A capsaicin (8%) patch in the treatment of severe persistent inguinal postherniorrhaphy pain: A randomized, double-blind, placebo-controlled trial

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Bischoff, Joakim M ^a   Ringsted, Thomas K ^a   Petersen, Marian ^a   Sommer, Claudia ^b   Üçeyler, Nurcan ^b   Werner, Mads U ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; PLACEBO;

ADULT; ANALGESIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; INGUINAL POSTHERNIORRHAPHY PAIN; INTRAEPIDERMAL NERVE FIBER DENSITY; MALE; NERVOUS SYSTEM PARAMETERS; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PAIN INTENSITY; POSTOPERATIVE PAIN; PUNCH BIOPSY; RANDOMIZED CONTROLLED TRIAL; SKIN BIOPSY; SKIN MANIFESTATION; SLEEP QUALITY; TRANSDERMAL PATCH; AGED; CLINICAL TRIAL; COMPLICATION; INGUINAL HERNIA; INNERVATION; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PROCEDURES; QUESTIONNAIRE; RISK FACTOR; SKIN;

ADULT; AGED; CAPSAICIN; FEMALE; HERNIA, INGUINAL; HUMANS; MALE; MIDDLE AGED; PAIN; PAIN MANAGEMENT; PAIN MEASUREMENT; QUESTIONNAIRES; RISK FACTORS; SKIN; TRANSDERMAL PATCH;

EID: 84907858066     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109144     Document Type: Article

References (31)

1. Rutkow IM (2003) Demographic and socioeconomic aspects of hernia repair in the United States in 2003. Surg Clin North Am 83:1045-10vi. S0039-6109 (03) 00132-4 [pii]; 10.1016/S0039-6109 (03) 00132-4 [doi].
2. Franneby U, Sandblom G, Nordin P, Nyren O, Gunnarsson U (2006) Risk factors for long-term pain after hernia surgery. Ann Surg 244:212-219.
3. Kalliomaki ML, Meyerson J, Gunnarsson U, Gordh T, Sandblom G (2008) Long-term pain after inguinal hernia repair in a population-based cohort; risk factors and interference with daily activities. Eur J Pain 12:214-225.
4. Chen DC, Hiatt JR, Amid PK (2013) Operative management of refractory neuropathic inguinodynia by a laparoscopic retroperitoneal approach. JAMA Surg 148:962-967. 1722800 [pii]; 10.1001/jamasurg.2013.3189 [doi].
5. Bischoff JM, Enghuus C, Werner MU, Kehlet H (2013) Long-term follow-up after mesh removal and selective neurectomy for persistent inguinal post-herniorrhaphy pain. Hernia 17:339-345. 10.1007/s10029-013-1073-z [doi].
6. Derry S, Sven-Rice A, Cole P, Tan T, Moore RA (2013) Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2: CD007393. 10.1002/14651858. CD007393.pub3 [doi].
7. Backonja M, Wallace MS, Blonsky ER, Cutler BJ, Malan P Jr, et al. (2008) NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol 7:1106-1112. S1474-4422 (08) 70228-X [pii]; 10.1016/S1474-4422 (08) 70228-X [doi].
8. Irving GA, Backonja MM, Dunteman E, Blonsky ER, Vanhove GF, et al. (2011) A multicenter, randomized, double-blind, controlled study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. Pain Med 12:99-109. 10.1111/j.1526-4637.2010.01004.x [doi].
9. Simpson DM, Brown S, Tobias J (2008) Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy. Neurology 70:2305-2313. 70/24/2305 [pii]; 10.1212/01.wnl.0000314647.35825.9c [doi].
10. Webster LR, Malan TP, Tuchman MM, Mollen MD, Tobias JK, et al. (2010) A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. J Pain 11:972-982. S1526-5900 (10) 00296-8 [pii]; 10.1016/j.jpain. 2010.01.270 [doi].
11. Ringkamp M, Raja SN, Campbell JN, Meyer RA (2013) Peripheral mechanisms of cutaneous nociception. In: McMahon SB, Koltzenburg M, Tracey I, Turk DC, editors. Wall and Melzack's textbook of pain. Elsevier Saunders. pp. 1-30.
12. Anand P, Bley K (2011) Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth 107:490-502. aer260 [pii]; 10.1093/bja/aer260 [doi].
13. Treede RD, Wagner T, Kern KU, Husstedt IW, Arendt G, et al. (2013) Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. Curr Med Res Opin 29:527-538. 10.1185/03007995.2013.781019 [doi].
14. Maihofner C, Heskamp ML (2013) Prospective, non-interventional study on the tolerability and analgesic effectiveness over 12 weeks after a single application of capsaicin 8% cutaneous patch in 1044 patients with peripheral neuropathic pain: first results of the QUEPP study. Curr Med Res Opin 29:673-683. 10.1185/03007995.2013.792246 [doi].
15. Aasvang EK, Hansen JB, Malmstrom J, Asmussen T, Gennevois D, et al. (2008) The effect of wound instillation of a novel purified capsaicin formulation on postherniotomy pain: a double-blind, randomized, placebo-controlled study. Anesth Analg 107:282-291.
16. Malmberg AB, Mizisin AP, Calcutt NA, Von ST, Robbins WR, et al. (2004) Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain 111:360-367. 10.1016/j.pain. 2004.07.017 [doi]; S0304-3959 (04) 00344-6 [pii].
17. Kennedy WR, Vanhove GF, Lu SP, Tobias J, Bley KR, et al. (2010) A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers. J Pain 11:579-587.
18. Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361-370.
19. Sullivan M J L, Bishop SR, Kivik J (1995) The pain catastrophizing scale: development and validation. Psych Assess 7:524-532.
20. Vernon MK, Brandenburg NA, Alvir JM, Griesing T, Revicki DA (2008) Reliability, validity, and responsiveness of the daily sleep interference scale among diabetic peripheral neuropathy and postherpetic neuralgia patients. J Pain Symptom Manage 36:54-68.
21. Bennett MI, Smith BH, Torrance N, Potter J (2005) The S-LANSS score for identifying pain of predominantly neuropathic origin: validation for use in clinical and postal research. J Pain 6:149-158.
22. Bischoff JM, Koscielniak-Nielsen ZJ, Kehlet H, Werner MU (2012) Ultrasound-guided ilioinguinal/iliohypogastric nerve blocks for persistent inguinal post-herniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial. Anesth Analg 114:1323-1329. ANE.0b013e31824d6168 [pii]; 10.1213/ANE.0b013e31824d6168 [doi].
23. Bischoff JM, Petersen M, Uceyler N, Sommer C, Kehlet H, et al. (2013) Lidocaine Patch (5%) in Treatment of Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-blind, Placebo-controlled, Crossover Trial. Anesthesiology 119:1444-1452. 10.1097/ALN.0b013e3182a2a243 [doi].
24. Torvin MA, Winther BF, Feldt-Rasmussen U, Rasmussen A, Hasholt L, et al. (2009) Functional and structural nerve fiber findings in heterozygote patients with Fabry disease. Pain 145:237-245.
25. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, et al. (2010) CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 340:c869.
26. Kehlet H, Jensen TS, Woolf CJ (2006) Persistent postsurgical pain: risk factors and prevention. Lancet 367:1618-1625.
27. Knolle E, Zadrazil M, Kovacs GG, Medwed S, Scharbert G, et al. (2013) Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study. Pain 154:2729-2736. S0304-3959 (13) 00437-5 [pii]; 10.1016/j.pain. 2013.08.001 [doi].
28. Rage M, Van AN, Facer P, Shenoy R, Knaapen MW, et al. (2010) The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers. Clin Neurophysiol 121:1256-1266. S1388-2457 (10) 00263-4 [pii]; 10.1016/j.clinph.2010.02.159 [doi].
29. Webster LR, Tark M, Rauck R, Tobias JK, Vanhove GF (2010) Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia. BMC Neurol 10:92. 1471-2377-10-92 [pii]; 10.1186/1471-2377-10-92 [doi].
30. Mikkelsen T, Werner MU, Lassen B, Kehlet H (2004) Pain and sensory dysfunction 6 to 12 months after inguinal herniotomy. Anesth Analg 99:146-151.
31. Aasvang EK, Brandsborg B, Jensen TS, Kehlet H (2010) Heterogeneous sensory processing in persistent postherniotomy pain. Pain 150:237-242.