Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as antibreast cancer agents through microtubule stabilization

European Journal of Medicinal Chemistry

Volumn 86, Issue 1, 2014, Pages 740-751

  Kumar, B Sathish ^a   Kumar, Amit ^b   Singh, Jyotsna ^b   Hasanain, Mohammad ^b   Singh, Arjun ^a   Fatima, Kaneez ^a   Yadav, Dharmendra K ^a   Shukla, Vinay ^b   Luqman, Suaib ^a   Khan, Feroz ^a   Chanda, Debabrata ^a   Sarkar, Jayanta ^b   Konwar, Rituraj ^b   Dwivedi, Anila ^b   Negi, Arvind S ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Acute oral toxicity; Antiestrogenicity; Breast cancer; Cell cycle; Estrogenicity; Microtubule stabilization

Indexed keywords

2 (3,4,5 TRIMETHOXYBENZYLOXY) ESTRA 1,3,5(10) TRIEN 3,17 DIOL; 2 METHOXYESTRADIOL; ANTINEOPLASTIC AGENT; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; ESTRADIOL;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL LINE; CELL CYCLE ARREST; CONFOCAL MICROSCOPY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE; MOLECULAR DOCKING; ANALOGS AND DERIVATIVES; ANIMAL; BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FEMALE; HEK293 CELL LINE; MALE; MCF 7 CELL LINE; METABOLISM; MOUSE; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESTRADIOL; FEMALE; HEK293 CELLS; HUMANS; MALE; MCF-7 CELLS; MICE; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908018079     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.033     Document Type: Article

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