Absence of nonprimate hepacivirus-related genomes in blood donors seroreactive for hepatitis C virus displaying indeterminate blot patterns

Journal of Viral Hepatitis

Volumn 21, Issue 11, 2014, Pages e164-e166

  Levi, J E ^a,b,c   Cabral, S P N ^a   Nishiya, A ^b,d   Ferreira, S ^b,d   Romano, C M ^c   Polite, M B C ^a   Pereira, R A A ^a   Mota, M A ^a   Kutner, J M ^a  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b FUNDAÇÃO PRÓ SANGUE HEMOCENTRO DE SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

blood donors; blot indeterminates; hepatitis C virus; nonprimate hepacivirus

Indexed keywords

COMPLEMENTARY DNA; MONTIRELIN; NONSTRUCTURAL PROTEIN 5; VIRUS RNA; HEPATITIS ANTIBODY; PRIMER DNA;

5' UNTRANSLATED REGION; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; CROSS REACTION; HEPATITIS C VIRUS; HEPATITIS G VIRUS; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; NON PRIMATE HEPACIVIRUS; RNA VIRUS; SEROLOGY TEST KIT; VIRUS GENOME; BLOOD; GENETICS; HEPACIVIRUS; IMMUNOLOGY; ISOLATION AND PURIFICATION; POLYMERASE CHAIN REACTION; PROCEDURES;

BLOOD DONORS; CROSS REACTIONS; DNA PRIMERS; HEPACIVIRUS; HEPATITIS ANTIBODIES; HUMANS; IMMUNOBLOTTING; POLYMERASE CHAIN REACTION; RNA, VIRAL;

EID: 84908049522     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12252     Document Type: Article

References (11)

1. Stapleton JT, Foung S, Muerhoff AS, Bukh J, Simmonds P,. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J Gen Virol 2011; 92: 233-246.
2. Kapoor A, Simonds P, Gerold G, et al,. Characterization of a canine homolog of hepatitis C virus. PNAS 2011; 108: 11608-11613.
3. Burbelo PD, Dubovi EJ, Simmonds P, et al,. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol 2012; 86: 6171-6178.
4. Makuria AT, Raghuraman S, Burbelo PD, et al,. The clinical relevance of persistent recombinant immunoblot assay-indeterminate reactions: insights into the natural history of hepatitis C virus infection and implications for donor counseling. Transfusion 2012; 52: 1940-1948.
5. Maidana-Giret MT, Silva TM, Sauer MM, et al,. GB virus type C infection modulates T-cell activation independently of HIV-1 viral load. AIDS 2009; 23: 2277-2287.
6. Simmons P,. The origin of hepatitis C virus. Curr Top Microbiol Immunol 2013; 369: 1-15.
7. Kapoor A, Simmonds P, Scheel TKH, et al,. Identification of rodent homologs of hepatitis C virus and pegiviruses. MBio 2013; 4 (2): e00216-13.
8. Levi JE, Contri DG, Lima LP, et al,. High prevalence of GB virus C/hepatitis G virus RNA among Brazilian blood donors. Rev Inst Med Trop Sao Paulo 2003; 45: 75-78.
9. Johnson N, Wakeley PR, Mansfield KL, et al,. Assessment of a novel real-time pan-flavivirus RT-polymerase chain reaction. Vector Borne Zoonotic Dis 2010; 10: 665-671.
10. Muerhoff AS, Simons JN, Erker JC, Desai SM, Mushahwar IK,. Identification of conserved nucleotide sequences within the GB virus C 5′-untranslated region: design of PCR primers for detection of viral RNA. J Virol Methods 1996; 62: 55-62.
11. Linnen J, Wages J Jr, Zhang-Keck ZY, et al,. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science 1996; 271: 505-508.