Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand-receptor binding and therefore impairs cancer cell proliferation

Biochemical and Biophysical Research Communications

Volumn 452, Issue 4, 2014, Pages 1028-1033

  Wang, Feng ^a,b   Yang, Yong ^b,c  

^a TONGJI UNIVERSITY   (China)

^b HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cancer therapy; Insulin receptor signaling; Quercetin; Single molecule force measurement; Single molecule imaging

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR; PROTEIN KINASE B; QUERCETIN; ANTIOXIDANT; INSULIN;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL MEMBRANE; CELL PROLIFERATION; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN LOCALIZATION; ANIMAL; DRUG EFFECTS; FEMALE; METABOLISM; MOUSE; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; INSULIN; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; QUERCETIN; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84907884386     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.039     Document Type: Article

References (24)

1. J. Nakae, Y. Kido, and D. Accili Distinct and overlapping functions of insulin and IGF-I receptors Endocr. Rev. 22 2001 818 835
2. S.D. Narasimhan, K. Yen, and H.A. Tissenbaum Converging pathways in lifespan regulation Curr. Biol. 19 2009 R657 R666
3. K. Siddle Signalling by insulin and IGF receptors: supporting acts and new players J. Mol. Endocrinol. 47 2011 R1 R10
4. A. Belfiore, F. Frasca, G. Pandini, L. Sciacca, and R. Vigneri Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease Endocr. Rev. 30 2009 586 623
5. K.D. Burroughs, S.E. Dunn, J.C. Barrett, and J.A. Taylor Insulin-like growth factor-I: a key regulator of human cancer risk? J. Natl. Cancer Inst. 91 1999 579 581
6. M. Pollak Insulin and insulin-like growth factor signalling in neoplasia Nat. Rev. Cancer 8 2008 915 928
7. V.N. Anisimov Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention Exp. Gerontol. 38 2003 1041 1049
8. K. Baer, H. Al-Hasani, S. Parvaresch, T. Corona, A. Rufer, V. Nolle, E. Bergschneider, and H.W. Klein Dimerization-induced activation of soluble insulin/IGF-1 receptor kinases: an alternative mechanism of activation Biochemistry 40 2001 14268 14278
9. V.V. Kiselyov, S. Versteyhe, L. Gauguin, and P. De Meyts Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation Mol. Syst. Biol. 5 2009 243
10. C.W. Ward, and M.C. Lawrence Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor BioEssays 31 2009 422 434
11. M. Nomura, T. Takahashi, N. Nagata, K. Tsutsumi, S. Kobayashi, T. Akiba, K. Yokogawa, S. Moritani, and K. Miyamoto Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells Biol. Pharm. Bull. 31 2008 1403 1409
12. X.S. Xie, and J.K. Trautman Optical studies of single molecules at room temperature Annu. Rev. Phys. Chem. 49 1998 441 480
13. P.A. Hoyne, L.J. Cosgrove, N.M. McKern, J.D. Bentley, N. Ivancic, T.C. Elleman, and C.W. Ward High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper FEBS Lett. 479 2000 15 18
14. Y. Yang, J. Wolfram, X. Fang, H. Shen, and M. Ferrari Polyarginine induces an antitumor immune response through binding to toll-like receptor 4 Small 10 2014 1250 1254
15. Y. Yang, J. Wolfram, J. Shen, Y. Zhao, X. Fang, H. Shen, and M. Ferrari Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane FEBS Lett. 587 2013 3912 3920
16. M.H. Ulbrich, and E.Y. Isacoff Subunit counting in membrane-bound proteins Nat. Methods 4 2007 319 321
17. Y. Yang, J. Wolfram, H. Shen, X. Fang, and M. Ferrari Hesperetin: an inhibitor of the transforming growth factor-beta (TGF-beta) signaling pathway Eur. J. Med. Chem. 58 2012 390 395
18. F. Wang, and Y. Yang Suppression of the xCT-CD44v antiporter system sensitizes triple-negative breast cancer cells to doxorubicin Breast Cancer Res. Treat. 2014
19. J. Yu, Q. Wang, X. Shi, X. Ma, H. Yang, Y.G. Chen, and X. Fang Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cells J. Phys. Chem. B 111 2007 13619 13625
20. N.M. McKern, M.C. Lawrence, V.A. Streltsov, M.Z. Lou, T.E. Adams, G.O. Lovrecz, T.C. Elleman, K.M. Richards, J.D. Bentley, P.A. Pilling, P.A. Hoyne, K.A. Cartledge, T.M. Pham, J.L. Lewis, S.E. Sankovich, V. Stoichevska, E. Da Silva, C.P. Robinson, M.J. Frenkel, L.G. Sparrow, R.T. Fernley, V.C. Epa, and C.W. Ward Structure of the insulin receptor ectodomain reveals a folded-over conformation Nature 443 2006 218 221
21. G. Sweeney, R.R. Garg, R.B. Ceddia, D. Li, M. Ishiki, R. Somwar, L.J. Foster, P.O. Neilsen, G.D. Prestwich, A. Rudich, and A. Klip Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake J. Biol. Chem. 279 2004 32233 32242
22. A. Singh, A. Purohit, H.A. Hejaz, B.V. Potter, and M.J. Reed Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate Mol. Cell. Endocrinol. 160 2000 61 66
23. M. Okumura, M. Yamamoto, H. Sakuma, T. Kojima, T. Maruyama, M. Jamali, D.R. Cooper, and K. Yasuda Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression Biochim. Biophys. Acta 1592 2002 107 116
24. A.W. Harmon, and Y.M. Patel Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: a mechanism for impaired cellular proliferation Breast Cancer Res. Treat. 85 2004 103 110