Hantavirus infection with severe proteinuria and podocyte foot-process effacement

American Journal of Kidney Diseases

Volumn 64, Issue 3, 2014, Pages 452-456

  Boehlke, Christopher ^a   Hartleben, Björn ^a,b   Huber, Tobias B ^a,c   Hopfer, Helmut ^d   Walz, Gerd ^a   Neumann Haefelin, Elke ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

acute kidney failure; Hantavirus infection; podocyte foot process effacement; proteinuria

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATININE; DIPYRONE; LACTATE DEHYDROGENASE; PODOCIN; PROTEIN ZO1;

ACUTE KIDNEY FAILURE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; CREATININE BLOOD LEVEL; DISEASE COURSE; DISEASE SEVERITY; ELECTRON MICROSCOPY; GLOMERULAR FILTRATION BARRIER; GLOMERULUS FILTRATION RATE; HANTAVIRUS INFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY DISEASE; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MICROSCOPY; PODOCYTE; PODOCYTE FOOT PROCESS EFFACEMENT; PROTEIN LOCALIZATION; PROTEINURIA; TRANSMISSION ELECTRON MICROSCOPY; UREA NITROGEN BLOOD LEVEL; URINE VOLUME;

ACUTE KIDNEY FAILURE; HANTAVIRUS INFECTION; PODOCYTE FOOT-PROCESS EFFACEMENT; PROTEINURIA;

ADULT; HANTAVIRUS INFECTIONS; HUMANS; MALE; PODOCYTES; PROTEINURIA; SEVERITY OF ILLNESS INDEX;

EID: 84908133858     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2014.04.030     Document Type: Article

References (32)

1. O. Vapalahti, J. Mustonen, Å. Lundkvist, H. Henttonen, A. Plyusnin, and A. Vaheri Hantavirus infections in Europe Lancet Infect Dis 3 2003 653 661
2. E. Krautkrämer, M. Zeier, and A. Plyusnin Hantavirus infection: an emerging infectious disease causing acute renal failure Kidney Int 83 1 2013 23 27
3. J. Mustonen, S. Mäkelä, and T. Outinen et al. The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions Antiviral Res 100 3 2013 589 604
4. A. Vaheri, H. Henttonen, and L. Voutilainen Hantavirus infections in Europe and their impact on public health Rev Med Virol 23 1 2013 35 49
5. Y. Balabanova, A. Gilsdorf, and S. Buda et al. Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011 PLoS One 6 10 2011 e25691
6. P. Makary, M. Kanerva, J. Ollgren, M.J. Virtanen, O. Vapalahti, and O. Lyytikäinen Disease burden of Puumala virus infections, 1995-2008 Epidemiol Infect 138 10 2010 1484 1492
7. C. Reusken, and P. Heyman Factors driving Hantavirus emergence in Europe Curr Opin Virol 3 1 2013 92 99
8. M. Bharadwaj, R. Nofchissey, D. Goade, F. Koster, and B. Hjelle Humoral immune responses in the Hantavirus cardiopulmonary syndrome J Infect Dis 182 1 2000 43 48
9. J. Mustonen, H. Helin, and K. Pietilä et al. Renal biopsy findings and clinicopathologic correlations in nephropathia epidemica Clin Nephrol 41 3 1994 121 126
10. A.G. Lordemann, B. Hjelle, and D. Theegarten et al. Young man with kidney failure and hemorrhagic interstitial nephritis Am J Kidney Dis 54 6 2009 1162 1166
11. J. Mustonen, S. Mäkelä, and H. Helin et al. Mesangiocapillary glomerulonephritis caused by Puumala Hantavirus infection Nephron 89 4 2001 402 407
12. S. Kim, S.H. Sung, and H.R. An et al. A case report of crescentic glomerulonephritis associated with Hantaan virus infection Nephrol Dial Transplant 25 8 2010 2790 2792
13. Y. Collan, M.J. Mihatsch, J. Lähdevirta, E.J. Jokinen, T. Romppanen, and E. Jantunen Nephropathia epidemica: mild variant of hemorrhagic fever with renal syndrome Kidney Int Suppl 35 1991 S62 S71
14. Y. Collan, J. Lähdevirta, and E.J. Jokinen Electron microscopy of nephropathia epidemica. glomerular changes Virchows Arch A Pathol Anat Histol 377 2 1978 129 144
15. E. Krautkrämer, D.H. Kruger, and M. Zeier Recent outbreaks of Hantavirus disease in Germany and in the United States Kidney Int 82 12 2012 1243 1245
16. D.H. Krüger, R.G. Ulrich, and J. Hofmann Hantaviruses as zoonotic pathogens in Germany Dtsch Arztebl Int 110 27-28 2013 461 467
17. U. Helmchen, U. Kneissler, and J. Velden Hantavirusinduzierte Nephropathia epidemica Der Nephrol 5 6 2010 501 507
18. J. Mustonen, M. Brummer-Korvenkontio, K. Hedman, A. Pasternack, K. Pietilä, and A. Vaheri Nephropathia epidemica in Finland: a retrospective study of 126 cases Scand J Infect Dis 26 1 1994 7 13
19. I. Ala-Houhala, M. Koskinen, and T. Ahola et al. Increased glomerular permeability in patients with nephropathia epidemica caused by Puumala Hantavirus Nephrol Dial Transplant 17 2 2002 246 252
20. M.H. Miettinen, S.M. Mäkelä, and I.O. Ala-Houhala et al. Ten-year prognosis of Puumala Hantavirus-induced acute interstitial nephritis Kidney Int 69 11 2006 2043 2048
21. D. Ferluga, and A. Vizjak Hantavirus nephropathy J Am Soc Nephrol 19 9 2008 1653 1658
22. M.T. Nguyen, S.E. Maynard, and P.L. Kimmel Misapplications of commonly used kidney equations: renal physiology in practice Clin J Am Soc Nephrol 4 3 2009 528 534
23. B. Haraldsson, J. Nyström, and W.M. Deen Properties of the glomerular barrier and mechanisms of proteinuria Physiol Rev 88 2 2008 451 487
24. F. Grahammer, C. Schell, and T.B. Huber The podocyte slit diaphragm - from a thin grey line to a complex signalling hub Nat Rev Nephrol 9 10 2013 587 598
25. T. Matthaeus, J. Fries, M. Weber, and E. Schulze-Lohoff [Glomerular-type proteinuria in Hantavirus nephritis] Med Klin (Munich) 99 5 2004 223 227
26. E. Krautkrämer, S. Grouls, N. Stein, J. Reiser, and M. Zeier Pathogenic old world Hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts J Virol 85 19 2011 9811 9823
27. E.T. McCarthy, R. Sharma, and M. Sharma et al. TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide J Am Soc Nephrol 9 3 1998 433 438
28. M. Temonen, J. Mustonen, H. Helin, A. Pasternack, A. Vaheri, and H. Holthöfer Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: an immunohistochemical study Clin Immunol Immunopathol 78 1 1996 47 55
29. M. Linderholm, C. Ahlm, B. Settergren, A. Waage, and A. Tärnvik Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome J Infect Dis 173 1 1996 38 43
30. S. Mäkelä, J. Mustonen, and I. Ala-Houhala et al. Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala Hantavirus-induced nephritis Am J Kidney Dis 43 5 2004 809 816
31. T. Sironen, J. Klingström, A. Vaheri, L.C. Andersson, A. Lundkvist, and A. Plyusnin Pathology of Puumala Hantavirus infection in macaques PLoS One 3 8 2008 e3035
32. M.N. Pensiero, J.B. Sharefkin, C.W. Dieffenbach, and J. Hay Hantaan virus infection of human endothelial cells J Virol 66 10 1992 5929 5936