Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

ChemMedChem

Volumn 9, Issue 10, 2014, Pages 2360-2373

  Sundriyal, Sandeep ^a   Malmquist, Nicholas A ^a   Caron, Joachim ^a   Blundell, Scott ^a   Liu, Feng ^a   Chen, Xin ^a   Srimongkolpithak, Nitipol ^a   Jin, Jian ^a   Charman, Susan A ^a   Scherf, Artur ^a   Fuchter, Matthew J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

diaminoquinazolines; drug design; histone methyltransferase; malaria; structure activity relationships

Indexed keywords

ANTIMALARIAL AGENT; HISTONE LYSINE METHYLTRANSFERASE; QUINAZOLINE DERIVATIVE;

ANIMAL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; HISTONE-LYSINE N-METHYLTRANSFERASE; PLASMODIUM FALCIPARUM; QUINAZOLINES;

EID: 84907865257     PISSN: None     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402098     Document Type: Article

References (0)