Hypoxically preconditioned human peripheral blood mononuclear cells improve blood flow in hindlimb ischemia xenograft model

American Journal of Translational Research

Volumn 6, Issue 5, 2014, Pages 570-579

  Kudo, Tomoaki ^a   Kubo, Masayuki ^a,b   Katsura, Shunsaku ^a   Nishimoto, Arata ^a   Ueno, Koji ^a   Samura, Makoto ^a   Fujii, Yasuhiko ^a   Hosoyama, Tohru ^a   Hamano, Kimikazu ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cell Based therapy; Hindlimb ischemia; Human peripheral blood mononuclear cells; Hypoxic preconditioning; Therapeutic angiogenesis

Indexed keywords

CD31 ANTIGEN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOWMETRY; CELL ADHESION; CELL ADHESION ASSAY; CELL CULTURE; CELL HYPOXIA; CELL ISOLATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; HINDLIMB; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LASER DOPPLER FLOWMETRY; LIMB BLOOD FLOW; LIMB ISCHEMIA; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; UPREGULATION;

EID: 84908066867     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Losordo DW and Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines. Circulation 2004; 109: 2487-2491.
2. Isner JM and Feldman LJ. Gene therapy for arterial disease. Lancet 1994; 344: 1653-1654.
3. Henry F, Paquet P, Pierard-Franchimont C and Pierard GE. [Leg heaviness and stasis microangiopathy. Preventive and therapeutic approaches]. Rev Med Liege 2003; 58: 435-438.
4. Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, Masaki H, Amano K, Kishimoto Y, Yoshimoto K, Akashi H, Shimada K, Iwasaka T, Imaizumi T; Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 2002; 360: 427-435.
5. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G and Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-967.
6. Hojo Y, Ikeda U, Zhu Y, Okada M, Ueno S, Arakawa H, Fujikawa H, Katsuki T and Shimada K. Expression of vascular endothelial growth factor in patients with acute myocardial infarction. J Am Coll Cardiol 2000; 35: 968-973.
7. Minamino T, Toko H, Tateno K, Nagai T and Komuro I. Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis? Lancet 2002; 360: 2083-2084; author reply 2084.
8. Moriya J, Minamino T, Tateno K, Shimizu N, Kuwabara Y, Sato Y, Saito Y and Komuro I. Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia. Circ Cardiovasc Interv 2009; 2: 245-254.
9. Akita T, Murohara T, Ikeda H, Sasaki K, Shimada T, Egami K and Imaizumi T. Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization. Lab Invest 2003; 83: 65-73.
10. Kubo M, Li TS, Suzuki R, Shirasawa B, Morikage N, Ohshima M, Qin SL and Hamano K. Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance. Am J Physiol Heart Circ Physiol 2008; 294: H590-595.
11. Kubo M, Li TS, Kamota T, Ohshima M, Qin SL and Hamano K. Increased expression of CXCR4 and integrin alphaM in hypoxia-preconditioned cells contributes to improved cell retention and angiogenic potency. J Cell Physiol 2009; 220: 508-514.
12. Li TS, Hamano K, Suzuki K, Ito H, Zempo N and Matsuzaki M. Improved angiogenic potency by implantation of ex vivo hypoxia prestimulated bone marrow cells in rats. Am J Physiol Heart Circ Physiol 2002; 283: H468-473.
13. Efimenko A, Starostina E, Kalinina N and Stolzing A. Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning. J Transl Med 2011; 9: 10.
14. Leroux L, Descamps B, Tojais NF, Seguy B, Oses P, Moreau C, Daret D, Ivanovic Z, Boiron JM, Lamaziere JM, Dufourcq P, Couffinhal T and Duplaa C. Hypoxia preconditioned mesenchymal stem cells improve vascular and skeletal muscle fiber regeneration after ischemia through a Wnt4-dependent pathway. Mol Ther 2010; 18: 1545-1552.
15. Kudo T, Hosoyama T, Samura M, Katsura S, Nishimoto A, Kugimiya N, Fujii Y, Li TS and Hamano K. Hypoxic preconditioning reinforces cellular functions of autologous peripheral blood-derived cells in rabbit hindlimb ischemia model. Biochem Biophys Res Commun 2014; 444: 370-375.
16. Kubo M, Li TS, Kurazumi H, Takemoto Y, Ohshima M, Murata T, Katsura S, Morikage N, Furutani A and Hamano K. Hypoxic preconditioning enhances angiogenic potential of bone marrow cells with aging-related functional impairment. Circ J 2012; 76: 986-994.
17. Kalra VK, Shen Y, Sultana C and Rattan V. Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. Am J Physiol 1996; 271: H2025-2034.
18. Winning S, Splettstoesser F, Fandrey J and Frede S. Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule- 1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B. J Immunol 2010; 185: 1786-1793.
19. Zund G, Uezono S, Stahl GL, Dzus AL, McGowan FX, Hickey PR and Colgan SP. Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes. Am J Physiol 1997; 273: C1571-1580.
20. Kim MH, Jin E, Zhang HZ and Kim SW. Robust angiogenic properties of cultured human peripheral blood-derived CD31(+) cells. Int J Cardiol 2013; 166: 709-715.
21. Kim SW, Kim H, Cho HJ, Lee JU, Levit R and Yoon YS. Human peripheral blood-derived CD31+ cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease. J Am Coll Cardiol 2010; 56: 593-607.
22. Malladi P, Xu Y, Chiou M, Giaccia AJ and Longaker MT. Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol 2006; 290: C1139-1146.
23. Merceron C, Vinatier C, Portron S, Masson M, Amiaud J, Guigand L, Cherel Y, Weiss P and Guicheux J. Differential effects of hypoxia on osteochondrogenic potential of human adipose- derived stem cells. Am J Physiol Cell Physiol 2010; 298: C355-364.
24. Huang PP, Yang XF, Li SZ, Wen JC, Zhang Y and Han ZC. Randomised comparison of G-CSF-mobilized peripheral blood mononuclear cells versus bone marrow-mononuclear cells for the treatment of patients with lower limb arteriosclerosis obliterans. Thromb Haemost 2007; 98: 1335-1342.