Genome-wide expression profiling of B lymphocytes reveals IL4R increase in allergic asthma

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 4, 2014, Pages 972-975

  Pascual, Marien ^a   Roa, Sergio ^a   García Sánchez, Asunción ^b,c   Sanz, Catalina ^b,c   Hernandez Hernandez, Laura ^c   Greally, John M ^d   Lorente, Félix ^b,c,e   Dávila, Ignacio ^b,c,e   Isidoro García, María ^b,c,e  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE SALAMANCA IBSAL   (Spain)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; CD19 ANTIBODY; CD27 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; METHACHOLINE; OMALIZUMAB; RNA; BIOLOGICAL MARKER; CD19 ANTIGEN; HOUSE DUST ALLERGEN; IL4R PROTEIN, HUMAN; INTERLEUKIN 4 RECEPTOR ALPHA;

ALLERGIC ASTHMA; ALLERGIC DISEASE; ALLERGIC REACTION; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOPHAGOIDES; DNA METHYLATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LETTER; LYMPHOCYTE; LYMPHOID TISSUE; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRICK TEST; PSEUDOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SEASONAL VARIATION; UPREGULATION; ANIMAL; ASTHMA; CELL CULTURE; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; PYROGLYPHIDAE;

ANIMALS; ANTIGENS, CD19; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERSENSITIVITY; INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT; PYROGLYPHIDAE; UP-REGULATION;

EID: 84908145762     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.05.015     Document Type: Article

References (10)

1. M. Isidoro-Garcia, I. Davila, E. Moreno, E. Laffond, F. Lorente, and R. Gonzalez-Sarmiento IL4RA gene polymorphism (Q576R) is associated with higher total IgE levels in Spanish patients with family history of atopy [in Spanish] Med Clin (Barc) 124 2005 211 212
2. M. Isidoro-Garcia, I. Davila, E. Laffond, E. Moreno, F. Lorente, and R. Gonzalez-Sarmiento Interleukin-4 (IL4) and interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study Clin Mol Allergy 3 2005 15
3. C. Ober, and T.C. Yao The genetics of asthma and allergic disease: a 21st century perspective Immunol Rev 242 2011 10 30
4. M. Pascual, M. Suzuki, M. Isidoro-Garcia, J. Padron, T. Turner, and F. Lorente Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma Epigenetics 6 2011 1131 1137
5. M. Pascual, I. Davila, M. Isidoro-Garcia, and F. Lorente Epigenetic aspects of the allergic diseases Front Biosci (Schol Ed) 2 2010 815 824
6. H.H. Jabara, S.M. Fu, R.S. Geha, and D. Vercelli CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells J Exp Med 172 1990 1861 1864
7. M.A. Chan, N.M. Gigliotti, J. Meng, and L.J. Rosenwasser Asthma-related SNP in FCER2 is associated with increased expression of IL-4R on human B cells Int J Immunogenet 38 2011 533 538
8. M.J. Loza, and B.L. Chang Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis J Allergy Clin Immunol 120 2007 578 585
9. A.L. Andrews, J.W. Holloway, S.T. Holgate, and D.E. Davies IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets J Immunol 176 2006 7456 7461
10. M.A. Chan, N.M. Gigliotti, A.L. Dotson, and L.J. Rosenwasser Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells Clin Transl Allergy 3 2013 29