Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: A gender difference

BMC Endocrine Disorders

Volumn 14, Issue 1, 2014, Pages

  Sárközy, Márta ^a   Fekete, Veronika ^a   Szucs, Gergo ^a   Török, Szilvia ^a   Szucs, Csilla ^c   Bárkányi, Judit ^c   Varga, Zoltán V ^a,d   Földesi, Imre ^e   Csonka, Csaba ^a,b   Kónya, Csaba ^c   Csont, Tamás ^a,b   Ferdinandy, Péter ^b,d  

^a UNIVERSITY OF SZEGED   (Hungary)

^b PHARMAHUNGARY GROUP   (Hungary)

^c Béres Pharmaceuticals Ltd   (Hungary)

^d SEMMELWEIS UNIVERSITY   (Hungary)

^e UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Diabetes; Gender difference; Minerals; Multivitamin; Prevention; Streptozotocin; Trace elements

Indexed keywords

ANTIOXIDANT; HEMOGLOBIN A1C; MINERAL; TRACE ELEMENT; VITAMIN; GLUCOSE BLOOD LEVEL; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; MALE; NEWBORN; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; RAT; SEX DIFFERENCE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANALYSIS; ANIMAL; BLOOD; DIABETES MELLITUS, EXPERIMENTAL; DIET SUPPLEMENTATION; GLUCOSE TOLERANCE TEST; METABOLISM; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; MINERALS; RATS; RATS, WISTAR; SEX FACTORS; TRACE ELEMENTS; VITAMINS;

EID: 84907915233     PISSN: None     EISSN: 14726823     Source Type: Journal    
DOI: 10.1186/1472-6823-14-72     Document Type: Article

References (50)

1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787. 10.1038/414782a, 11742409.
2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053. 10.2337/diacare.27.5.1047, 15111519.
3. Astrup A, Finer N. Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'?. Obes Rev 2000, 1:57-59. 10.1046/j.1467-789x.2000.00013.x, 12119987.
4. Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011, 378:31-40. 10.1016/S0140-6736(11)60679-X, 21705069.
5. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011, 94:311-312. 10.1016/j.diabres.2011.10.029, 22079683.
6. Farvid MS, Siassi F, Jalali M, Hosseini M, Saadat N. Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes. Diabetes Care 2005, 28:2458-2464. 10.2337/diacare.28.10.2458, 16186280.
7. Kohda Y, Shirakawa H, Yamane K, Otsuka K, Kono T, Terasaki F, Tanaka T. Prevention of incipient diabetic cardiomyopathy by high-dose thiamine. J Toxicol Sci 2008, 33:459-472. 10.2131/jts.33.459, 18827445.
8. Crinó A, Schiaffini R, Ciampalini P, Suraci MC, Manfrini S, Visalli N, Matteoli MC, Patera P, Buzzetti R, Guglielmi C, Spera S, Costanza F, Fioriti E, Pitocco D, Pozzilli P, IMDIAB Group A two year observational study of nicotinamide and intensive insulin therapy in patients with recent onset type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2005, 18:749-754. IMDIAB Group.
9. Chen H, Karne RJ, Hall G, Campia U, Panza JA, Cannon RO, Wang Y, Katz A, Levine M, Quon MJ. High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance. Am J Physiol Heart Circ Physiol 2006, 290:H137-H145.
10. Hirooka Y, Eshima K, Setoguchi S, Kishi T, Egashira K, Takeshita A. Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels. Hypertens Res 2003, 26:953-959. 10.1291/hypres.26.953, 14717337.
11. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, vehicle-controlled trial. Br J Nutr 2010, 103:549-555. 10.1017/S0007114509992017, 19781131.
12. Upritchard JE, Sutherland WH, Mann JI. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000, 23:733-738. 10.2337/diacare.23.6.733, 10840987.
13. Zemel MB, Zemel PC, Bryg RJ, Sowers JR. Dietary calcium induces regression of left ventricular hypertrophy in hypertensive non-insulin-dependent diabetic blacks. Am J Hypertens 1990, 3:458-463. 10.1093/ajh/3.6.458, 2142428.
14. Guerrero-Romero F, Rodriguez-Moran M. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, vehicle-controlled clinical trial. J Hum Hypertens 2009, 23:245-251. 10.1038/jhh.2008.129, 19020533.
15. Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C, Malarkey W. Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro. Am J Clin Nutr 1997, 66:639-642.
16. Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng J. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997, 46:1786-1791. 10.2337/diab.46.11.1786, 9356027.
17. Li K, Kaaks R, Linseisen J, Rohrmann S. Vitamin/mineral supplementation and cancer, cardiovascular, and all-cause mortality in a German prospective cohort EPIC-Heidelberg. Eur J Nutr 2012, 51:407-413. 10.1007/s00394-011-0224-1, 21779961.
18. Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, Betz JM, Sempos CT, Picciano MF. Dietary supplement use in the United States, 2003-2006. J Nutr 2011, 141:261-266. 10.3945/jn.110.133025, 3021445, 21178089.
19. Bailey RL, Fulgoni VL, Keast DR, Dwyer JT. Examination of vitamin intakes among US adults by dietary supplement use. J Acad Nutr Diet 2012, 112:657-663. 10.1016/j.jand.2012.01.026, 3593649, 22709770.
20. Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MF. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000. Am J Epidemiol 2004, 160:339-344. 10.1093/aje/kwh207, 15286019.
21. Beitz R, Mensink GB, Fischer B, Thamm M. Vitamins-dietary intake and intake from dietary supplements in Germany. Eur J Clin Nutr 2002, 56:539-545. 10.1038/sj.ejcn.1601346, 12032654.
22. Sárközy M, Zvara A, Gyémánt N, Fekete V, Kocsis GF, Pipis J, Szűcs G, Csonka C, Puskás LG, Ferdinandy P, Csont T. Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats. Cardiovasc Diabetol 2013, 12:16. 10.1186/1475-2840-12-16, 3599923, 23320804.
23. Kocsis GF, Sárközy M, Bencsik P, Pipicz M, Varga ZV, Pálóczi J, Csonka C, Ferdinandy P, Csont T. Preconditioning protects the heart in a prolonged uremic condition. Am J Physiol Heart Circ Physiol 2012, 303:H1229-H1236. 10.1152/ajpheart.00379.2012, 22982778.
24. Akiyama S, Katsumata S-I, Suzuki K, Ishimi Y, Jian W, Uehara M. Dietary Hesperidin Exerts Hypoglycemic and Hypolipidemic Effects in Streptozotocin-Induced Marginal Type 1 Diabetic Rats. J Clin Biochem Nutr 2010, 46:87-92. 2803138, 20104270.
25. Wang L, Duan G, Lu Y, Pang S, Huang X, Jiang Q, Dang N. The effect of Simvastatin on glucose Homeostasis in Streptozotocin induced type 2 diabetic rats. J Diabetes Res 2013, 2013:274986. 3647597, 23671864.
26. Franconi F, Seghieri G, Canu S, Straface E, Campesi I, Malorni W. Are the available experimental models of type 2 diabetes appropriate for a gender perspective?. Pharmacol Res 2008, 57:6-18. 10.1016/j.phrs.2007.11.007, 18221886.
27. Portha B, Kergoat M. Dynamics of glucose-induced insulin release during the spontaneous remission of streptozocin diabetes induced in the newborn rat. Diabetes 1985, 34:574-579. 10.2337/diab.34.6.574, 3891470.
28. Bonner-Weir S, Trent DF, Zmachinski CJ, Clore ET, Weir GC. Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone. Metabolism 1981, 30:914-918. 10.1016/0026-0495(81)90071-8, 6115303.
29. Liang XD, Guo YY, Sun M, Ding Y, Wang N, Yuan L, De W. Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells. World J Gastroenterol 2011, 17:2812-2820. 3120940, 21734788.
30. Ye DZ, Tai MH, Linning KD, Szabo C, Olson LK. MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells. Diabetes 2006, 55:742-750. 10.2337/diabetes.55.03.06.db05-0653, 16505238.
31. Yonemura Y, Takashima T, Miwa K, Miyazaki I, Yamamoto H, Okamoto H. Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors: evidence of islet B-cell regeneration. Diabetes 1984, 33:401-404. 10.2337/diab.33.4.401, 6323238.
32. Vague P, Vialettes B, Lassman-Vague V, Vallo J. Nicotinamide may extend remission phase in insulin-dependent diabetes. Lancet 1987, 1:619-620.
33. Manna R, Migliore A, Martin LS, Ferrara E, Ponte E, Marietti G, Scuderi F, Cristiano G, Ghirlanda G, Gambassi G. Nicotinamide treatment in subjects at high risk of developing IDDM improves insulin secretion. Br J Clin Pract 1992, 46:177-179.
34. Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med 1999, 5:314-319. 10.1038/6535, 10086388.
35. Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaaire-Buys D, Novelli M, Ribes G. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 1998, 47:224-229. 10.2337/diab.47.2.224, 9519717.
36. Kishore A, Nampurath GK, Mathew SP, Zachariah RT, Potu BK, Rao MS, Valiathan M, Chamallamudi MR. Antidiabetic effect through islet cell protection in streptozotocin diabetes: a preliminary assessment of two thiazolidin-4-ones in Swiss albino mice. Chem Biol Interact 2009, 177:242-246. 10.1016/j.cbi.2008.10.032, 19038238.
37. Pittas AG, Dawson-Hughes BJ. Vitamin D and diabetes. Steroid Biochem Mol Biol 2010, 121:425-429.
38. Herchuelz A, Nguidjoe E, Jiang L, Pachera N. β-Cell preservation and regeneration in diabetes by modulation of β-cell Ca2+ homeostasis. Diabetes Obes Metab 2012, 14(3):136-142.
39. European Commission Health and Consumer Protection Directorate-General, Directorate E - Safety of the food chain Orientation paper on the setting of maximum and minimum amounts for vitamins and minerals in foodstuffs. E4 - Food law, nutrition and labelling 2007. http://www.liberterre.fr/liberterres/codex/z-pdf-codex/ec_paper_july2007.pdf, European Commission Health and Consumer Protection Directorate-General, Directorate E - Safety of the food chain.
40. Rabbani N, Alam SS, Riaz S, Larkin JR, Akhtar MW, Shafi T, Thornalley PJ. High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind vehicle-controlled pilot study. Diabetologia 2009, 52:208-212. 10.1007/s00125-008-1224-4, 19057893.
41. Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med 2008, 25:320-325. 10.1111/j.1464-5491.2007.02360.x, 18279409.
42. Pikilidou MI, Lasaridis AN, Sarafidis PA, Befani CD, Koliakos GG, Tziolas IM, Kazakos KA, Yovos JG, Nilsson PM. Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium-hydrogen exchange in hypertensive patients with Type 2 diabetes. Diabet Med 2009, 26:211-219. 10.1111/j.1464-5491.2009.02673.x, 19317814.
43. Rodriguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003, 26:1147-1152. 10.2337/diacare.26.4.1147, 12663588.
44. De Leeuw I, Engelen W, De Block C, Van Gaal L. Long term magnesium supplementation influences favourably the natural evolution of neuropathy in Mg-depleted type 1 diabetic patients T1dm. Magnes Res 2004, 17:109-114.
45. Faure P, Benhamou PY, Perard A, Halimi S, Roussel AM. Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur J Clin Nutr 1995, 49:282-288.
46. Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 1994, 17:1449-1452. 10.2337/diacare.17.12.1449, 7882815.
47. Farvid MS, Jalali M, Siassi F, Saadat N, Hosseini M. The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. Diabetes Res Clin Pract 2004, 65:21-28. 10.1016/j.diabres.2003.11.009, 15163474.
48. Crinò A, Schiaffini R, Manfrini S, Mesturino C, Visalli N, Beretta Anguissola G, Suraci C, Pitocco D, Spera S, Corbi S, Matteoli MC, Patera IP, Manca Bitti ML, Bizzarri C, Pozzilli P, IMDIAB group A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes IMDIAB IX. Eur J Endocrinol 2004, 150:719-724. 10.1530/eje.0.1500719, 15132730, IMDIAB group.
49. Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR. Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a vehicle-controlled, double-blind randomized clinical trial. J Cardiometab Syndr 2007, 2:91-97. 10.1111/j.1559-4564.2007.06366.x, 17684468.
50. Gunasekara P, Hettiarachchi M, Liyanage C, Lekamwasam S. Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. Diabetes Metab Syndr Obes 2011, 4:53-60. 3064411, 21448322.