Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment

PLoS Neglected Tropical Diseases

Volumn 8, Issue 9, 2014, Pages

  Lamberton, Poppy H L ^a   Kabatereine, Narcis B ^b   Oguttu, David W ^b   Fenwick, Alan ^a   Webster, Joanne P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MINISTRY OF HEALTH   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; PRAZIQUANTEL; ANTHELMINTIC AGENT; PARASITE ANTIGEN;

ARTICLE; CHILD; CLINICAL EVALUATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG EFFICACY; FECES ANALYSIS; FEMALE; FOLLOW UP; HUMAN; KATO-KATZ THICK SMEAR; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NONHUMAN; PARASITE IDENTIFICATION; PARASITE PREVALENCE; POINT OF CARE CIRCULATING CATHODIC ANTIGEN TEST; PREDICTIVE VALUE; PRESCHOOL CHILD; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; URINALYSIS; ANIMAL; BLOOD; FECES; ISOLATION AND PURIFICATION; PARASITOLOGY; PATHOLOGY; URINE;

ANIMALS; ANTHELMINTICS; ANTIGENS, HELMINTH; CHILD; FECES; HUMANS; PRAZIQUANTEL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SENSITIVITY AND SPECIFICITY;

EID: 84907587231     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003139     Document Type: Article

References (55)

1. Webster JP, Molyneux D, Hotez P, Fenwick A, (2014) The contribution of mass drug administration to global health – past, present and future. Philos Trans R Soc Lond B Biol Sci 369: 1471–2970.
2. World Health Organization (2012). Accelarating work to overcome the global impact of neglected tropical diseases – A roadmap for implementation. Available: [http://whqlibdoc.who.int/hq/2012/WHO_HTM_NTD_2012.1_eng.pdf?ua=1], accessed: 26 March 2014.
3. (2012) London Declaration on Neglected Tropical Diseases. http://www.who.int/neglected_diseases/London_Declaration_NTDs.pdf?ua=1.
4. Gomes LI, Enk MJ, Rabello A, (2014) Diagnosing schistosomiasis: where are we? Rev Soc Bras Med Trop 47: 3–11.
5. Bergquist R, Johansen MV, Utzinger J, (2009) Diagnostic dilemmas in helminthology: what tools to use and when? Trends Parasitol 25: 151–156.
6. Brooker S, Kabatereine NB, Gyapong JO, Stothard JR, Utzinger J, (2009) Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa. Parasitology 136: 1707–1718.
7. Stothard JR, Chitsulo L, Kristensen TK, Utzinger J, (2009) Control of schistosomiasis in sub-Saharan Africa: progress made, new opportunities and remaining challenges. Parasitology 136: 1665–1675.
8. Utzinger J, Raso G, Brooker S, de Savigny D, Tanner M, et al. (2009) Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution. Parasitology 136: 1859–1874.
9. Utzinger J, N'Goran EK, Caffrey CR, Keiser J, (2011) From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop 120 Suppl 1: S121–137.
10. Knopp S, Stothard JR, Rollinson D, Mohammed KA, Khamis IS, et al. (2013) From morbidity control to transmission control: time to change tactics against helminths on Unguja Island, Zanzibar. Acta Trop 128: 412–422.
11. Rollinson D, Knopp S, Levitz S, Stothard JR, Tchuem Tchuente LA, et al. (2013) Time to set the agenda for schistosomiasis elimination. Acta Trop 128: 423–440.
12. Albonico M, Engels D, Savioli L, (2004) Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control. Int J Parasitol 34: 1205–1210.
13. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, et al. (2007) Control of neglected tropical diseases. N Engl J Med 357: 1018–1027.
14. Katz N, Chaves A, Pellegrino J, (1972) A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop São Paulo 14: 397–400.
15. World Health Organization (2002). Prevention and Control of Schistosomiasis and Soil-Transmitted Helminthiasis. Technical Series Report 912. Available: [http://whqlibdoc.who.int/trs/WHO_TRS_912.pdf], accessed: 15th May 2014.
16. Engels D, Sinzinkayo E, Gryseels B, (1996) Day-to-day egg count fluctuation in Schistosoma mansoni infection and its operational implications. Am J Trop Med Hyg 54: 319–324.
17. Vennervald BJ, Ouma JH, Butterworth AE, (1998) Morbidity in schistosomiasis: assessment, mechanisms and control. Parasitol Today 14: 385–390.
18. Utzinger J, Booth M, N'Goran EK, Műller I, Tanner M, et al. (2001) Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of Schistosoma mansoni before and after treatment with praziquantel. Parasitology 122: 537–544.
19. Booth M, Vounatsou P, N'Goran EK, Tanner M, Utzinger J, (2003) The influence of sampling effort and the performance of the Kato-Katz technique in diagnosing Schistosoma mansoni and hookworm co-infections in rural Côte d'Ivoire. Parasitology 127: 525–531.
20. Knopp S, Rinaldi L, Khamis IS, Stothard JR, Rollinson D, et al. (2009) A single FLOTAC is more sensitive than triplicate Kato-Katz for the diagnosis of low-intensity soil-transmitted helminth infections. Trans R Soc Trop Med Hyg 103: 347–354.
21. da Frota SM, Carneiro TR, Queiroz JA, Alencar LM, Heukelbach J, et al. (2011) Combination of Kato-Katz faecal examinations and ELISA to improve accuracy of diagnosis of intestinal schistosomiasis in a low-endemic setting in Brazil. Acta Trop 120 Suppl 1: S138–141.
22. Enk MJ, Lima AC, Drummond SC, Schall VT, Coelho PM, (2008) The effect of the number of stool samples on the observed prevalence and the infection intensity with Schistosoma mansoni among a population in an area of low transmission. Acta Trop 108: 222–228.
23. Siqueira LM, Coelho PM, Oliveira AA, Massara CL, Carneiro NF, et al. (2011) Evaluation of two coproscopic techniques for the diagnosis of schistosomiasis in a low-transmission area in the state of Minas Gerais, Brazil. Mem Inst Oswaldo Cruz 106: 844–850.
24. Lin DD, Liu JX, Liu YM, Hu F, Zhang YY, et al. (2008) Routine Kato-Katz technique underestimates the prevalence of Schistosoma japonicum: a case study in an endemic area of the People's Republic of China. Parasitol Int 57: 281–286.
25. Cesari IM, Ballen DE, Mendoza L, Matos C, (2005) Detection of Schistosoma mansoni membrane antigens by immunoblot analysis of sera of patients from low-transmission areas. Clin Diagn Lab Immunol 12: 280–286.
26. Grenfell RF, Martins W, Enk M, Almeida A, Siqueira L, et al. (2013) Schistosoma mansoni in a low-prevalence area in Brazil: the importance of additional methods for the diagnosis of hard-to-detect individual carriers by low-cost immunological assays. Mem Inst Oswaldo Cruz 108.
27. Grenfell RF, Coelho PM, Taboada D, de Mattos AC, Davis R, et al. (2014) Newly established monoclonal antibody diagnostic assays for Schistosoma mansoni direct detection in areas of low endemicity. PloS One 9: e87777.
28. Grenfell R, Harn DA, Tundup S, Da'dara A, Siqueira L, et al. (2013) New approaches with different types of circulating cathodic antigen for the diagnosis of patients with low Schistosoma mansoni load. PLoS Negl Trop Dis 7: e2054.
29. van Lieshout L, Panday UG, de Jonge N, Krijger FW, Oostburg BF, et al. (1995) Immunodiagnosis of schistosomiasis mansoni in a low endemic area in Surinam by determination of the circulating antigens CAA and CCA. Acta Trop 59: 19–29.
30. Van Dam GJ. Schistosomiasis diagnosis by circulating antigen detection: from lab-based ultimate UCP-lateral flow diagnostic to field-available point-of-care rapid test; 2012; Rio de Janeiro, Brazil.
31. van Lieshout L, Polderman AM, Deelder AM, (2000) Immunodiagnosis of schistosomiasis by determination of the circulating antigens CAA and CCA, in particular in individuals with recent or light infections. Acta Trop 77: 69–80.
32. Stothard JR, Kabatereine NB, Tukahebwa EM, Kazibwe F, Rollinson D, et al. (2006) Use of circulating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasis. Acta Trop 97: 219–228.
33. Coulibaly JT, Knopp S, N'Guessan NA, Silué KD, Fűrst T, et al. (2011) Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire. PLoS Negl Trop Dis 5: e1384.
34. Shane HL, Verani JR, Abudho B, Montgomery SP, Blackstock AJ, et al. (2011) Evaluation of urine CCA assays for detection of Schistosoma mansoni infection in Western Kenya. PLoS Negl Trop Dis 5: e951.
35. Colley DG, Binder S, Campbell C, King CH, Tchuem Tchuenté LA, et al. (2013) A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni. Am J Trop Med Hyg 88: 426–432.
36. Koukounari A, Donnelly CA, Moustaki I, Tukahebwa EM, Kabatereine NB, et al. (2013) A latent Markov modelling approach to the evaluation of circulating cathodic antigen strips for schistosomiasis diagnosis pre- and post-praziquantel treatment in Uganda. PLoS Comput Biol 9: e1003402.
37. Adriko M, Standley CJ, Tinkitina B, Tukahebwa EM, Fenwick A, et al. (2014) Evaluation of circulating cathodic antigen (CCA) urine-cassette assay as a survey tool for Schistosoma mansoni in different transmission settings within Bugiri District, Uganda. Acta Trop
38. Standley CJ, Lwambo NJS, Lange CN, Kariuki HC, Adriko M, et al. (2010) Performance of circulating cathodic antigen (CCA) urine-dipstick for rapid detection of intestinal schistosomiasis in schoolchildren from shoreline communities of Lake Victoria. Parasit Vectors 3: 7.
39. Koukounari A, Webster JP, Donnelly CA, Bray BC, Naples J, et al. (2009) Sensitivities and specificities of diagnostic tests and infection prevalence of Schistosoma haematobium estimated from data on adults in villages northwest of Accra, Ghana. Am J Trop Med Hyg 80: 435–441.
40. Ashton RA, Stewart BT, Petty N, Lado M, Finn T, et al. (2011) Accuracy of circulating cathodic antigen tests for rapid mapping of Schistosoma mansoni and S. haematobium infections in Southern Sudan. Trop Med Int Health 16: 1099–1103.
41. Coulibaly JT, N'Gbesso YK, Knopp S, N'Guessan NA, Silué KD, et al. (2013) Accuracy of urine circulating cathodic antigen test for the diagnosis of Schistosoma mansoni in preschool-aged children before and after treatment. PLoS Negl Trop Dis 7: e2109.
42. Kabatereine NB, Brooker S, Koukounari A, Kazibwe F, Tukahebwa EM, et al. (2007) Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bull World Health Organ 85: 91–99.
43. Lamberton PHL, Hogan SC, Kabatereine NB, Fenwick A, Webster JP, (2010) In vitro praziquantel test capable of detecting reduced in vivo efficacy in Schistosoma mansoni human infections. Am J Trop Med Hyg 83: 1340–1347.
44. Landis JR, Koch GG, (1977) The measurement of observer agreement for categorical data. Biometrics 33: 159–174.
45. Tchuem Tchuenté LA, Kuete Fouodo CJ, Kamwa Ngassam RI, Sumo L, Dongmo Noumedem C, et al. (2012) Evaluation of circulating cathodic antigen (CCA) urine-tests for diagnosis of Schistosoma mansoni infection in Cameroon. PLoS Negl Trop Dis 6: e1758.
46. Erko B, Medhin G, Teklehaymanot T, Degarege A, Legesse M, (2013) Evaluation of urine-circulating cathodic antigen (urine-CCA) cassette test for the detection of Schistosoma mansoni infection in areas of moderate prevalence in Ethiopia. Trop Med Int Health 18: 1029–1035.
47. De Clercq D, Sacko M, Vercruysse J, vanden Bussche V, Landoure A, et al. (1997) Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali. Acta Trop 68: 339–346.
48. Zhang Y, Koukounari A, Kabatereine N, Fleming F, Kazibwe F, et al. (2007) Parasitological impact of two-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda. BMC Med 5: 27.
49. Knopp S, Speich B, Hattendorf J, Rinaldi L, Mohammed KA, et al. (2011) Diagnostic accuracy of Kato-Katz and FLOTAC for assessing anthelmintic drug efficacy. PLoS Negl Trop Dis 5: e1036.
50. French MD, Churcher TS, Gambhir M, Fenwick A, Webster JP, et al. (2010) Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: a mathematical modelling study. PLoS Negl Trop Dis 4: e897.
51. Stete K, Krauth SJ, Coulibaly JT, Knopp S, Hattendorf J, et al. (2012) Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children. Parasit Vectors 5: 298.
52. Plaisier AP, Alley ES, Boatin BA, Van Oortmarssen GJ, Remme H, et al. (1995) Irreversible effects of ivermectin on adult parasites in onchocerciasis patients in the Onchocerciasis Control Programme in West Africa. J Infect Dis 172: 204–210.
53. Kim JS, Oh DS, Ahn KS, Shin SS, (2012) Effects of kimchi extract and temperature on embryostasis of Ascaris suum eggs. Korean J Parasitol 50: 83–87.
54. Criscione CD, Poulin R, Blouin MS, (2005) Molecular ecology of parasites: elucidating ecological and microevolutionary processes. Mol Ecol 14: 2247–2257.
55. Gower CM, Gabrielli AF, Sacko M, Dembele R, Golan R, et al. (2011) Population genetics of Schistosoma haematobium: development of novel microsatellite markers and their application to schistosomiasis control in Mali. Parasitology 138: 978–994.