Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Engel, Nadja ^a   Falodun, Abiodun ^b   Kühn, Juliane ^a   Kragl, Udo ^c   Langer, Peter ^c   Nebe, Barbara ^a  

^a University Medical Center Rostock   (Germany)

^b UNIVERSITY OF BENIN   (Nigeria)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Adhesion; Anoikis; Apoptosis; Breast cancer; Cell cycle; Integrin; Plant extraction; Traditional medicine

Indexed keywords

ANTINEOPLASTIC AGENT; BETA1 INTEGRIN; FOCAL ADHESION KINASE; JATROPHA CURCAS EXTRACT; JATROPHA GOSSYPIFOLIA EXTRACT; PICRALIMA NITIDA EXTRACT; PLANT EXTRACT; PYRENACANTHA STAUDTII EXTRACT; UNCLASSIFIED DRUG;

ACTIN FILAMENT; AFRICAN; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL ADHESION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MCF 7 CELL LINE; NICK END LABELING; PROTEIN EXPRESSION; TREATMENT OUTCOME; AFRICAN MEDICINE; BREAST TUMOR; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; FEMALE; JATROPHA; METABOLISM; PATHOLOGY; PHYTOTHERAPY; PROCEDURES;

ANTIGENS, CD29; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL ADHESION; CELL CYCLE; CELL PROLIFERATION; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; JATROPHA; MCF-7 CELLS; MEDICINE, AFRICAN TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84908083819     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-334     Document Type: Article

References (28)

1. Cragg GM, Newman DJ. Antineoplastic agents from natural sources: achievements and future directions. Expert Opin Investig Drugs 2000, 9:2783-2797. 10.1517/13543784.9.12.2783, 11093353.
2. Falodun A, Qadir MI, Choudhary MI. Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii. Acta Pharm Sin 2009, 44:390-394.
3. Dalziel JM. The Useful Plants of West Tropical Africa 1961, London: In The Crown Agents.
4. Iwu MM. Hand book of African Medicinal Plants 1993, 219-221. U.S.A: CRC Press Inc.
5. Oliver B. Medical plants in Nigeria. Ibadan: Nigerian College of Arts, Science and Tech 1960, 23.
6. Wosu LO, Ibe CC. Use of extracts of Picralima nitida bark in the treatment of experimental trypanosomiasis: A preliminary study. J Ethnopharmacol 1989, 25:263-268. 10.1016/0378-8741(89)90032-9, 2747261.
7. Gill LS. Ethnomedical Uses of Plants in Nigeria 1992, Benin-City, Nigeria: In University of Benin Press.
8. Falodun A, Usifoh CO, Nworgu ZAM. Phytochemical analysis and inhibitory effect of Pyrenacantha staudtii leaf extract on isolated rat uterus. Pak J Pharm Sci 2005, 18:31-35.
9. Falodun A, Nworgu ZAM, Usifoh CO. Smooth muscle relaxant effect of 3-carbomethoxylpyridine from P. staudtii leaf on isolated rat uterus. Afri J Biotech 2006, 5:1271-1273.
10. Csurhes SM. Bellyache Bush (Jatropha Gossypifolia) in Queensland, Pest Status Review Series - Land Protection. Queensland Government Department of Natural Resources 1999, Brisbane: Qld.
11. Sastri BN. The Wealth of India. Raw Materials 1959, 5:295. New Delh: CSIR.
12. Das B, Das R. Medicinal properties and chemical constituents of Jatropha gossypifolia Linn. Ind Drugs 1994, 31:562-567.
13. Chatterjee A, Das B, Aditya Chaudhury N, Dabkirtaniya S. Jatrodien, a lignan from stems of Jatropha gossypifolia. Ind J Agric Sci 1980, 50:637-638.
14. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants 1956, 149. New Delhi: CSIR.
15. Muanza DN, Euler KL, Williams L, Newman DJ. Screening for antitumor and anti-HIV activities of nine medicinal plants from Zaire. Int J Pharmacog 1995, 33:98-106.
16. Evans WC. Phytochemical Screening and in Vitro Bioactivity of Medicinal Plants. Trease and Evans Pharmacognosy 2002, 214-393. London: W.B. Sanders, 15.
17. Engel N, Oppermann C, Falodun A, Kragl U. Proliferative effects of five traditional Nigerian medicinal plant extracts on human breast and bone cancer cell lines. J Ethnopharmacol 2011, 137:1003-1010. 10.1016/j.jep.2011.07.023, 21782919.
18. Nebe B, Peters A, Duske K, Richter DU, Briese V. Influence of phytoestrogens on the proliferation and expression of adhesion receptors in human and epithelial cells in vitro. Eur J Cancer Prev 2006, 15:405-415. 10.1097/00008469-200610000-00005, 16912569.
19. Johnson T. Ethnobotany Desk Reference 1999, Boca Raton, FL: In CRC Press.
20. Cordell GA, Beecher CW, Pezzuto JM. Can ethnopharmacology contribute to the development of new anticancer drugs?. J Ethnopharmacol 1991, 32:117-133. 10.1016/0378-8741(91)90110-Y, 1881151.
21. Alenzi FQ. Links between apoptosis, proliferation and the cell cycle. Br J Biomed Sci 2004, 61:99-102.
22. Cappelletti V, Fioravanti L, Miodini P, Di Fronzo G. Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle. J Cell Biochem 2000, 79:594-600. 10.1002/1097-4644(20001215)79:4<594::AID-JCB80>3.0.CO;2-4, 10996850.
23. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994, 124:619-626. 10.1083/jcb.124.4.619, 2119917, 8106557.
24. Boudreau N, Sympson CJ, Werb Z, Bissell MJ. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 1995, 267:891-893. 10.1126/science.7531366, 3004777, 7531366.
25. Pullan S, Wilson J, Metcalfe GM, Edwards N, Goberdhan J, Tilly JA, Hickman C, Dive CH, Streuli H. Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J Cell Sci 1996, 109:631-642.
26. Meredith JE, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993, 4:953-961. 10.1091/mbc.4.9.953, 275725, 8257797.
27. Wang P, Henning SM, Heber D. Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols. PLoS One 2010, 16:e10202.
28. Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010, 10:9-22. 10.1038/nrc2748, 20029421.