the aspirin component of the ongoing Physicians' Health Study N Engl J Med 321 3 1989 129 135