Treatment of chronic venous leg ulcers with a hand-held DBD plasma generator

Plasma Medicine

Volumn 2, Issue 1-3, 2012, Pages 19-32

  Emmert, Steffen ^a   Brehmer, Franziska ^a   Hänßle, Holger ^a   Helmke, Andreas ^b   Mertens, Nina ^b   Ahmed, Raees ^c   Simon, Dirk ^c   Wandke, Dirk ^d   Schön, Michael P ^a   Maus Friedrichs, Wolfgang ^e   Viöl, Wolfgang ^b,f   Däschlein, Georg ^g  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b HAWK UNIVERSITY OF APPLIED SCIENCES AND ARTS   (Germany)

^c Institute for Applied Research and Clinical Studies (IFS GmbH)   (Germany)

^d CINOGY GMBH   (Germany)

^e CLAUSTHAL UNIVERSITY OF TECHNOLOGY   (Germany)

^f FRAUNHOFER INSTITUTE FOR SURFACE ENGINEERING AND THIN FILMS IST   (Germany)

^g UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Chronic wounds; Cold atmospheric pressure plasma (CAP); Electric current; Reactive gas species; Ultraviolet radiation

Indexed keywords

ULTRAVIOLET RADIATION;

ATMOSPHERIC PRESSURE PLASMAS; CHRONIC WOUNDS; DBD PLASMA; REACTIVE GAS; VENOUS LEG ULCERS;

ELECTRIC CURRENTS;

REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ACIDIFICATION; ARTICLE; CLINICAL TRIAL (TOPIC); COLD ATMOSPHERIC PRESSURE PLASMA; DERMATOLOGICAL EQUIPMENT; DEVICE SAFETY; DIELECTRIC BARRIER DISCHARGE PLASMA GENERATOR; ELECTRIC CURRENT; ELECTRIC FIELD; GENERATOR; HUMAN; LEG ULCER; MEDICAL DEVICE COMPLICATION; MICROCIRCULATION; SKIN DECONTAMINATION; SKIN DEFECT; THERMOREGULATION; TISSUE REGENERATION; ULTRAVIOLET RADIATION; WOUND HEALING;

EID: 84907978685     PISSN: 19475764     EISSN: 19475772     Source Type: Journal    
DOI: 10.1615/PlasmaMed.2013005914     Document Type: Article

References (54)

1. Crookes W. The Bakerian Lecture: on radiant matter spectroscopy. A new method of spectrum analysis. Proc Roy Soc London. 1983;35:262-71.
2. Heinlin J, Morfill G, Landthaler M, Stolz W, Isbary G, Zimmermann JL, Shimizu T, Karrer S. Plasma medicine: possible applications in dermatology. J Dtsch Dermatol Ges. 2010;8:968-76.
3. Heinlin J, Isbary G, Stolz W, Morfill G, Landthaler M, Shimizu T, Steffens B, Nosenko T, Zimmermann JL, Karrer S. Plasma applications in medicine with a special focus on dermatology. J Eur Acad Dermatol Venereol. 2011;25:1-11.
4. Ramakrishnan S, Rogozinski MW. Properties of electric arc plasma for metal cutting. J Phys D Appl Phys. 1997;30:636-44.
5. Semenov S, Cetegen B. Spectroscopic temperature measurements in direct current arc plasma jets used in thermal spray processing of materials. J Therm Spray Techn. 2001;10:326-36.
6. Bogle MA, Arndt KA, Dover JS. Evaluation of plasma skin regeneration technology in lowenergy full-facial rejuvenation. Arch Dermatol. 2007;143:168-74.
7. Elsaie ML, Kammer JN. Evaluation of plasma skin regeneration technology for cutaneous remodeling. J Cosmet Dermatol. 2008;7:309-11.
8. Foster KW, Moy RL, Fincher EF. Advances in plasma skin regeneration. J Cosmet Dermatol. 2008;7:169-79.
9. Kilmer S, Fitzpatrick R, Bernstein E, Brown D. Long term follow-up on the use of plasma skin regeneration (PSR) in full facial rejuvenation procedures. Lasers Surg Med. 2005;36:22.
10. Kilmer S, Semchyshyn N, Shah G, Fitzpatrick R. A pilot study on the use of a plasma skin regeneration device (Portrait PSR3) in full facial rejuvenation procedures. Lasers Med Sci. 2007;22:101-9.
11. Shimizu T, Steffes B, Pompl R, Jamitzky F, Bunk W, Ramrath K, Georgi M, Stolz W, Schmidt HU, Urayama T, Fujii S, Morfill GE. Characterization of microwave plasma torch for decontamination. Plasma Process Polym. 2008;5:577-82.
12. Sladek RE, Stoffels E. Deactivation of Escherichia coli by the plasma needle. J Phys D Appl Phys. 2005;38:1716-21.
13. von Siemens W. Ozone production in an atmospheric-pressure dielectric barrier discharge. Pogg Ann. 1857;102:66-122.
14. Helmke A, Hoffmeister D, Mertens N, Emmert S, Schuette J, Vioel W. The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air. New J Phys. 2009;11:115-25.
15. Gesche R, Awakowicz P, Bibinov N, Born M, Niemann U, Busse B, Porteanu HE, Kühn S, Helmke A, Kaemling A, Mertens N, Vioel W, Wandke D, Kolb-Bachofen V, Liebmann J, Kovacs R, Scherer J, Oplaender C, Suschek C. Biological stimulation of the human skin applying health-promoting light and plasma sources. Contrib Plasma Phys. 2009;49:641-7.
16. Helmke A, Gruening P, Fritz U, Wandke D, Emmert S, Petersen K, Vioel W. Low-temperature plasma-a prospective microbicidal tool. Recent Pat Antiinfect Drug Discov. 2012;7(3):223-30.
17. Marschewski M, Hirschberg J, Omairi T, Höfft O, Viöl W, Emmert S, Maus-Friedrichs W. Electron spectroscopic analysis of the human lipid skin barrier: plasma-induced changes in lipid composition. Exp Dermatol. 2012;21:921-5.
18. Rossaint R, Falke KJ, Lopes F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993;328:399-405.
19. Rajasekaran P, Mertmann P, Bibinov N, Wandke D, Viöl W, Awakowicz P. DBD plasma source operated in single-filamentary mode for therapeutic use in dermatology. J Phys D Appl Phys. 2009;42:1-8.
20. Tümmel S, Mertens N, Wang J, Viöl W. Low temperature plasma treatment of living human cells. Plasma Process Polym. 2007;4:465-9.
21. Valacchi G, Fortino V, Bocci V. The dual action of ozone in the skin. Br J Dermatol. 2005;153:1096-100.
22. Skomro P, Opalko K, Gadomska-Krasny J, Lietz-Kijak D, Perzanowska-Stefanska M. Ozone therapy with the OzonyTron apparatus. Ann Acad Med Stetin. 2005;51:39-42.
23. Martinez-Sanchez G, Al-Dalain AM, Menendez S, Re L, Giuliani A, Candelario-Jalil E, Alvarez H, Fernadez-Montequin JI, Leon OS. Therapeutic efficacy of ozone on patients with diabetic foot. Eur J Pharmacol. 2005;253:151-61.
24. Kreyden OP. Iontophoresis for palmoplantar hyperhidrosis. J Cosmet Dermatol. 2004;3:211-4.
25. Vorkamp T, Foo FJ, Khan S, Schmitto JD, Wilson P. Hyperhydrosis: evolving concepts and a comprehensive review. Surgeon. 2010;8:287-92.
26. Power I. Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain. Br J Anaesth. 2007;98:4-11.
27. Hölzle E, Hönigsmann H, Röcken M, Ghoreschi K, Lehmann P. Empfehlungen zur Phototherapie und Photochemotherapie. J Dtsch Dermatol Ges. 2003;1:985-97.
28. Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004;113:651-7.
29. International Commission on Non-Ionizing Radiation Protection. Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400 nm (incoherent optical radiation). Health Phys. 2004;87:171-86.
30. Wandke D. [Medically useful effects by a dielectric barrier discharge (DBD): studies on application security and treatment options] [dissertation in German]. Greifswald, Germany: Ernst-Moritz-Arndt-Universität Greifswald; 2011.
31. Daeschlein G, von Woedtke T, Kindel E, Brandenburg R, Weltmann KD, Jünger M. Antibacterial activity of an atmospheric pressure plasma jet against relevant wound pathogens in vitro on a simulated wound environment. Plasma Process Polym. 2010;7:224-30.
32. Daeschlein G, Scholz S, Arnold A, von Podewils S, Haase H, Emmert S, von Woedtke T, Weltmann KD, Jünger M. In vitro susceptibility of important skin and wound pathogens against low temperature atmospheric pressure plasma jet (APPJ) and dielectric barrier discharge plasma (DBD). Plasma Process Polym. 2012;9:380-9.
33. Helmke A, Hoffmeister D, Berge F, Emmert S, Laspe P, Mertens N, Vioel W, Weltmann K-D. Physical and microbiological characterization of Staphylococcus epidermidis inactivation by dielectric barrier discharge. Plasma Process Polym. 2011;8:278-86.
34. Isbary G, Heinlin J, Shimizu T, Zimmermann JL, Morfill G, Schmidt HU, Monetti R, Steffes B, Bunk W, Li Y, Klaempfl T, Karrer S, Landthaler M, Stolz W. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br J Dermatol. 2012;167:404-10.
35. Fritsch P. Dermatologie und Venerologie. Berlin: Springer; 1998
36. Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A. Applied plasma medicine. Plasma Process Polym. 2008;5:503-33.
37. Viöl, W. http://opac.tib.uni-hannover.de/%20DB=1/SET=3/TTL=8/CMD?ACT=SRCHA&IKT=1016&SRT=YOP&TRM=biolipVerbundprojekt: Desinfektion, Entkeimung und biologische Stimulation der menschlichen Haut durch gesundheitsfördernde Licht-und Plasmaquellen : Akronym: BioLiP ; Thema des Teilvorhabens: Grundlegende Untersuchung einer kompakten und effizienten Versorgung für eine Plasmaquelle ; Zeitraum: 01. August 2006 bis 31. Dezember 2009
38. Awakowicz P, Bibinov N, Born M, Busse B, Gesche R, Helmke H, Kaemling A, Kolb Bachofen V, Kovacs R, Kuehn S, Liebmann J, Mertens N, Niemann U, Oplaender C, Porteanu H-E, Scherer J, Suschek C, Vioel W, Wandke D. Biological stimulation of the human skin applying health-promoting light and plasma sources. Contrib Plasma Phys. 2009;49:641-7.
39. Wandke, D. Abschlussbericht BioLip Cinogy GmbH: http://opac.tib.uni-hannover.de/%20DB=1/SET=3/TTL=8/CMD?ACT=SRCHA&IKT=1016&SRT=YOP&TRM=biolip+cinogyAbschlussbericht zum BMBF-Verbundprojekt “Desinfektion, Entkeimung und biologische Stimulation der menschlichen Haut durch gesundheitsfördernde Licht-und Plasmaquellen (BioLiP)” : Grundlegende Erforschung einer Plasmaquelle auf Basis einer Barrierenentladung für Anwendungen auf lebendem biologischem Gewebe ; 01. August 2006 bis 31. Dezember 2009
40. Rajasekaran P, Opländer C, Hoffmeister D, Bibinov N, Suschek C, Wandke D, Awakowicz P. Characterization of dielectric barrier discharge (DBD) on mouse and histological evaluation of the plasma-treated tissue. Plasma Process Polym. 2011;8:246-55.
41. de Araujo T, Valencia I, Federman DG, Kirsner RS. Managing the patient with venous ulcers. Ann Intern Med. 2003;138:326-34.
42. Valencia IC, Falabella A, Kirsner RS, Eaglstein WH. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol. 2001;44:401-21.
43. Nord M. Kosteneffektivität in der Wundbehandlung. Zentralbl Chir. 2006;131:185-8.
44. Deutsche Gesellschaft für Phlebologie. Leitlinien: guidelines detail view. Diagnosis and treatment of venous leg ulcers, registration number 037-009 [c2008; cited 2014 1 Jan; in German]. Marburg, Germany: German Association of the Scientific Medical Societies. Available at: http://www.awmf.org/leitlinien/detail/ll/037-009.html.
45. Purwins S, Herberger K, Debus ES, Rustenbach SJ, Pelzer P, Rabe E, Schäfer E, Stadler R, Augustin M. Cost-of-illness of chronic leg ulcers in Germany. Int Wound J. 2010;7:97-102.
46. Karrer S. Topische Ulkustherapie. Hautarzt. 2005;56:1165-79.
47. Robson MC. Wound infection: a failure of wound healing caused by an imbalance of bacteria. Surg Clin North Am. 1997;77:637-50.
48. Robson MC, Cooper DM, Aslam R, Gould LJ, Harding KG, Margolis DJ, Ochs DE, Serena TE, Snyder RJ, Steed DL, Thomas DR, Wiersma-Bryant L. Guidelines for the treatment of venous ulcers. Wound Rep Reg. 2006;14:649-62.
49. Edwards R, Harding KG. Bacteria and wound healing. Curr Opin Infect Dis. 2004;17:91-6.
50. Kalghatgi S, Fridman G, Fridman A, Friedman G, Clyne AM. Non-thermal dielectric barrier discharge plasma treatment of endothelial cells. Conf Proc IEEE Eng Med Biol Soc. 2008;2:3578-81.
51. Fridman G, Shereshevsky A, Jost M, Brooks A, Fridman A, Gutsol A, Vasilets V, Friedman G. Floating electrode dielectric barrier discharge plasma in air promoting apoptotic behavior in melanoma skin cancer cell lines. Plasma Chem Plasma Process. 2007;27:163-78.
52. Schneider LA, Korber A, Grabbe S, Dissemond J. Influence of pH on wound-healing: a new perspective for wound-therapy? Arch Dermatol Res. 2007;298:413-20.
53. Chen WYJ, Rogers AA. Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds. Wound Rep Reg. 2007;15:434-49.
54. Metelmann HR, von Woedtke T, Bussiahn R, Weltmann KD, Rieck M, Khalili R, Podmelle F, Waite PD. Experimental recovery of CO2-laser skin lesions by plasma stimulation. Am J Cosm Surg. 2012;29:52-6.