6-Hydroxybenzothiophene ketones: potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) owing to favorable molecule geometry and conformational preorganization

ChemMedChem

Volumn 9, Issue 10, 2014, Pages 2294-2308

  Miralinaghi, Parisa ^a   Schmitt, Christian ^a   Hartmann, Rolf W ^a   Frotscher, Martin ^a   Engel, Matthias ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

17 hydroxysteroid dehydrogenase 1; antiestrogen agents; benzofurans; benzothiophenes; breast cancer; steroids

Indexed keywords

3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; ENZYME INHIBITOR; HYDROXYSTEROID DEHYDROGENASE; KETONE;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; HUMAN;

17-HYDROXYSTEROID DEHYDROGENASES; ENZYME INHIBITORS; HUMANS; KETONES; MOLECULAR CONFORMATION;

EID: 84907876281     PISSN: None     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402050     Document Type: Article

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