Thyroid axis function after in-patient treatment of acute psychosis with antipsychotics: A naturalistic study

BMC Psychiatry

Volumn 14, Issue 1, 2014, Pages

  Bunevicius, Robertas ^a   Steibliene, Vesta ^a   Prange, Arthur J ^b  

^a LITHUANIAN UNIVERSITY OF HEALTH SCIENCES   (Lithuania)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Antipsychotics; Psychosis; Thyroid stimulating hormone; Thyroxine; Treatment; Triiodothyronine

Indexed keywords

LIOTHYRONINE; NEUROLEPTIC AGENT; THYROTROPIN; THYROXINE;

ACUTE PSYCHOSIS; ADULT; AGED; ARTICLE; BRIEF PSYCHIATRIC RATING SCALE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG EFFECT; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HOSPITAL PATIENT; HUMAN; HUMAN TISSUE; HYPERTHYROXINEMIA; HYPOPHYSIS THYROID SYSTEM; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PSYCHOPHARMACOTHERAPY; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TREATMENT DURATION; TREATMENT OUTCOME; ADOLESCENT; BLOOD; DRUG EFFECTS; MIDDLE AGED; PATHOPHYSIOLOGY; PSYCHOTIC DISORDERS; THYROID FUNCTION TEST; THYROID GLAND; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIPSYCHOTIC AGENTS; FEMALE; HUMANS; INPATIENTS; MALE; MIDDLE AGED; PSYCHOTIC DISORDERS; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN; THYROXINE; TREATMENT OUTCOME; TRIIODOTHYRONINE; YOUNG ADULT;

EID: 84907924767     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/s12888-014-0279-7     Document Type: Article

References (29)

1. van Os J, Kapur S. Schizophrenia. Lancet 2009, 374:635-645. 10.1016/S0140-6736(09)60995-8, 19700006.
2. Moller HJ. Pharmacotherapy of schizophrenic patients: achievements, unsolved needs, future research necessities. Curr Pharm Biotechnol 2012, 13:1476-1489. 10.2174/138920112800784907, 22283760.
3. Bunevicius R, Prange AJ. Thyroid disease and mental disorder: cause and effects or only comorbidity?. Curr Opin Psychiatr 2012, 23:363-368. 10.1097/YCO.0b013e3283387b50.
4. Tandon R, Halbreich U. The second-generation 'atypical' antipsychotics: similar improved efficacy but different neuroendocrine side effects. Psychoneuroendocrinology 2003, 28:1-7. 10.1016/S0306-4530(02)00109-9, 12504068.
5. Sim K, Chong SA, Chan YH, Lum WM. Thyroid dysfunction in chronic schizophrenia within a state psychiatric hospital. Ann Acad Med Singapore 2002, 31:641-644. 12395653.
6. Yazici K, Yazici AE, Taneli B. Different neuroendocrine profiles of remitted and nonremitted schizophrenic patients. Pro Neuropsychopharmacol Biol Psychiatr 2002, 26:579-584. 10.1016/S0278-5846(01)00311-6.
7. Roca RP, Blackman MR, Ackerley MB, Harman SM, Gregerman RI. Thyroid hormone elevations during acute psychiatric illness: relation-ship to severity and distinction from hyperthyroidism. Endocr Res 1990, 16:415-447. 10.1080/07435809009107116, 2129342.
8. Premachandra BN, Kabir MA, Williams IK. Low T3 syndrome in psychiatric depression. J Endocrinol Invest 2006, 29:568-572. 10.1007/BF03344150, 16840838.
9. Bauer M, Goetz T, Glenn T, Whybrow PC. The thyroid-brain interaction in thyroid disorders and mood disorders. J Neuroendocrinol 2008, 20:1101-1114. 10.1111/j.1365-2826.2008.01774.x, 18673409.
10. Khemka D, Ali JA, Koch CA. Primary hypothyroidism associated with acute mania: case series and literature review. Exp Clin Endocrinol Diabetes 2011, 119:513-517. 10.1055/s-0031-1277137, 21553358.
11. Steibliene V, Mickuviene N, Prange AJ, Bunevicius R. Thyroid axis hormone concentrations in psychotic patients upon hospital admission: effects of prior drug use. Medicina (Kaunas) 2012, 48:229-234.
12. Spratt DI, Pont A, Miller MB, McDougal IR, Bayer MF, McLaughlin WT. Hyperthyroxinemia in patients with acute psychiatric disorders. Am J Med 1982, 73:41-48. 10.1016/0002-9343(82)90922-6, 6807087.
13. Chopra IJ, Solomon DH, Huang TS. Serum thyrotrophin in hospitalised psychiatric patients: evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotrophin assay. Metabolism 1990, 39:538-543. 10.1016/0026-0495(90)90014-4, 2336036.
14. Prange AJ, Loosen PT, Wilson IC, Meltzer HY, Fang VS. Behavioral and endocrine responses of schizophrenic patients to TRH (pro-tirelin). Arch Gen Psychiatry 1979, 36:1086-1093. 10.1001/archpsyc.1979.01780100056005, 112944.
15. Baumgartner A, Graf KJ, Kurten I, Meinhold H. The hypothalamic-pituitary-thyroid axis in psychiatric patients and healthy subjects: Parts 1-4. Psychiatry Res 1988, 24:271-332. 10.1016/0165-1781(88)90109-6, 3136485.
16. Rinieris P, Christodoulou GN, Souvatzoglou A, Koutras DA, Stefanis C. Free-thyroxine index in schizophrenic patients before and after neuroleptic treatment. Neuropsychobiology 1980, 6:29-33. 10.1159/000117729, 6102744.
17. Southwick S, Mason JW, Giller EL, Kosten TR. Serum thyroxine change and clinical recovery in psychiatric inpatients. Biol Psychiatry 1989, 25:67-74. 10.1016/0006-3223(89)90148-0, 2912510.
18. Baumgartner A, Pietzcker A, Gaebel W. The hypothalamic-pituitary-thyroid axis in patients with schizophrenia. Schizophr Res 2000, 44:233-243. 10.1016/S0920-9964(99)00187-5, 10962225.
19. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders. Text Revision 2000, American Psychiatric Association, Washington, Fourth.
20. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998, 59:22-33. quiz 34-57, 9881538.
21. Spitzer RL, Williams JB, Gibbon M, First MB. The Structured Clinical Interview for DSM-III-R (SCID): I. History, rationale, and description. Arch Gen Psychiatry 1992, 49:624-629. 10.1001/archpsyc.1992.01820080032005, 1637252.
22. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, Farmer A, Jablenski A, Pickens R, Regier DA. The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 1998, 45:1069-1077. 10.1001/archpsyc.1988.01800360017003.
23. Mortimer AM. Symptom rating scales and outcome in schizophrenia. Br J Psychiatry Suppl 2007, 50:s7-s14. 10.1192/bjp.191.50.s7, 18019038.
24. Kelly DL, Conley RR. Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. J Clin Psychiatry 2005, 66:80-84. 10.4088/JCP.v66n0111, 15669892.
25. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340:448-454. 10.1056/NEJM199902113400607.
26. Mayilyan KR, Weinberger DR, Sim RB. The complement system in schizophrenia. Drug News Perspect 2008, 21:200-210. 10.1358/dnp.2008.21.4.1213349, 18560619.
27. Bunevicius R. Thyroid disorders in mental patients. Curr Opin Psychiatr 2009, 22:391-395. 10.1097/YCO.0b013e328329e1ae.
28. Cooper-Kazaz R, van der Deure WM, Medici M, Visser TJ, Alkelai A, Glaser B, Peeters RP, Lerer B. Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine. J Affect Disord 2009, 116:113-116. 10.1016/j.jad.2008.10.019, 19064291.
29. Santos NC, Costa P, Ruano D, Macedo A, Soares MJ, Valente J, Pereira AT, Azevedo MH, Palha JA: Revisiting thyroid hormones in schizophrenia.J Thyroid Res 2012. Epub 2012 Mar 26.