-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ,. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
84863504256
-
Apolipoprotein e and apolipoprotein e receptors: Normal biology and roles in Alzheimer disease
-
Holtzman DM, Herz J, Bu G,. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2: a006312.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Holtzman, D.M.1
Herz, J.2
Bu, G.3
-
3
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012; 488: 96-99.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
-
4
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
-
Karran E, Mercken M, De Strooper B,. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 2011; 10: 698-712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
5
-
-
0028055038
-
Down's syndrome: Up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination
-
Oyama F, Cairns NJ, Shimada H, et al. Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. J Neurochem 1994; 62: 1062-1066.
-
(1994)
J Neurochem
, vol.62
, pp. 1062-1066
-
-
Oyama, F.1
Cairns, N.J.2
Shimada, H.3
-
6
-
-
29444442794
-
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
-
Rovelet-Lecrux A, Hannequin D, Raux G, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006; 38: 24-26.
-
(2006)
Nat Genet
, vol.38
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
Hannequin, D.2
Raux, G.3
-
8
-
-
84860215480
-
Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature
-
Nelson PT, Alafuzoff I, Bigio EH, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 2012; 71: 362-381.
-
(2012)
J Neuropathol Exp Neurol
, vol.71
, pp. 362-381
-
-
Nelson, P.T.1
Alafuzoff, I.2
Bigio, E.H.3
-
9
-
-
84889090645
-
Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center
-
Serrano-Pozo A, Qian J, Monsell SE, et al. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol 2013; 72: 1182-1192.
-
(2013)
J Neuropathol Exp Neurol
, vol.72
, pp. 1182-1192
-
-
Serrano-Pozo, A.1
Qian, J.2
Monsell, S.E.3
-
10
-
-
84907597179
-
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
-
Karran E, Hardy J,. A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease. Ann Neurol 2014; 76: 185-205.
-
(2014)
Ann Neurol
, vol.76
, pp. 185-205
-
-
Karran, E.1
Hardy, J.2
-
11
-
-
84898728701
-
Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β
-
Toyn JH, Ahlijanian M,. Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β. Alzheimer Res Ther 2014; 6: 14.
-
(2014)
Alzheimer Res Ther
, vol.6
, pp. 14
-
-
Toyn, J.H.1
Ahlijanian, M.2
-
12
-
-
80051569682
-
Amyloid-dependent and amyloid-independent stages of Alzheimer disease
-
Hyman BT,. Amyloid-dependent and amyloid-independent stages of Alzheimer disease. Arch Neurol 2011; 68: 1062-1064.
-
(2011)
Arch Neurol
, vol.68
, pp. 1062-1064
-
-
Hyman, B.T.1
-
13
-
-
84899981521
-
Mild to moderate Alzheimer dementia with insufficient neuropathological changes
-
Serrano-Pozo A, Qian J, Monsell SE, et al. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Ann Neurol 2014; 75: 597-601.
-
(2014)
Ann Neurol
, vol.75
, pp. 597-601
-
-
Serrano-Pozo, A.1
Qian, J.2
Monsell, S.E.3
-
14
-
-
84865529158
-
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
Bateman RJ, Xiong C, Benzinger TL, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012; 367: 795-804.
-
(2012)
N Engl J Med
, vol.367
, pp. 795-804
-
-
Bateman, R.J.1
Xiong, C.2
Benzinger, T.L.3
-
15
-
-
84866122213
-
Sting of Alzheimer's failures offset by upcoming prevention trials
-
Mullard A,. Sting of Alzheimer's failures offset by upcoming prevention trials. Nat Rev Drug Discov 2012; 11: 657-660.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 657-660
-
-
Mullard, A.1
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