Prospects for developing an accurate diagnostic biomarker panel for low prevalence cancers

Theoretical Biology and Medical Modelling

Volumn 11, Issue 1, 2014, Pages

  Firpo, Matthew A ^a   Boucher, Kenneth M ^a   Mulvihill, Sean J ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Accuracy; Biomarker; False positive diagnoses; Low prevalence cancer; Pancreatic cancer; Strong classifier panel; Weak classifier

Indexed keywords

TUMOR MARKER;

ADULT; BIOLOGICAL MODEL; BLOOD; CARCINOMA, PANCREATIC DUCTAL; CASE CONTROL STUDY; HUMAN; METABOLISM; PANCREATIC NEOPLASMS; PREVALENCE; SENSITIVITY AND SPECIFICITY;

ADULT; CARCINOMA, PANCREATIC DUCTAL; CASE-CONTROL STUDIES; HUMANS; MODELS, BIOLOGICAL; PANCREATIC NEOPLASMS; PREVALENCE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84908028550     PISSN: None     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/1742-4682-11-34     Document Type: Article

References (18)

1. Cancer statistics, 2014. Siegel R, Ma J, Zou Z, Jemal A, CA Cancer J Clin 2014 64 9 29
2. The clinical utility of CA 19-9 in pancreatic adenocarcinoma: diagnostic and prognostic updates. Poruk KE, Gay DZ, Brown K, Mulvihill JD, Boucher KM, Scaife CL, Firpo MA, Mulvihill SJ, Curr Mol Med 2013 13 340 351
3. Costs and Trends in Pancreatic Cancer Treatment. O'Neill CB, Atoria CL, O'Reilly EM, Lafemina J, Henman MC, Elkin EB, Cancer 2012 epub ahead of print
4. Screening for pancreatic cancer: why, how, and who? Poruk KE, Firpo MA, Adler DG, Mulvihill SJ, Ann Surg 2013 257 17 26
5. Serum Biomarker Panels for the Detection of Pancreatic Cancer. Brand RE, Nolen BM, Zeh HJ, Allen PJ, Eloubeidi MA, Goldberg M, Elton E, Arnoletti JP, Christein JD, Vickers SM, Langmead CJ, Landsittel DP, Whitcomb DC, Grizzle WE, Lokshin AE, Clin Cancer Res 2011 17 805 816
6. Improved Diagnosis of Pancreatic Adenocarcinoma using Haptoglobin and Serum Amyloid A in a Panel Screen. Firpo MA, Gay DZ, Granger SR, Scaife CL, DiSario JA, Boucher KM, Mulvihill SJ, World J Surg 2009 33 716 722
7. Screening for Early Pancreatic Ductal Adenocarcinoma: An Urgent Call! Lee MX, Saif MW, JOP 2009 10 104 108
8. Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study. Nolen BM, Brand RE, Prosser D, Velikokhatnaya L, Allen PJ, Zeh HJ, Grizzle WE, Lomakin A, Lokshin AE, PLoS One 2014 9 94928
9. Identification of Serum Biomarker Signatures Associated with Pancreatic Cancer. Wingren C, Sandstrom A, Segersvard R, Carlsson A, Andersson R, Lohr M, Borrebaeck CA, Cancer Res 2012 72 2481 2490
10. Diagnostic, Prognostic, and Predictive Biomarkers in Pancreatic Cancer. Winter JM, Yeo CJ, Brody JR, J Surg Oncol 2012 epub ahead of print
11. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, et al. Science 2008 321 1801 1806
12. Molecular Biology. Genetic Events that Shape the Cancer Epigenome. Ryan RJ, Bernstein BE, Science 2012 336 1513 1514
13. Bagging Predictors. Breiman L, Mach Learn 1996 24 123 140
14. Random Forests. Breiman L, Mach Learn 2001 45 23 37
15. The Strength of Weak Learnability. Schapire RE, Mach Learn 1990 5 197 227
16. A Compendium of Potential Biomarkers of Pancreatic Cancer. Harsha HC, Kandasamy K, Ranganathan P, Rani S, Ramabadran S, Gollapudi S, Balakrishnan L, Dwivedi SB, Telikicherla D, Selvan LD, Goel R, Mathivanan S, Marimuthu A, Kashyap M, Vizza RF, Mayer RJ, Decaprio JA, Srivastava S, Hanash SM, Hruban RH, Pandey A, PLoS Med 2009 6 1000046
17. Serum osteopontin and tissue inhibitor of metalloproteinase 1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma. Poruk KE, Firpo MA, Scaife CL, Adler DG, Emerson LL, Boucher KM, Mulvihill SJ, Pancreas 2013 42 193 197
18. Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression. Fukuda A, Wang SC, Morris JP IV, Folias AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M, Cancer Cell 2011 19 441 455