Impact of time to treatment intensification on glycemic goal attainment among patients with type 2 diabetes failing metformin monotherapy

Journal of Diabetes and its Complications

Volumn 28, Issue 6, 2014, Pages 831-835

  Rajpathak, Swapnil N ^a   Rajgopalan, Srini ^b   Engel, Samuel S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Med Data Analytics   (United States)

Author keywords

Diabetes; Failure; Glycemic; Goal; Intensification; Treatment

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; HEMOGLOBIN A1C; INSULIN; METFORMIN; ORAL ANTIDIABETIC AGENT; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADD ON THERAPY; ADULT; AGE DISTRIBUTION; ARTICLE; CARDIOVASCULAR DISEASE; CHARLSON COMORBIDITY INDEX; DIABETIC PATIENT; DRUG TREATMENT FAILURE; DRUG USE; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; GLYCEMIC CONTROL; GOAL ATTAINMENT; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PRESCRIPTION; RETROSPECTIVE STUDY; SEX DIFFERENCE; TIME TO TREATMENT; AGED; DIABETES MELLITUS, TYPE 2; DRUG COMBINATION; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; MOTIVATION; ORAL DRUG ADMINISTRATION; STATISTICS AND NUMERICAL DATA; TREATMENT FAILURE;

ADMINISTRATION, ORAL; AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; FEMALE; GOALS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; MIDDLE AGED; RETROSPECTIVE STUDIES; TIME-TO-TREATMENT; TREATMENT FAILURE;

EID: 84908311247     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2014.06.004     Document Type: Article

References (24)

1. D.R. Berlowitz, A.S. Ash, J. Glockman, R.H. Friedman, L.M. Pogach, and A.L. Nelson Developing a quality measure for clinical inertia in diabetes care Health Services Research 40 2005 1854 1861
2. J.B. Brown, C. Conner, and G.A. Nichols Secondary failure of metformin monotherapy in clinical practice Diabetes Care 33 2010 501 506
3. J.B. Brown, and G.A. Nichols Slow response to loss of glycemic control in type 2 diabetes mellitus American Journal of Managed Care 9 2003 213 217
4. J.B. Brown, G.A. Nichols, and A. Perry The burden of treatment failure in type 2 diabetes Diabetes Care 27 2004 1535 1540
5. S.S. Casagrande, J.E. Fradkin, S.H. Saydah, K.F. Rust, and C.C. Cowie The prevalence of meeting A1c, blood pressure, and LDL goals among people with diabetes, 1988-2010 Diabetes Care 36 2013 2271 2279
6. Centers for Disease Control and Prevention National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States Available at http://www.cdc.gov/diabetes/pubs/pdf/ndfs2011.pdf 2011 (Accessed April 22, 2013)
7. B.M. Cheung, K.L. Ong, S.S. Cherny, P.C. Sham, A.W. Tso, and K.S. Lam Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006 American Journal of Medicine 122 2009 443 453
8. S. Colagiuri, C.A. Cull, R.R. Holman, and for the UKPDS Group Are lower fasting plasma glucose levels at diagnosis of type 2 diabetes associated with improved outcomes? UK Prospective Diabetes Study 61 Diabetes Care 25 2002 1410 1417
9. M.N. Cook, C.J. Girman, P.P. Stein, and C.M. Alexander Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care Diabetic Medicine 24 2007 350 358
10. A.Z. Fu, Y. Qiu, M.J. Davies, L. Radican, and S.S. Engel Treatment intensification in patients with type 2 diabetes who failed metformin monotherapy Diabetes, Obesity & Metabolism 13 2012 765 769
11. A.J. Garber, M.J. Abrahamson, J.I. Barzilay, L. Blonde, Z.T. Bloomgarden, and M.A. Bush AACE comprehensive diabetes management algorithm 2013 Endocrine Practice 19 Suppl. 2 2013 S1 S48
12. R. Grant, A.S. Adams, C.M. Trinacty, F. Zhang, K. Kleimna, and S.B. Soumerai Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management Diabetes Care 30 2007 807 812
13. E.W. Gregg, Y.J. Cheng, S. Saydah, C. Cowie, S. Garfield, and L. Geiss Trends in death rates among US adults with and without diabetes between 1997 and 2006 Diabetes Care 35 2012 1252 1257
14. S.E. Inzucchi, R.M. Bergenstal, J.B. Buse, M. Diamant, E. Ferrannini, and M. Nauck Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care 3 2012 1364 1379
15. K. Johansen Efficacy of metformin in the treatment of NIDDM: meta-analysis Diabetes Care 22 1999 33 37
16. L.N. McEwan, C.M. Mangione, D. Bilik, U. Subramanian, S.L. Johnson, and B. Weitzfelder Predictors and impact of intensification of antihyperglycemic therapy in type 2 diabetes Diabetes Care 32 2009 971 976
17. G.A. Nichols, C.M. Alexander, C.J. Girman, S.J. Kamal-Bahl, and J.B. Brown Treatment escalation and rise in HbA1c following successful initial metformin therapy Diabetes Care 29 2006 504 509
18. L.S. Phillips, W.T. Branch, C.B. Cook, J.P. Doyle, I.M. El-Kebbi, and D.L. Gallina Clinical inertia Annals of Internal Medicine 135 2001 825 834
19. L. Phillips, D.C. Ziemer, J.P. Doyle, C.S. Barnes, P. Kolm, and W.T. Branch An endocrinologist-supported intervention aimed at providers improves diabetes management in a primary care site Diabetes Care 28 2005 2352 2360
20. UK Prospective Diabetes Study (UKPDS) Group Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33): UK Prospective Diabetes Study (UKPDS) Group Lancet 352 1998 837 853
21. N. Rodondi, T. Peng, A.J. Karter, D.C. Bauer, E. Vittinghoff, and S. Tang Treatment intensifications in response to poorly controlled hypertension, dyslipidemia, and diabetes mellitus Annals of Internal Medicine 144 2006 475 484
22. V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, and W.B. Borden Heart disease and stroke statistics - 2012 update: a report from the American Heart Association Circulation 125 2012 e2 e220
23. J.A. Schmittdiel, C.S. Uratsu, A.J. Karter, M. Heisler, U. Subramanian, and C.M. Mangione Why don't diabetes patients achieve recommended risk factor targets? Poor adherence versus lack of treatment intensification Journal of General Internal Medicine 23 2008 588 594
24. R.C. Turner, C.A. Cull, V. Frighi, and R.R. Holman Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group JAMA 281 1999 2005 2012