Gluconeogenesis in cancer: Door wide open

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages

  Leithner, Katharina ^a   Hrzenjak, Andelko ^a,b   Olschewski, Horst ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER INHIBITION; GLUCONEOGENESIS; HUMAN; LETTER; MALIGNANT NEOPLASTIC DISEASE; METABOLISM; ANIMAL; CELL NUCLEUS; GENETICS;

FORKHEAD TRANSCRIPTION FACTOR; PROTEIN P53; SIRTUIN;

ANIMALS; CELL NUCLEUS; FORKHEAD TRANSCRIPTION FACTORS; GLUCONEOGENESIS; HUMANS; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84908077934     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415680111     Document Type: Letter

References (5)

1. Zhang P, et al. (2014) Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proc Natl Acad Sci USA 111(29):10684-10689.
2. Schulze A, Harris AL (2012) How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 491(7424):364-373.
3. Leithner K, et al. (2014) PCK2 activation mediates an adaptive response to glucose depletion in lung cancer. Oncogene, 10.1038/onc.2014.47.
4. Méndez-Lucas A, Hyroššová P, Novellasdemunt L, Viñals F, Perales JC (2014) Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability. J Biol Chem 289(32):22090-22102.
5. Stark R, Kibbey RG (2014) The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: Has it been overlooked? Biochim Biophys Acta 1840(4):1313-1330.