Iron uptake and ferrokinetics in healthy male subjects of an iron-based oral phosphate binder (SBR759) labeled with the stable isotope 58Fe

Metallomics

Volumn 6, Issue 11, 2014, Pages 2062-2071

  Gschwind, Hans Peter ^a   Schmid, Dietmar G ^a   Von Blanckenburg, Friedhelm ^b,d   Oelze, Marcus ^b,d   Van Zuilen, Kirsten ^b,e   Slade, Alan J ^c   Stitah, Sylvie ^a   Kaufmann, Daniel ^a   Swart, Piet ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d GFZ GERMAN RESEARCH CENTRE FOR GEOSCIENCES   (Germany)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROLLED DRUG DELIVERY; ELECTROMAGNETIC INDUCTION; HEMATITE; MASS SPECTROMETRY; TARGETED DRUG DELIVERY;

CARBONATE COMPLEXES; CHRONIC KIDNEY DISEASE; CONCOMITANT REDUCTION; GASTROINTESTINAL TRACT; INDUCTIVELY COUPLED MASS SPECTROMETRIES; INORGANIC PHOSPHATES; PHOSPHATE BINDERS; PHOSPHATE CONCENTRATION;

ISOTOPES;

FERRITIN; HEMOGLOBIN; IRON; IRON 54; IRON 57; PHOSPHATE; PHOSPHATE BINDING AGENT; PHOSPHORUS; SBR 759 FE 58; STABLE ISOTOPE; TRANSFERRIN; UNCLASSIFIED DRUG; DRUG COMBINATION; FERRIC ION; SBR 759; STARCH;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CHRONIC KIDNEY DISEASE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIARRHEA; DRUG ABSORPTION; DRUG SAFETY; DRUG TOLERABILITY; ERYTHROCYTE; ERYTHROCYTE LIFESPAN; FERROKINETIC; FLATULENCE; HEADACHE; HEMATOCRIT; HUMAN; IRON ABSORPTION; IRON BLOOD LEVEL; IRON KINETICS; IRON OVERLOAD; IRON STORAGE; IRON TRANSPORT; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; MEAL; MULTI COLLECTOR INDUCTIVELY COUPLED MASS SPECTROMETRY; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PHOSPHATE BLOOD LEVEL; RADIOACTIVITY; SINGLE DRUG DOSE; ADOLESCENT; BLOOD; DRUG COMBINATION; KINETICS; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; DRUG COMBINATIONS; FERRIC COMPOUNDS; FERRITINS; HEMATOCRIT; HEMOGLOBINS; HUMANS; IRON ISOTOPES; KINETICS; MALE; MIDDLE AGED; STARCH; TRANSFERRIN; YOUNG ADULT;

EID: 84908124526     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c4mt00126e     Document Type: Article

References (40)

1. A. J. Bleyer S. K. Burke M. Dillon B. Garrett K. S. Kant D. Lynch S. N. Rahman P. Schoenfeld I. Teitelbaum S. Zeig E. Slatopolsky A comparison of a calcium free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in haemodialysis patients Am. J. Kidney Dis. 1999 33 694 701
2. P. C. D'Haese G. B. Spasovski A. Sikole A. Hutchison T. J. Freemont S. Sulkova C. Swanepoel S. Pejanovic L. Djukanovic A. Balducci G. Coen W. Sulowicz A. Ferreira A. Torres S. Curic M. Popovic N. Dimkovic M. E. De Broe A multicenter study on the effects of lanthanum carbonate (Fosrenol™) and calcium carbonate on renal bone disease in dialysis patients Kidney Int. 2003 63 S73 S78
3. B. Brezina W. Y. Qunibi C. R. Nolan Acid loading during treatment with sevelamer hydrochloride: mechanisms and clinical implications Kidney Int. 2004 66 suppl 90 S39 S45
4. A. J. Hutchison Oral phosphate binders Kidney Int. 2009 75 9 906 914
5. A. J. Hutchison B. Maes J. Vanwalleghem G. Asmus E. Mohamed R. Schmieder W. Backs R. Jamar A. Vosskühler Efficacy, tolerability, and safety of lanthanum carbonate in hyperphosphatemia: a 6 month, randomized, comparative trial versus calcium carbonate Nephron 2005 100 c8 c19
6. E. Slatopolsky H. Liapis J. Finch Progressive accumulation of lanthanum in the liver of normal and uremic rats Kidney Int. 2005 68 2809 2813
7. G. B. Spasovski A. Sikole S. Gelev J. Masin-Spasovska T. Freemont I. Webster M. Gill C. Jones M. E. De Broe P. C. D'Haese Evolution of bone and plasma concentration of lanthanum in dialysis patients before, during 1 year of treatment with lanthanum carbonate and after 2 years of follow-up Nephrol., Dial., Transplant. 2006 621 2217 2224
8. O. Hergesell E. Ritz Stabilized polynuclear iron hydroxide is an efficient oral phosphate binder in uraemic patients Nephrol., Dial., Transplant. 1999 14 863 867
9. O. Hergesell E. Ritz Phosphate binders on iron basis: a new perspective? Kidney Int. 1999 73 suppl S42 S45
10. G. A. Block S. L. Brillhart M. S. Persky A. Amer A. J. Slade Efficacy and safety of SBR759, a new iron-based phosphate binder Kidney Int. 2010 77 10 897 903
11. J. B. Chen S. S. Chiang H. C. Chen S. Obayashi M. Nagasawa J. M. Hexham A. Balfour G. Junge T. Akiba M. Fukagawa Efficacy and safety of SBR759, a novel calcium-free, iron(iii)-based phosphate binder, in Asian patients undergoing hemodialysis: A 12 week, randomized, open-label, dose-titration study versus sevelamer hydrochloride Nephrology 2011 16 8 743 750
12. M. Fukagawa H. Kasuga D. Joseph H. Sawata G. Junge A. Moore T. Akiba Efficacy and safety of SBR759, a novel calcium-free, iron(iii)-based phosphate binder, versus placebo in chronic kidney disease stage V Japanese patients on maintenance renal replacement therapy Clin. Exp. Nephrol. 2014 18 1 135 143 10.1007/s10157-013-0815-7
13. L. Sigg W. Stumm The interaction of anions and weak acids with the hydrous goethite (α-FeOOH) surface Colloids Surf. 1980 2 2 101 117
14. R. L. Parfitt R. J. Atkinson R. S. C. Smart The mechanism of phosphate fixation by iron oxides Soil Sci. Soc. Am. Proc. 1975 39 837 841
15. G. J. Anderson Mechanisms of iron loading and toxicity Am. J. Hematol. 2007 82 1128 1131
16. V. Chávez A. Mohri-Shiomi A. Maadani L. A. Vega D. A. Garsin Oxidative Stress Enzymes Are Required for DAF-16-Mediated Immunity Due to Generation of Reactive Oxygen Species by Caenorhabditis elegans Genetics 2007 176 3 1567 1577
17. T. Walczyk F. von Blanckenburg Deciphering the iron isotope message of the human body Int. J. Mass Spectrom. 2005 242 2-3 117 134
18. F. von Blanckenburg M. Oelze D. G. Schmid K. van Zuilen H.-P. Gschwind A. J. Slade S. Stitah D. Kaufmann P. Swart An iron stable isotope comparison between human erythrocytes and plasma Metallomics 10.1039/C4MT00124A
19. P. G. Whittaker T. Lind J. G. Williams A. L. Gray Inductively coupled plasma mass spectrometric determination of the absorption of iron in normal women Analyst 1989 114 6 675 678
20. J. F. R. Barrett P. G. Whittaker J. G. Williams T. Lind Absorption of non-heme iron in normal women measured by the incorporation of two stable isotopes into erythrocytes Clin. Sci. 1992 83 2 213 219
21. 58Fe) Am. J. Hematol. 1986 21 3 277 288
22. S. J. Fomon M. Janghorbani B. T. Ting E. E. Ziegler R. R. Rogers S. E. Nelson L. S. Ostedgaard B. B. Edwards Erythrocyte incorporation of ingested 58 iron by infants Pediatr. Res. 1988 24 1 20 24
23. S. J. Fomon E. E. Ziegler R. R. Rogers S. E. Nelson B. B. Edwards D. G. Guy J. C. Erve M. Janghorbani Iron absorption from infant foods Pediatr. Res. 1989 26 3 250 254
24. 58Fe, for determining availability of nonheme iron in meals Pediatr. Res. 1988 23 5 495 499
25. T. Walczyk L. Davidsson N. Zavaleta R. F. Hurrell Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal Fresenius' J. Anal. Chem. 1997 359 4-5 445 449
26. E. Vasquez Garibay I. Santos Torres S. E. Nelson E. E. Ziegler R. R. Rogers M. Janghorbani S. J. Fomon Iron absorption during recovery from malnutrition J. Am. Coll. Nutr. 2001 20 4 286 292
27. A. N. Halliday D. C. Lee J. N. Christensen M. Rehkämper W. Yi X. Luo C. M. Hall C. J. Ballentine T. Pettke C. Stirling Applications of multiple collector-ICPMS to cosmochemistry, geochemistry and paleoceanography Geochim. Cosmochim. Acta 1998 62 919 940
28. N. Jakubowski T. Prohaska F. Vanhaecke P. H. Roos T. Lindemann Inductively coupled plasma- and glow discharge plasma-sector field mass spectrometry J. Anal. At. Spectrom. 2011 26 727 757
29. B. S. Skikne N. Ahluwalia B. Fergusson A. Chonko J. D. Cook Effects of erythropoietin therapy on iron absorption in chronic renal failure J. Lab. Clin. Med. 2000 135 6 452 458
30. Institute for Reference Materials and Measurements, European Commission Joint Research Centre, Geel, Belgium, https://irmm.jrc.ec.europa.eu/refmat-pdf/IRMM-014-cert.pdf
31. R. Schoenberg F. von Blanckenburg An assessment of the accuracy of stable Fe isotope ratio measurements on samples with organic and inorganic matrices by high-resolution multicollector ICP-MS Int. J. Mass Spectrom. 2005 242 2-3 257 272
32. J. R. DeLaeter J. K. Boehlke P. De Bièvre H. Hidaka H. S. Peiser K. J. R. Rosman P. D. P. Taylor Atomic weights of the elements: Review 2000 (IUPAC technical report) Pure Appl. Chem. 2003 75 6 683 800
33. I. Bernat, Incorporation of radioiron into the erythroblasts and reticulocytes. Iron utilization in the course of red cell production. Effective erythropoiesis, in Iron Metabolism, ed., A. Kiado, Plenum Press, New York, 1983, ch. 14, pp. 167-181
34. F. von Blanckenburg J. Noordmann M. Guelke-Stelling The iron stable isotope fingerprint of the human diet J. Agric. Food Chem. 2013 61 11893 11899
35. Geigy, Scientific Tables, Geigy Scientific Tables, ed., C. Lentner, Physical Chemistry, Composition of blood, Hematology, Somatometric Data, Ciba-Geigy Limited, Medical Education Division, Ciba-Geigy Corporation, Basle, Switzerland, West Caldwell, New Jersey, 8th edn, 1984, vol. 3, pp. 65-67 and pp. 84-85
36. B. Davies T. Morris Physiological parameters in laboratory animals and humans Pharm. Res. 1993 10 7 1093 1095
37. M. C. Pruchnicki J. D. Coyle S. Hoshaw-Woodard W. H. Bay Effect of phosphate binders on supplemental iron absorption in healthy subjects J. Clin. Pharmacol. 2002 42 10 1171 1176
38. W. H. Hörl Iron therapy for renal anemia: how much needed, how much harmful Pediatr. Nephrol. 2007 22 480 489
39. P. Geisser E. Philipp PA21: A novel phosphate binder for the treatment of hyperphosphatemia in chronic kidney disease Clin. Nephrol. 2010 74 1 4 11
40. N. C. Andrews, in Principles of Molecular Medicine, ed., M. S. Runge, and, C. Patterson, Iron metabolism, Humana Press, Inc., Totowa, NJ, 2nd edn, 2007, ch. 87