Adjuvant single-fraction radiotherapy is safe and effective for intractable keloids

Journal of Radiation Research

Volumn 55, Issue 5, 2014, Pages 912-916

  Song, Changhoon ^a   Wu, Hong Gyun ^a,b   Chang, Hak ^a   Kim, Il Han ^a,b   Ha, Sung W ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

electron beam; keloid; radiation; single fraction

Indexed keywords

ELECTRON BEAMS; ELECTRON IRRADIATION; RADIOTHERAPY; SURGERY;

ADVERSE EFFECT; ELECTRON BEAM RADIOTHERAPY; ELECTRON-BEAM; FOLLOW UP; HIGH DOSE; HIGH DOSE RADIOTHERAPIES; KELOID; SINGLE FRACTIONS; SURGICAL EXCISION; UP PERIOD;

COST EFFECTIVENESS;

ADJUVANT THERAPY; ADULT; ADVERSE EFFECTS; CHRONIC DISEASE; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; FEMALE; HUMAN; KELOID; MALE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PROCEDURES; RADIATION DOSE FRACTIONATION; RADIODERMATITIS; TREATMENT OUTCOME;

ADULT; CHRONIC DISEASE; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; HUMANS; KELOID; MALE; MIDDLE AGED; RADIODERMATITIS; RADIOTHERAPY, ADJUVANT; RADIOTHERAPY, CONFORMAL; TREATMENT OUTCOME;

EID: 84908202560     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1093/jrr/rru025     Document Type: Article

References (16)

1. Cohen IK, Keiser HR, Sjoerdsma A. Collagen synthesis in human keloid and hypertrophic scar. Surg Forum 1971;22: 488-9.
2. Berman B, Bieley HC. Adjunct therapies to surgical management of keloids. Dermatol Surg 1996;22:126-30.
3. Guix B, Henriquez I, Andres A et al. Treatment of keloids by high-dose-rate brachytherapy: a seven-year study. Int J Radiat Oncol Biol Phys 2001;50:167-72.
4. Borok TL, Bray M, Sinclair I et al. Role of ionizing irradiation for 393 keloids. Int J Radiat Oncol Biol Phys 1988;15:865-70.
5. Kovalic JJ, Perez CA. Radiation therapy following keloidectomy: a 20-year experience. Int J Radiat Oncol Biol Phys 1989;17:77-80.
6. Escarmant P,Zimmermann S,Amar A,et al. The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision. Int J Radiat Oncol Biol Phys 1993;26:245-51.
7. Ogawa R, Miyashita T, Hyakusoku H et al. Postoperative radiation protocol for keloids and hypertrophic scars: statistical analysis of 370 sites followed for over 18 months. Ann Plast Surg 2007;59:688 -91.
8. Mustoe TA, Cooter RD, Gold MH et al. International clinical recommendations on scar management. Plast Reconstr Surg 2002;110:560-71.
9. Wagner W, Alfrink M, Micke O et al. Results of prophylactic irradiation in patients with resected keloids-A retrospective analysis. Acta Oncol 2000;39:217-20.
10. Lo TC, Seckel BR, Salzman FA et al. Single-dose electron beam irradiation in treatment and prevention of keloids and hypertrophic scars. Radiother Oncol 1990;19:267-72.
11. Sclafani AP, Gordon L, Chadha M et al. Prevention of earlobe kelo id recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg 1996;22:569-74.
12. Ragoowansi R, Cornes PG, Moss AL et al. Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy. Plast Reconstr Surg 2003;111: 1853-9.
13. Botwood N, Lewanski C, Lowdell C. The risks of treating keloids with radiotherapy. Br J Radiol 1999;72:1222-4.
14. Edsmyr F, Larsson LG, Onyango J et al. Radiation therapy in the treatment of keloids in East Africa. Acta Radiol Ther Phys Biol 1974;13:102-6.
15. Kal HB, Veen RE. Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Dose-effect relationship. Strahlenther Onkol 2005;181:717-23.
16. Sakamoto T, Oya N, Shibuya K et al. Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol 2009;91:271-6.