Is OA a mechanical or systemic disease?

Nature Reviews Rheumatology

Volumn 10, Issue 9, 2014, Pages 515-516

  Cicuttini, Flavia M ^a   Wluka, Anita E ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR;

BIOMECHANICS; BODY MASS; FAT FREE MASS; GLUCOSE BLOOD LEVEL; HAND OSTEOARTHRITIS; HUMAN; IMAGE ANALYSIS; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MECHANICAL STRESS; METABOLIC SYNDROME X; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RISK ASSESSMENT; SHORT SURVEY; SYSTEMIC DISEASE;

BIOMECHANICAL PHENOMENA; CYTOKINES; HAND; HUMANS; INFLAMMATION; OBESITY; OSTEOARTHRITIS; OSTEOARTHRITIS, KNEE;

EID: 84908117124     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2014.114     Document Type: Short Survey

References (10)

1. Visser, A. W. et al. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: The NEO study. Ann. Rheum Dis. http://dx.doi.org/10.1136/annrheumdis-2013-205012 (2014).
2. Jones, G., Ding, C., Scott, F., Glisson, M. & Cicuttini, F. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage 12, 169-174 (2004).
3. Cicuttini, F. M., Jones, G., Forbes, A. & Wluka, A. E. Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: A prospective study. Ann. Rheum. Dis. 63, 1124-1127 (2004).
4. Stannus, O. et al. Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 18, 1441-1447 (2010).
5. Jin, X. et al. Circulating C reactive protein in osteoarthritis: A systematic review and meta-analysis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204494 (2013).
6. Roemer, F. W. et al. Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: The MOST study. Ann. Rheum. Dis. 70, 1804-1809 (2011).
7. Ding, C. et al. Association between leptin, body composition, sex and knee cartilage morphology in older adults: The Tasmanian older adult cohort (TASOAC) study. Ann. Rheum. Dis. 67, 1256-1261 (2008).
8. Tanamas, S. et al. Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum. 61, 459-467 (2009).
9. Carman, W. J., Sowers, M., Hawthorne, V. M. & Weissfeld, L. A. Obesity as a risk factor for osteoarthritis of the hand and wrist: A prospective study. Am. J. Epidemiol. 139, 119-129 (1994).
10. Massengale, M., Reichmann, W. M, Losina, E., Solomon, D. H. & Katz, J. N. The relationship between hand osteoarthritis and serum leptin concentration in participants of the Third National Health and Nutrition Examination Survey. Arthritis Res. Ther. 14, R132 (2012).