Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients

Atherosclerosis

Volumn 237, Issue 1, 2014, Pages 177-182

  Grufman, Helena ^a   Schiopu, Alexandru ^a,b   Edsfeldt, Andreas ^a,b   Björkbacka, Harry ^a   Nitulescu, Mihaela ^a   Nilsson, Marie ^a,b   Persson, Ana ^a,b   Nilsson, Jan ^a   Gonçalves, Isabel ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Aging; Atherosclerosis; Carotid stenosis; Cytokine; Inflammation

Indexed keywords

CD40 LIGAND; COLLAGEN; CREATININE; CYTOKINE; ELASTIN; FRACTALKINE; GAMMA INTERFERON; GROWTH FACTOR; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1BETA; LIPID; LOW DENSITY LIPOPROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PLATELET DERIVED GROWTH FACTOR AB; PLATELET DERIVED GROWTH FACTOR BB; RANTES; SCLEROPROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; ARTICLE; CAROTID ARTERY OBSTRUCTION; CAROTID ATHEROSCLEROSIS; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; ENDARTERECTOMY; FEMALE; GERIATRIC PATIENT; GROUPS BY AGE; HOMOGENATE; HUMAN; HUMAN TISSUE; INFLAMMATION; LIPID STORAGE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; SMOOTH MUSCLE FIBER; TISSUE REPAIR; VERY ELDERLY; AGE; AGING; BLOOD; CAROTID ARTERY; CAROTID ENDARTERECTOMY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PLAQUE, ATHEROSCLEROTIC;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CAROTID ARTERIES; CAROTID STENOSIS; COLLAGEN; CYTOKINES; ELASTIN; ENDARTERECTOMY, CAROTID; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; LIPIDS; MACROPHAGES; MALE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC;

EID: 84907726913     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.08.042     Document Type: Article

References (25)

1. Barnett H.J., Taylor D.W., Eliasziw M., et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American symptomatic carotid endarterectomy trial collaborators. NEngl J Med 1998, 339:1415-1425.
2. Halliday A., Mansfield A., Marro J., et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004, 363:1491-1502.
3. Naghavi M., Libby P., Falk E., et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 2003, 108:1664-1672.
4. Redgrave J.N., Lovett J.K., Rothwell P.M. Histological features of symptomatic carotid plaques in relation to age and smoking: the oxford plaque study. Stroke 2010, 41:2288-2294.
5. van Lammeren G.W., Reichmann B.L., Moll F.L., et al. Atherosclerotic plaque vulnerability as an explanation for the increased risk of stroke in elderly undergoing carotid artery stenting. Stroke 2011, 42:2550-2555.
6. van Oostrom O., Velema E., Schoneveld A.H., et al. Age-related changes in plaque composition: a study in patients suffering from carotid artery stenosis. Cardiovasc Pathol 2005, 14:126-134.
7. Peeters W., Hellings W.E., de Kleijn D.P., et al. Carotid atherosclerotic plaques stabilize after stroke: insights into the natural process of atherosclerotic plaque stabilization. Arterioscler Thromb Vasc Biol 2009, 29:128-133.
8. Goncalves I., Moses J., Dias N., et al. Changes related to age and cerebrovascular symptoms in the extracellular matrix of human carotid plaques. Stroke 2003, 34:616-622.
9. Edsfeldt A., Nitulescu M., Grufman H., et al. Soluble urokinase plasminogen activator receptor is associated with inflammation in the vulnerable human atherosclerotic plaque. Stroke 2012, 43:3305-3312.
10. Vedre A., Pathak D.R., Crimp M., Lum C., Koochesfahani M., Abela G.S. Physical factors that trigger cholesterol crystallization leading to plaque rupture. Atherosclerosis 2009, 203:89-96.
11. Abela G.S. Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation. JClin Lipidol 2010, 4:156-164.
12. Reber A.J., Chirkova T., Kim J.H., et al. Immunosenescence and challenges of vaccination against influenza in the aging population. Aging Dis 2012, 3:68-90.
13. Desai A., Grolleau-Julius A., Yung R. Leukocyte function in the aging immune system. JLeukoc Biol 2010, 87:1001-1009.
14. Schoenborn J.R., Wilson C.B. Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 2007, 96:41-101.
15. Parameswaran N., Patial S. Tumor necrosis factor-alpha signaling in macrophages. Crit Rev Eukaryot Gene Expr 2010, 20:87-103.
16. Liu H., Jiang D. Fractalkine/CX3CR1 and atherosclerosis. Clin Chim Acta 2011, 412:1180-1186.
17. Antoniades C., Bakogiannis C., Tousoulis D., Antonopulos A.S., Stefanidis C. The CD40/CD40 ligand system: linking inflammation with atherothrombosis. JAm Coll Cardiol 2009, 54:669-677.
18. Priyanka H.P., Sharma U., Gopinath S., Sharma V., Hima L., ThyagaRajan S. Menstrual cycle and reproductive aging alters immune reactivity, NGF expression, antioxidant enzyme activities, and intracellular signaling pathways in the peripheral blood mononuclear cells of healthy women. Brain Behav Immun 2013, 32:131-143.
19. Agius E., Lacy K.E., Vukmanovic-Stejic M., et al. Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. JExp Med 2009, 206:1929-1940.
20. Montecucco F., Lenglet S., Gayet-Ageron A., et al. Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke. Stroke 2010, 41:1394-1404.
21. Verhoeven B., Hellings W.E., Moll F.L., et al. Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients. JVasc Surg 2005, 42:1075-1081.
22. Inoue M., Itoh H., Ueda M., et al. Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 1998, 98:2108-2116.
23. Halvorsen B., Otterdal K., Dahl T.B., et al. Atherosclerotic plaque stability-what determines the fate of a plaque?. Prog Cardiovasc Dis 2008, 51:183-194.
24. Engelbertsen D., Andersson L., Ljungcrantz I., et al. T-helper 2 immunity is associated with reduced risk of myocardial infarction and stroke. Arterioscler Thromb Vasc Biol 2013, 33:637-644.
25. Carr S.C., Farb A., Pearce W.H., Virmani R., Yao J.S. Activated inflammatory cells are associated with plaque rupture in carotid artery stenosis. Surgery 1997, 122:757-763. discussion 763-754.