Risk of colectomy in patients with ulcerative colitis under thiopurine treatment

Journal of Crohn's and Colitis

Volumn 8, Issue 10, 2014, Pages 1287-1293

  Cañas Ventura, Alex ^a   Márquez, Lucia ^a   Ricart, Elena ^b,c   Domènech, Eugeni ^c,d   Gisbert, Javier P ^c,e   García Sanchez, Valle ^f   Marín Jiménez, Ignacio ^c,g   Rodriguez Moranta, Francisco ^h   Gomollón, Fernando ^c,i   Calvet, Xavier ^c,j,k,s   Merino, Olga ^l   Garcia Planella, Esther ^m   Vázquez Romero, Narcis ⁿ   Esteve, Maria ^c,o   Iborra, Marisa ^c,p   Gutiérrez, Ana ^q   Vera, Maribel ^r   Andreu, Montserrat ^a,t   Panes J ^b   Garcia V ^f   Penalva M ^h   Garcia Planella E ^m   Vera, I ^r   Nos, P ^p   Vazquez N ⁿ   Gento, E ^u   Fernandez Salazar L ^v   Barrio, J ^w   Martin M D ^x   Munoz F ^y   Ponferrada, A ^z   Hinojosa, J ^aa   Piqueras, M ^ab   Mendoza, J C ^ac   Cabriada, J L ^ad   Munoz C ^ae   Vilar, P ^af   Montoro, M A ^ag   Algaba, A ^ah   Botella, B ^ai   Saro, C ^aj   Barreiro, M ^ak   Aldeguer, X ^al   more..

^a HOSPITAL DEL MAR   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^e HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^f HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^g HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^h HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

ⁱ HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^j Centre de Salut Mental   (Spain)

^k UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^l HOSPITAL DE CRUCES   (Spain)

^m HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

ⁿ HOSPITAL GENERAL UNIVERSITARIO DE ELCHE   (Spain)

^o HOSPITAL MÚTUA DE TERRASSA   (Spain)

^p HOSPITAL UNIVERSITARIO LA FE   (Spain)

^q HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^r HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^s HOSPITAL DE SABADELL   (Spain)

^t Parc de Salut Mar   (Spain)

^u HOSPITAL UNIVERSITARIO DE BURGOS   (Spain)

^v HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^w HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^x HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^y HOSPITAL DE LEÓN   (Spain)

^z HOSPITAL UNIVERSITARIO INFANTA LEONOR   (Spain)

^aa HOSPITAL DE SAGUNTO   (Spain)

^ab Brain   (Spain)

^ac HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^ad HOSPITAL DE GALDAKAO   (Spain)

^ae HOSPITAL DE BASURTO   (Spain)

^af HOSPITAL SANT JOAN DE DÉU   (Spain)

^ag HOSPITAL SAN JORGE   (Spain)

^ah HOSPITAL UNIVERSITARIO DE FUENLABRADA   (Spain)

^ai HOSPITAL INFANTA CRISTINA   (Spain)

^aj HOSPITAL DE CABUEÑES   (Spain)

^ak University Hospital of Santiago de Compostela   (Spain)

^al HOSPITAL JOSEP TRUETA   (Spain)

more..

Author keywords

Colectomy; Inflammatory bowel diseases; Thiopurines; Ulcerative colitis

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; MERCAPTOPURINE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; IMMUNOSUPPRESSIVE AGENT; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ADULT; AGE; ARTICLE; CLINICAL PRACTICE; COHORT ANALYSIS; COLON PERFORATION; COLON RESECTION; DISEASE SEVERITY; DRUG WITHDRAWAL; EXTRAINTESTINAL MANIFESTATION; FAMILY HISTORY; FEMALE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL INTOLERANCE; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PREVALENCE; SMOKING; SPAIN; SURGICAL RISK; SURVIVAL; TIME TO TREATMENT; TOXIC MEGACOLON; ULCERATIVE COLITIS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; COLITIS, ULCERATIVE; KAPLAN MEIER METHOD; PROBABILITY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

6-MERCAPTOPURINE; ADULT; COLECTOMY; COLITIS, ULCERATIVE; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KAPLAN-MEIER ESTIMATE; MALE; PROBABILITY; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SPAIN; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84908238784     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2014.03.014     Document Type: Article

References (20)

1. Danese S., Fiocchi C. Ulcerative colitis. N Engl J Med 2011, 365:1713-1725.
2. Faubion W.A., Loftus E.V., Harmsen W.S., Zinsmeister A.R., Sandborn W.J. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology 2001, 121:255-260.
3. Dignass A., Lindsay J.O., Sturm A., Windsor A., Colombel J.F., Allez M., et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management. J Crohns Colitis 2012, 6:991-1030.
4. Gisbert J.P., Linares P.M., McNicholl A.G., Mate J., Gomollon F. Meta-analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis. Aliment Pharmacol Ther 2009, 30:126-137.
5. Khan K.J., Dubinsky M.C., Ford A.C., Ullman T.A., Talley N.J., Moayyedi P. Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol 2011, 106:630-642.
6. Langholz E., Munkholm P., Davidsen M., Binder V. Course of ulcerative colitis: analysis of changes in disease activity over years. Gastroenterology 1994, 107:3-11.
7. Kaplan G.G., Seow C.H., Ghosh S., Molodecky N., Rezaie A., Moran G.W., et al. Decreasing colectomy rates for ulcerative colitis: a population-based time trend study. Am J Gastroenterol 2012, 107:1879-1887.
8. Targownik L.E., Singh H., Nugent Z., Bernstein C.N. The epidemiology of colectomy in ulcerative colitis: results from a population-based cohort. Am J Gastroenterol 2012, 107:1228-1235.
9. Hoie O., Wolters F.L., Riis L., Bernklev T., Aamodt G., Clofent J., et al. Low colectomy rates in ulcerative colitis in an unselected European cohort followed for 10years. Gastroenterology 2007, 132:507-515.
10. Waljee A., Waljee J., Morris A.M., Higgins P.D. Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis. Gut 2006, 55:1575-1580.
11. Penna C., Dozois R., Tremaine W., Sandborn W., LaRusso N., Schleck C., et al. Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. Gut 1996, 38:234-239.
12. de Silva S., Ma C., Proulx M.C., Crespin M., Kaplan B.S., Hubbard J., et al. Postoperative complications and mortality following colectomy for ulcerative colitis. Clin Gastroenterol Hepatol 2011, 9:972-980.
13. Lennard-Jones J.E. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 1989, 170:2-6.
14. Satsangi J., Silverberg M.S., Vermeire S., Colombel J.F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006, 55:749-753.
15. Dignass A., Eliakim R., Magro F., Maaser C., Chowers Y., Geboes K., et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis. J Crohns Colitis 2012, 6:965-990.
16. Solberg I.C., Lygren I., Jahnsen J., Aadland E., Hoie O., Cvancarova M., et al. Clinical course during the first 10years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study). Scand J Gastroenterol 2009, 44:431-440.
17. Gower-Rousseau C., Dauchet L., Vernier-Massouille G., Tilloy E., Brazier F., Merle V., et al. The natural history of pediatric ulcerative colitis: a population-based cohort study. Am J Gastroenterol 2009, 104:2080-2088.
18. Williet N., Pillot C., Oussalah A., Billioud V., Chevaux J.B., Bresler L., et al. Incidence of and impact of medications on colectomy in newly diagnosed ulcerative colitis in the era of biologics. Inflamm Bowel Dis 2012, 18:1641-1646.
19. Garcia-Planella E., Manosa M., Van D.M., Gordillo J., Zabana Y., Cabre E., et al. Long-term outcome of ulcerative colitis in patients who achieve clinical remission with a first course of corticosteroids. Dig Liver Dis 2012, 44:206-210.
20. Panaccione R., Ghosh S., Middleton S.J., Velazquez J.R.M., Khalif I.L., Flint L., et al. Infliximab, azathioprine, or infliximab+azathioprine for treatment of moderate to severe ulcerative colitis: the UC SUCCESS trial 2011.