HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats

Hypertension

Volumn 64, Issue 3, 2014, Pages 541-550

  Jin, Chunhua ^a   Sun, Jingping ^a   Stilphen, Carly A ^a   Smith, Susan M E ^c   Ocasio, Hiram ^a   Bermingham, Brent ^a   Darji, Sandip ^a   Guha, Avirup ^a   Patel, Roshan ^a   Geurts, Aron M ^b   Jacob, Howard J ^b   Lambert, Nevin A ^a   O'Connor, Paul M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c KENNESAW STATE UNIVERSITY   (United States)

Author keywords

Free radicals; Hypertension; Oxidative stress

Indexed keywords

CATION CHANNEL; SODIUM; SODIUM CHLORIDE; SUPEROXIDE; UNCLASSIFIED DRUG; VOLTAGE GATED CHANNEL FORMING PROTEIN; VOLTAGE GATED PROTON CHANNEL HV1; ZINC FINGER NUCLEASE;

ACIDIFICATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CELL PH; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; GENE TARGETING; INTRACELLULAR SIGNALING; KIDNEY MEDULLA; KIDNEY STRUCTURE; KIDNEY TUBULE; KIDNEY TUBULE DAMAGE; MEDULLARY THICK ASCENDING LIMB; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PREPULSE INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTON TRANSPORT; RAT; RAT MUTANT; SALT INTAKE; SODIUM CELL LEVEL; WILD TYPE;

FREE RADICALS; HYPERTENSION; OXIDATIVE STRESS;

ANIMALS; DISEASE MODELS, ANIMAL; HYDROGEN; HYDROGEN-ION CONCENTRATION; HYPERTENSION; ION CHANNELS; KIDNEY DISEASES; LOOP OF HENLE; MALE; NADP; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED DAHL; RATS, MUTANT STRAINS; REACTIVE OXYGEN SPECIES; SODIUM; SUPEROXIDES;

EID: 84907598794     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.03549     Document Type: Article

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