Electroanatomic mapping and late gadolinium enhancement MRI in a genetic model of arrhythmogenic atrial cardiomyopathy

Journal of Cardiovascular Electrophysiology

Volumn 25, Issue 9, 2014, Pages 964-970

  Disertori, Marcello ^a,b   Masè, Michela ^c   Marini, Massimiliano ^a   Mazzola, Silvia ^a   Cristoforetti, Alessandro ^c   Del Greco, Maurizio ^a   Kottkamp, Hans ^d   Arbustini, Eloisa ^e   Ravelli, Flavia ^c  

^a SANTA CHIARA HOSPITAL   (Italy)

^b FONDAZIONE BRUNO KESSLER   (Italy)

^c UNIVERSITY OF TRENTO   (Italy)

^d Hirslanden Hospital   (Switzerland)

^e FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Atrial arrhythmias; Atrial cardiomyopathy; Atrial fibrosis; Electroanatomic mapping; Late gadolinium enhancement magnetic resonance imaging; NPPA gene

Indexed keywords

ANTIARRHYTHMIC AGENT; BIOLOGICAL MARKER; GADOLINIUM; NATRIURETIC PEPTIDE PRECURSOR A; UNCLASSIFIED DRUG; CONTRAST MEDIUM; GADOLINIUM PENTETATE;

ADULT; ARRHYTHMOGENESIS; ARTICLE; CARDIAC IMAGING; CARDIAC MAPPING SYSTEM; CARDIOMYOPATHY; CATHETER ABLATION; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; CONTRAST ENHANCEMENT; DISEASE ASSOCIATION; DRUG TREATMENT FAILURE; ELECTRIC POTENTIAL; FEMALE; GENE MUTATION; GENETIC MODEL; HEART ATRIUM ARRHYTHMIA; HEART ATRIUM CONDUCTION; HEART ATRIUM ENLARGEMENT; HEART ATRIUM FIBRILLATION; HEART MUSCLE FIBROSIS; HUMAN; MALE; NERVE BLOCK; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; SCAR FORMATION; SINUS ARREST; SINUS NODE DISEASE; SUPRAVENTRICULAR TACHYCARDIA; TREATMENT FAILURE; BIOLOGICAL MODEL; DIAGNOSTIC USE; FIBROSIS; GENETICS; HEART ARRHYTHMIA; HEART ATRIUM; HEART FUNCTION TEST; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; SCAR;

ADULT; ARRHYTHMIAS, CARDIAC; CICATRIX; CONTRAST MEDIA; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; FIBROSIS; GADOLINIUM DTPA; HEART ATRIA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MODELS, GENETIC;

EID: 84908135590     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12440     Document Type: Article

References (21)

1. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W: KCNQ1 gainof- function mutation in familial atrial fibrillation. Science 2003;299: 251-254.
2. Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, Horton SC, Rodeheffer RJ, Anderson JL: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA 2005;293:4447-4454
3. Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett JC Jr, Olson TM. Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. N Engl J Med 2008;359:158-165.
4. Mahida S, Lubitz SA, Rienstra M, Milan DJ, Ellinor PT: Monogenic atrial fibrillation as pathophysiological paradigms. Cardiovasc Res 2011;89:692-700.
5. Kodama T, Serio A, Disertori M, Bronzetti G, Diegoli M, Narula N, Grasso M, Mazzola S, Arbustini E: Autosomal recessive pediatric sick sinus syndrome associated with novel compound mutations in SCN5A. Int J Cardiol 2013;167:3078-3080.
6. Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K, Itoh H, Kimura T, Kita T, Horie M: A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation. J Am Coll Cardiol 2008;52:1326-1334.
7. Varma N, Helms R, Benson DW, Sanagala T: Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. Circ Arrhythm Electrophysiol 2011;4:e52-e58.
8. Disertori M, Quintarelli S, Grasso M, Pilotto A, Narula N, Favalli V, CancliniC,DiegoliM,Mazzola S, Marini M, DelGreco M, Bonmassari R, Masè M, Ravelli F, Specchia C, Arbustini E: Autosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of Natriuretic Peptide Precursor A. Circ Cardiovasc Genet 2013;6:27-36.
9. Akoum N, McGann C, Vergara G, Badger T, Ranjan R, Mahnkopf C, Kholmovski E, Macleod R, Marrouche N: Atrial fibrosis quantified using late gadolinium enhancement MRI is associated with sinus node dysfunction requiring pacemaker implant. J Cardiovasc Electrophysiol 2012;23:44-50.
10. Oakes RS, Badger TJ, Kholmovski EG, Akoum N, Burgon NS, Fish EN, Blauer JJ, Rao SN, DiBella EV, Segerson NM, Daccarett M, Windfelder J, McGann CJ, Parker D, MacLeod RS, Marrouche NF: Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Circulation 2009;119:1758-1767.
11. Cristoforetti A, Faes L, Ravelli F, Centonze M, Del Greco M, Antolini R, Nollo G: Isolation of the left atrial surface from cardiac multidetector CT images based on marker controlled watershed segmentation. Med Eng Phys 2008;30:48-58.
12. Cristoforetti A, Masè M, Faes L, Centonze M, Del Greco M, Antolini R, Nollo G, Ravelli F: A stochastic approach for automatic registration and fusion of left atrial electroanatomic maps with 3D CT anatomical images. Phys Med Biol 2007;52:6323-6337.
13. Ravelli F, Masè M, Del Greco M, Marini M, Disertori M: Acute atrial dilatation slows conduction and increases AF vulnerability in the human atrium. J Cardiovasc Electrophysiol 2011;22:394-401.
14. Kottkamp H: Fibrotic atrial cardiomyopathy: A specific disease/ syndrome supplying substrate for atrial fibrillation, atrial tachycardia, sinus node disease, AV node disease, and thromboembolic complication. J Cardiovasc Electrophysiol 2012;797-799.
15. Kottkamp H: Human atrial fibrillation substrate: Towards a specific fibrotic atrial cardiomyopathy. Eur Heart J 2013;34:2731-2738.
16. Verma A,Wazni OM, Marrouche NF, Martin DO, Kilicaslan F, Minor S, Schweikert RA, SalibaW, Cummings J, Burkhardt JD, Bhargava M, BeldenWA, Abdul-Karim A, Natale A: Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: An independent predictor of procedural failure. J Am Coll Cardiol 2005;45:285-292.
17. Mahnkopf C, Badger TJ, Burgon NS, Daccarett M, Haslam TS, Badger CT, McGann CJ, Akoum N, Kholmovski E, Macleod RS, Marrouche NF: Evaluation of left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: Implications for disease progression and response to catheter ablation. Heart Rhythm 2010;7:1475-1481.
18. Daccarett M, Badger TJ, Akoum N, Burgon NS, Mahnkopf C, Vergara G, Kholmovski E, McGann CJ, Parker D, Brachmann J, Macleod RS, Marrouche NF: Association of left atrial fibrosis detected by delayedenhancement magnetic resonance imaging and the risk of stroke in patients with atrial fibrillation. J Am Coll Cardiol 2011;57:831-838.
19. Burstein B, Nattel S: Atrial fibrosis: Mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 2008;51:802-809.
20. Savelieva I, Kakouros N,Kourliouros A,CammAJ:Upstream therapies for management of atrial fibrillation: Review of clinical evidence and implications for European Society of Cardiology guidelines. Part I: Primary prevention. Europace 2011;13:308-328.
21. DisertoriM, LatiniR,Barlera S, FranzosiMG, Staszewsky L, Maggioni AP, Lucci D, Di Pasquale G, Tognoni G: Valsartan for prevention of recurrent atrial fibrillation. N Engl J Med 2009;360:1606-1617.