Recurrent Postmenopausal Bleeding: A Prospective Cohort Study

Journal of Minimally Invasive Gynecology

Volumn 21, Issue 5, 2014, Pages 799-803

  Smith, Paul P ^a   O'Connor, Siobhan ^a   Gupta, Janesh ^a   Clark, T Justin ^a  

^a BIRMINGHAM WOMEN S HOSPITAL   (United Kingdom)

Author keywords

Endometrial cancer; Hysteroscopy; Polyps; Postmenopausal bleeding

Indexed keywords

ADULT; ARTICLE; CANCER RISK; COHORT ANALYSIS; ECHOGRAPHY; ENDOMETRIAL THICKNESS; ENDOMETRIUM BIOPSY; ENDOMETRIUM CANCER; ENDOMETRIUM HYPERPLASIA; ENDOMETRIUM POLYP; FEMALE; HUMAN; HYSTEROSCOPY; MAJOR CLINICAL STUDY; PELVIC EXAMINATION; POSTMENOPAUSE BLEEDING; PREVALENCE; PROSPECTIVE STUDY; RECURRENT DISEASE; BIOPSY; COMPLICATION; EARLY DIAGNOSIS; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; MIDDLE AGED; OUTPATIENT; PATHOLOGY; POLYP; POSTMENOPAUSE; PRECANCER; TEACHING HOSPITAL; URBAN POPULATION; UTERINE HEMORRHAGE; UTERINE NEOPLASMS;

BIOPSY; COHORT STUDIES; EARLY DETECTION OF CANCER; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HOSPITALS, TEACHING; HUMANS; HYSTEROSCOPY; MIDDLE AGED; OUTPATIENTS; POLYPS; POSTMENOPAUSE; PRECANCEROUS CONDITIONS; PREVALENCE; PROSPECTIVE STUDIES; URBAN POPULATION; UTERINE HEMORRHAGE; UTERINE NEOPLASMS;

EID: 84908136245     PISSN: 15534650     EISSN: 15534669     Source Type: Journal    
DOI: 10.1016/j.jmig.2014.03.007     Document Type: Article

References (27)

1. Astrup K., Olivarius N.F. Frequency of spontaneously occurring postmenopausal bleeding in the general population. Acta Obstet Gynecol Scand 2004, 83:203-207.
2. Bachmann L.M., ter Riet G., Clark T.J., Gupta J.K., Khan K.S. Probability analysis for diagnosis of endometrial hyperplasia and cancer in postmenopausal bleeding: an approach for a rational diagnostic workup. Acta Obstet Gynecol Scand 2003, 82:564-569.
3. NVOG Guideline: Abnormal Vaginal Bleeding During the Postmenopause 1997, Dutch Society of Obstetrics and Gynaecology (NVOG), NVOG, Utrecht, the Netherlands.
4. Scottish Intercollegiate Guidelines Network (SIGN). Investigation of Postmenopausal Bleeding. 1st ed [Internet]. SIGN, Royal College of Physicians; 2002. Available at: . http://www.sign.ac.uk.
5. Gupta J.K., Chien P.F.W., Voit D., Clark T.J., Khan K.S. Ultrasonographic endometrial thickness for diagnosing endometrial pathology in women with postmenopausal bleeding: a meta-analysis. Acta Obstet Gynecol Scand 2002, 81:799-816.
6. Smith-Bindman R., Kerlikowske K., Feldstein V.A., et al. Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 1998, 280:1510-1517.
7. Tabor A., Watt H.C., Wald N.J. Endometrial thickness as a test for endometrial cancer in women with postmenopausal vaginal bleeding. Obstet Gynecol 2002, 99:663-670.
8. Spencer C.P., Whitehead M.I. Endometrial assessment re-visited. Br JObstet Gynaecol 1999, 106:623-632.
9. Gull B., Karlsson B., Milsom I., Granberg S. Can ultrasound replace dilation and curettage? a longitudinal evaluation of postmenopausal bleeding and transvaginal sonographic measurement of the endometrium as predictors of endometrial cancer. Am J Obstet Gynecol 2003, 188:401-408.
10. Timmermans A., van Doorn L.C., Opmeer B.C., et al. Follow-up of women after a first episode of postmenopausal bleeding and endometrial thickness greater than 4 millimeters. Obstet Gynecol 2008, 111:137-143.
11. Feldman S., Shapter A., Welch W.R., Berkowitz R.S. Two-year follow-up of 263 patients with post/perimenopausal vaginal bleeding and negative initial biopsy. Gynecol Oncol 1994, 55:56-59.
12. Gimpelson R.J., Rappold H.O. A comparative study between panoramic hysteroscopy with directed biopsies and dilatation and curettage: a review of 276 cases. Am J Obstet Gynecol 1988, 158(3 Pt 1):489-492.
13. Lacey J.V., Ioffe O.B., Ronnett B.M., et al. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan. Br J Cancer 2008, 98:45-53.
14. Clark T.J., Neelakantan D., Gupta J.K. The management of endometrial hyperplasia: an evaluation of current practice. Eur J Obstet Gynecol Reprod Biol 2006, 125:259-264.
15. Gallos I.D., Krishan P., Shehmar M., Ganesan R., Gupta J.K. Relapse of endometrial hyperplasia after conservative treatment: a cohort study with long-term follow-up. Hum Reprod Oxf Engl 2013, 28:1231-1236.
16. Indraccolo U., Di Iorio R., Matteo M., Corona G., Greco P., Indraccolo S.R. The pathogenesis of endometrial polyps: a systematic semi-quantitative review. Eur J Gynaecol Oncol 2013, 34:5-22.
17. Svirsky R., Smorgick N., Rozowski U., et al. Can we rely on blind endometrial biopsy for detection of focal intrauterine pathology?. Am JObstet Gynecol 2008, 199:115.e1-115.e3.
18. Van Dongen H., de Kroon C.D., Jacobi C.E., Trimbos J.B., Jansen F.W. Diagnostic hysteroscopy in abnormal uterine bleeding: a systematic review and meta-analysis. BJOG 2007, 114:664-675.
19. Clark T.J., Barton P.M., Coomarasamy A., Gupta J.K., Khan K.S. Investigating postmenopausal bleeding for endometrial cancer: cost-effectiveness of initial diagnostic strategies. BJOG 2006, 113:502-510.
20. Bakour S.H., Khan K.S., Gupta J.K. The risk of premalignant and malignant pathology in endometrial polyps. Acta Obstet Gynecol Scand 2000, 79:317-320.
21. Lieng M., Istre O., Qvigstad E. Treatment of endometrial polyps: a systematic review. Acta Obstet Gynecol Scand 2010, 89:992-1002.
22. Nathani F., Clark T.J. Uterine polypectomy in the management of abnormal uterine bleeding: a systematic review. J Minim Invasive Gynecol 2006, 13:260-268.
23. De Kroon C.D., de Bock G.H., Dieben S.W.M., Jansen F.W. Saline contrast hysterosonography in abnormal uterine bleeding: a systematic review and meta-analysis. BJOG 2003, 110:938-947.
24. Timmermans A., Opmeer B.C., Veersema S., Mol B.W.J. Patients' preferences in the evaluation of postmenopausal bleeding. BJOG 2007, 114:1146-1149.
25. Fung Kee Fung M., Burnett M., Faught W. Does persistent postmenopausal bleeding justify hysterectomy?. Eur J Gynaecol Oncol 1997, 18:26-28.
26. Van Doorn H.C., Timmermans A., Opmeer B.C., et al. What is the recurrence rate of postmenopausal bleeding in women who have a thin endometrium during a first episode of postmenopausal bleeding?. Acta Obstet Gynecol Scand 2008, 87:89-93.
27. Ronghe R., Gaudoin M. Women with recurrent postmenopausal bleeding should be re-investigated but are not more likely to have endometrial cancer. Menopause Int 2010, 16:9-11.