The low frequency power of heart rate variability is neither a measure of cardiac sympathetic tone nor of baroreflex sensitivity

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 7, 2014, Pages H1005-H1012

  Martelli, Davide ^a   Silvani, Alessandro ^b   McAllen, Robin M ^a   May, Clive N ^a   Ramchandra, Rohit ^a,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Baroreceptor reflex; Heart; Heart failure; Heart rate variability; Sympathetic nervous system

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; ELECTROCARDIOGRAM; EWE; FEMALE; HEART BEAT; HEART CYCLE; HEART FAILURE; HEART INNERVATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE VARIABILITY; NONHUMAN; PRESSORECEPTOR REFLEX; QUANTITATIVE ANALYSIS; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE; ADRENERGIC SYSTEM; ANALYSIS OF VARIANCE; ANIMAL; HEART; HEART RATE; INNERVATION; PHYSIOLOGY; SHEEP;

ANALYSIS OF VARIANCE; ANIMALS; BAROREFLEX; FEMALE; HEART; HEART RATE; SHEEP; SYMPATHETIC NERVOUS SYSTEM;

EID: 84907618528     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00361.2014     Document Type: Article

References (24)

1. Berger RD, Saul JP, Cohen RJ. Transfer function analysis of autonomic regulation. I. Canine atrial rate response. Am J Physiol Heart Circ Physiol 256: H142-H152, 1989.
2. Bertram D, Barres C, Cuisinaud G, Julien C. The arterial baroreceptor reflex of the rat exhibits positive feedback properties at the frequency of Mayer waves. J Physiol 513: 251-261, 1998.
3. Brunner-La Rocca HP, Esler MD, Jennings GL, Kaye DM. Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure. Eur Heart J 22: 1136-1143, 2001.
4. Cannon WB. Organization for physiological homeostasis. Physiol Rev 9: 399-432, 1929.
5. deBoer RW, Karemaker JM, Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol Heart Circ Physiol 253: H680-H689, 1987.
6. Eckberg DL. Sympathovagal balance. A critical appraisal. Circulation 96: 3224-3232, 1997.
7. Task Force of the European Society of Cardiology, North American Society of Pacing and Electrophysiology. Heart rate variability Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17: 354-381, 1996.
8. Goldstein DS, Bentho O, Park MY, Sharabi Y. Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes. Exp Physiol 96: 1255-1261, 2011.
9. Heathers JAJ. Sympathovagal balance from heart rate variability: an obituary. Exp Physiol 97: 556, 2012.
10. Jardine DL, Charles CJ, Melton IC, May CN, Forrester MD, Frampton CM, Bennett SI, Ikram H. Continual recordings of cardiac sympathetic nerve activity in conscious sheep. Am J Physiol Heart Circ Physiol 282: H93-H99, 2002.
11. Kaye DM, Lambert GW, Lefkovits J, Morris M, Jennings G, Esler MD. Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. J Am Coll Cardiol 23: 570-578, 1994.
12. Malpas SC. Neural influences on cardiovascular variability: possibilities and pitfalls. Am J Physiol Heart Circ Physiol 282: H6-H20, 2002.
13. McKinley MJ, Weissenborn F, Mathai ML. Drinking-induced thermoregulatory panting in rehydrated sheep: influences of oropharyngeal/ esophageal signals, core temperature, and thirst satiety. Am J Physiol Regul Integr Comp Physiol 296: R1881-R1888, 2009.
14. Moak JP, Goldstein DS, Eldadah BA, Saleem A, Holmes C, Pechnik S, Sharabi Y. Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiacsympathetic innervation. Heart Rhythm 4: 1523-1529, 2007.
15. Pagani M, Lucini D, Porta A, Furlan R. Extracting autonomic information from oscillations in MSNA. J Physiol 590: 647-648, 2012.
16. Piccirillo G, Ogawa M, Song J, Chong VJ, Joung B, Han S, Magrì D, Chen LS, Lin SF, Chen PS. Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure. Heart Rhythm 6: 546-552, 2009.
17. Rahman F, Pechnik S, Gross D, Sewell L, Goldstein DS. Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation. Clin Auton Res 21: 133-141, 2011.
18. Ramchandra R, Hood SG, Denton DA, Woods RL, McKinley MJ, McAllen RM, May CN. Basis for the preferential activation of cardiac sympathetic nerve activity in heart failure. Proc Natl Acad Sci USA 106: 924-928, 2009.
19. Silvani A, Asti V, Bojic T, Ferrari V, Franzini C, Lenzi P, Grant DA, Walker AM, Zoccoli G. Sleep-dependent changes in the coupling between heart period and arterial pressure in newborn lambs. Pediatr Res 57: 108-114, 2005.
20. Silvani A, Grimaldi D, Vandi S, Barletta G, Vetrugno R, Provini F, Pierangeli G, Berteotti C, Montagna P, Zoccoli G, Cortelli P. Sleepdependent changes in the coupling between heart period and blood pressure in human subjects. Am J Physiol Regul Integr Comp Physiol 294: R1686-R1692, 2008.
21. Silvani A, Magosso E, Bastianini S, Lenzi P, Ursino M. Mathematical modeling of cardiovascular coupling: Central autonomic commands and baroreflex control. Auton Neurosci 162: 66-71, 2011.
22. Timmers HJ, Buskens FG, Wieling W, Karemaker JM, Lenders JW. Long-term effects of unilateral carotid endarterectomy on arterial baroreflex function. Clin Auton Res 14: 72-79, 2004.
23. Watson AM, Hood SG, Ramchandra R, McAllen RM, May CN. Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex. Am J Physiol Heart Circ Physiol 293: H798-H804, 2007.
24. Watson AM, Mogulkoc R, McAllen RM, May CN. Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep. Am J Physiol Regul Integr Comp Physiol 286: R1051-R1056, 2004.