Peginterferon-alfa mono-therapy in the treatment of acute hepatitis C in HIV-infection

Journal of Viral Hepatitis

Volumn 21, Issue 11, 2014, Pages 780-785

  Boesecke, C ^a,b   Van Assen, S ^c   Stellbrink, H J ^d   Baumgarten, A ^e   Ingiliz, P ^e   Strassburg, C P ^a,b   Schwarze Zander, C ^a,b   Wasmuth, J C ^a,b   Hoepelman, A I M ^f   Rockstroh, J K ^a,b   Arends, J E ^f  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d Infektionsmedizinisches Centrum Hamburg   (Germany)

^e Medical Center for Infectious Diseases   (Germany)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

acute hepatitis C; HIV; pegylated interferon mono therapy

Indexed keywords

PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN; VIRUS RNA; ALPHA INTERFERON; ANTIVIRUS AGENT; MACROGOL DERIVATIVE; RECOMBINANT PROTEIN;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; COMBINATION CHEMOTHERAPY; DISEASE TRANSMISSION; DRUG EFFICACY; GENOTYPE; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; MIXED INFECTION; MONOTHERAPY; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; BLOOD; COMPLICATION; EUROPE; HIV INFECTIONS; MIDDLE AGED; PROCEDURES; TIME; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ANTIVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; EUROPE; HEPATITIS C; HIV INFECTIONS; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN; RNA, VIRAL; TIME FACTORS; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84908021279     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12272     Document Type: Article

References (32)

1. Browne R, Asboe D, Gilleece Y, et al,. Increased numbers of acute hepatitis C infections in HIV positive homosexual men: is sexual transmission feeding the increase? Sex Transm Infect 2004; 80: 326-327.
2. Gambotti L, Batisse D, Colin-de-Verdiere N, et al,. Acute hepatitis C infection in HIV positive men who have sex with men in Paris, France, 2001-2004. Euro Surveill 2005; 10: 115-117.
3. Giraudon I, Ruf M, Maguire H, et al,. Increase in diagnosed newly acquired hepatitis C in HIV-positive men who have sex with men across London and Brighton, 2002-2006: is this an outbreak? Sex Transm Infect 2008; 84: 111-115.
4. Rauch A, Rickenbach M, Weber R, et al,. Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 2005; 41: 395-402.
5. Ruf M, Cohuet S, Maguire H, et al,. Setting up an enhanced surveillance of newly acquired hepatitis C infection in men who have sex with men: a pilot in London and South East region of England. Euro Surveill 2008; 13 (47): pii: 19042.
6. Urbanus AT, van de Laar TJ, Stolte IG, et al,. Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009; 23: F1-F7.
7. Vogel M, Deterding K, Wiegand J, et al,. Initial presentation of acute hepatitis C virus (HCV) infection among HIV-negative and HIV-positive individuals: experience from 2 large German networks on the study of acute HCV infection. Clin Infect Dis 2009; 49: 317-319; author reply 9.
8. Gallotta G, Gali L, De Bona A, et al,. Acute hepatitis C virus in HIV co-infected men who have sex with men: Milan, 1996-2007. In: 4th International HIV and Hepatitis Co-infection; Madrid, Spain; 2008; abstract 47.
9. Larsen C, Alric L, Auperin I, et al,. Acute hepatitis C in HIV-infected men who have sex with men in France in 2006 and 2007. In: 58th Annual Meeting of the American Association for the Study of the Liver, Boston, USA; 2007; abstract 894.
10. Clausen LN, Weis N, Astvad K, et al,. Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. J Viral Hepat 2011; 18 (4): e66-e74.
11. Bottieau E, Apers L, Van Esbroeck M, et al,. Hepatitis C virus infection in HIV-infected men who have sex with men: sustained rising incidence in Antwerp, Belgium, 2001-2009. Euro Surveill 2010; 15 (39): 19673.
12. Fierer D, Fishman S, Uriel A, et al,. Characterization of an outbreak of acute HCV infection in HIV-infected men in New York city. In: 16th Conference on Retroviruses and Opportunistic Infections; Montreal, Canada; 2009; abstract 802.
13. Luetkemeyer A, Hare CB, Stansell J, et al,. Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. J Acquir Immune Defic Syndr 2006; 41: 31-36.
14. Matthews G, Hellard M, Haber P, et al,. Characteristics and treatment outcomes among HIV-infected individuals in the Australian trial in acute hepatitis C. Clin Infect Dis 2009; 48: 650-658.
15. Yaphe S, Bozinoff N, Kyle R, Shivkumar S, Pai NP, Klein M,. Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review. Sex Transm Infect 2012; 88 (7): 558-564.
16. Boesecke C, Wedemeyer H, Rockstroh JK,. Diagnosis and treatment of acute hepatitis C virus infection. Infect Dis Clin North Am 2012; 26 (4): 995-1010.
17. van de Laar TJ, Paxton WA, Zorgdrager F, et al,. Sexual transmission of hepatitis C virus in human immunodeficiency virus-negative men who have sex with men: a series of case reports. Sex Transm Dis 2011; 38 (2): 102-104.
18. Schmidt AJ, Rockstroh JK, Vogel M, et al,. Trouble with bleeding: risk factors for acute hepatitis C among HIV-positive gay men from Germany-a case-control study. PLoS One 2011; 6 (3): e17781.
19. Arends JE, Lambers FA, van der Meer JT, et al,. Treatment of acute hepatitis C virus infection in HIV+ patients: Dutch recommendations for management. Neth J Med 2011; 69 (1): 43-49.
20. The European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel. Acute hepatitis C in HIV-infected individuals: recommendations from the European AIDS Treatment Network (NEAT) consensus conference. AIDS 2011; 25 (4): 399-409.
21. Gilleece YC, Browne RE, Asboe D, et al,. Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin. J Acquir Immune Defic Syndr 2005; 40: 41-46.
22. Matthews G, Grebely J, Hellard M, et al,. Differences in early virological decline in individuals treated within the Australian trial in acute HCV suggest a potential benefit for the use of ribavirin. In: 45th Annual Meeting of the European Association for the Study of the Liver (EASL). Vienna, Austria; 2010: Abstract O60.
23. Lambers F, Brinkman K, Schinkel J, et al,. Treatment of acute hepatitis C virus infection in HIV-infected MSM: the effect of treatment duration. AIDS 2011; 25 (10): 1333-1336.
24. Vogel M, Nattermann J, Baumgarten A, et al,. Pegylated interferon-alpha for the treatment of sexually transmitted acute hepatitis C in HIV-infected individuals. Antivir Ther 2006; 11: 1097-1101.
25. Arends JE, van Assen S, Stek CJ, et al,. Pegylated interferon-α monotherapy leads to low response rates in HIV-infected patients with acute hepatitis C. Antivir Ther 2011; 16 (7): 979-988.
26. Boesecke C, Ingiliz P, Stellbrink HJ, et al,. Ribavirin is needed in addition to pegylated interferon for optimal treatment responses in the treatment of acute HCV genotype 2 and 3 infection in HIV co-infected individuals. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, U.S.A. 2012, Abstract #Q-133.
27. Ge D, Fellay J, Thompson AJ, et al,. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461 (7262): 399-401.
28. Deterding K, Gruner NH, Buggisch P, et al,. Early versus delayed treatment of acute hepatitis C: the German HEP-NET Acute HCV-III study-a randomized controlled trial. 47th Annual Meeting of the European Association for the Study of the Liver (EASL). Barcelona, Spain; 2012.Abstract 48.
29. Grebely J, Hellard M, Applegate T, et al,. Virological responses during treatment for recent hepatitis C virus: potential benefit for ribavirin use in HCV/HIV co-infection. AIDS 2012; 26 (13): 1653-1661.
30. Jones M, Núñez M,. HIV and hepatitis C co-infection: the role of HAART in HIV/hepatitis C virus management. Curr Opin HIV AIDS 2011; 6 (6): 546-552.
31. Lauer GM, Barnes E, Lucas M, et al,. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004; 127 (3): 924-936.
32. Fierer DS, Dieterich DT, Mullen MP, et al,. Telaprevir in the treatment of acute hepatitis C virus infection in HIV-infected men. Clin Infect Dis 2014; 58 (6): 873-879.