Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia

Mucosal Immunology

Volumn 7, Issue 6, 2014, Pages 1366-1374

  Ahn, D S ^a   Parker, D ^a   Planet, P J ^a   Nieto, P A ^b,c   Bueno, S M ^b,c   Prince, A ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b Pontificia Universidad Católica de Chile   (Chile)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CALCIUM ION; CALPAIN; CASPASE 3; CD4 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 16; STAPHYLOCOCCUS PROTEIN A; TUMOR NECROSIS FACTOR RECEPTOR 1; CASPASE; TNFRSF1A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; PATHOGENESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ACUTE DISEASE; ANIMAL; CALCIUM SIGNALING; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SECRETION (PROCESS); STAPHYLOCOCCAL PNEUMONIA;

ACUTE DISEASE; ANIMALS; CALCIUM SIGNALING; CALPAIN; CASPASES; HUMANS; INTERLEUKIN-16; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, KNOCKOUT; PNEUMONIA, STAPHYLOCOCCAL; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RESPIRATORY MUCOSA;

EID: 84908220382     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.24     Document Type: Article

References (46)

1. Klevens, R. M. et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298, 1763-1771 (2007).
2. American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilatorassociated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med 171, 388-416 (2005).
3. Morens, D. M., Taubenberger, J. K. & Fauci, A. S. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J. Infect. Dis. 198, 962-970 (2008).
4. Kollef, M. H. et al. Epidemiology and outcomes of health-care-associated pneumonia results from a large us database of culture-positive pneumonia. Chest 128, 3854-3862 (2005).
5. Inoshima, I. et al. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat. Med. 17, 1310-1314 (2011).
6. Diep, B. A. et al. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc. Natl. Acad. Sci. USA. 107, 5587-5592 (2010).
7. Martin, F. J. et al. Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A. J. Clin. Invest. 119, 1931-1939 (2009).
8. Kebaier,C. et al. Staphylococcus aureus a-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. J. Infect. Dis. 205, 807-817 (2012).
9. Gomez, M. I. et al. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat. Med. 10, 842-848 (2004).
10. Gomez, M. I. Staphylococcus aureus protein A activates TNFR1 signaling through conserved IgG binding domains. J. Biol. Chem. 281, 20190-20196 (2006).
11. Ichikawa, A. et al. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am. J. Respir. Crit. Care Med. 187, 65-77 (2013).
12. Martin, F. J., Parker, D., Harfenist, B. S., Soong,G. & Prince, A. Participation of CD11c() leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lung. Infect. Immun. 79, 1898-1904 (2011).
13. McLoughlin, R. M. et al. CD4 Tcells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc. Natl. Acad. Sci. USA. 103, 10408-10413 (2006).
14. Kö ckritz-Blickwede, von, M. et al. Immunological mechanisms underlying the genetic predisposition to severe staphylococcus aureus infection in the mouse model. Am. J. Pathol. 173, 1657-1668 (2008).
15. Wilson, G. J. et al. A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia. PLoS Pathog. 7, e1002271 (2011).
16. Jiang, D. et al. Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation. Am. J. Respir. Cell Mol. Biol. 46, 592-598 (2012).
17. Hamza, T., Barnett, J. B. & Li, B. Interleukin 12 a key immunoregulatory cytokine in infection applications. Int. J. Mol. Sci. 11, 789-806 (2010).
18. Cruikshank, W. W., Kornfeld, H. & Center, D. M. Interleukin-16. J. Leukoc. Biol. 67, 757-766 (2000).
19. Cruikshank, W. & Center, D. M. Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF). J. Immunol. 128, 2569-2574 (1982).
20. Cruikshank,W. & Little, F. lnterleukin-16: the ins and outs of regulating Tcell activation. Crit. Rev. Immunol. 28, 467-483 (2008).
21. Little, F. F., Lynch, E., Fine, G., Center, D. M. & Cruikshank, W. W. Tumor necrosis factor-a-induced synthesis of interleukin-16 in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 28, 354-362 (2003).
22. Zhang, Y. et al. Processing and activation of pro-interleukin-16 by caspase-3 J. Biol. Chem. 273, 1144-1149 (1998).
23. Aggarwal, B. B. Signalling pathways of the TNF superfamily: a doubleedged sword. Nat. Rev. Immunol. 3, 745-756 (2003).
24. Wang, P. et al. IL-16 Induces intestinal inflammation via PepT1 upregulation in a pufferfish model: new insights into the molecular mechanism of inflammatory bowel disease. J. Immunol. 191, 1413-1427 (2013).
25. Gomez, M. I., Seaghdha, M. O. & Prince, A. S. Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. EMBO J. 26, 701-709 (2007).
26. Lavrik, I. N. & Krammer, P. H. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ. 19, 36-41 (2011).
27. Vaisid, T., Barnoy, S. & Kosower, N. S. Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-beta-peptide and CD95 pathways. Int. J. Biochem. Cell Biol. 41, 2450-2458 (2009).
28. Chun, J. & Prince, A. Activation of Ca2-dependent signaling by TLR2. J. Immunol. 177, 1330-1337 (2006).
29. Takeuchi, O., Hoshino, K. & Akira, S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165, 5392-5396 (2000).
30. Chae, H. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol. Res. 42, 373-381 (2000).
31. Center, D. M. & Cruikshank, W. Modulation of lymphocyte migration by human lymphokines. I. Identification and characterization of chemoattractant activity for lymphocytes from mitogen-stimulated mononuclear cells. J. Immunol. 128, 2563-2568 (1982).
32. Lynch, E. A., Heijens, C. A. W.,Horst, N. F.,Center, D. M. & Cruikshank,W. W. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J. Immunol. 171, 4965-4968 (2003).
33. Glass,W. G., Sarisky, R. T. & Vecchio, A. M. D. Not-so-sweet sixteen: the role of il-16 in infectious and immune-mediated inflammatory diseases. J. Interferon Cytokine Res. 26, 511-520 (2006).
34. Keane, J. et al. Conservation of structure and function between human and murine IL-16. J. Immunol. 160, 5945-5954 (1998).
35. Wilson, K. C., Center, D. M. & Cruikshank,W. W. The effect of interleukin-16 and its precursor on T lymphocyte activation and growth. Growth Factors 22, 97-104 (2004).
36. Ren, F. et al. Pro-IL-16 regulation in activated murine CD4 lymphocytes. J. Immunol. 174, 2738-2745 (2005).
37. Parker, D. & Prince, A. Immunopathogenesis of Staphylococcus aureus pulmonary infection. Semin. Immunopathol. 34, 281-297 (2012).
38. Hogan, P. G., Lewis, R. S. & Rao, A. Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu. Rev. Immunol. 28, 491-533 (2010).
39. Cohen, T. S. & Prince, A. S. Bacterial pathogens activate a common inflammatory pathway through IFNl regulation of PDCD4. PLoS Pathog. 9, e1003682 (2013).
40. Cohen, T. S. & Prince, A. S. Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia. J. Clin. Invest. 123, 1630-1637 (2013).
41. Archer, N. K., Harro, J. M. & Shirtliff, M. E. Clearance of Staphylococcus aureus nasal carriage is t cell dependent and mediated through interleukin-17a expression and neutrophil influx. Infect. Immun. 81, 2070-2075 (2013).
42. Ahuja, N. et al. Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Am. J. Physiol. Renal Physiol. 303, F864-F872 (2012).
43. Neumann, B. et al. Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Int. Immunol. 11, 217-227 (1999).
44. Diep, B. A. et al. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet 367, 731-739 (2006).
45. Meagher, C. et al. Neutralization of interleukin-16 protects nonobese diabetic mice from autoimmune type 1 diabetes by a CCL4-dependent mechanism. Diabetes 59, 2862-2871 (2010).
46. Parker, D. et al. Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract. MBio. 2, e00016-11 (2011).