Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's disease

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Fransen, Karin ^a   Franzén, Petra ^a   Magnuson, Anders ^b   Elmabsout, Ali Ateia ^a   Nyhlin, Nils ^b   Wickbom, Anna ^b   Curman, Bengt ^b   Törkvist, Leif ^c,d   D'Amato, Mauro ^d   Bohr, Johan ^a,b   Tysk, Curt ^a,b   Sirsjö, Allan ^a   Halfvarson, Jonas ^a,b  

^a ÖREBRO UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; CYTOCHROME P450; RETINOIC ACID 4-HYDROXYLASE;

ADULT; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYP26B1 GENE; ENZYMATIC DEGRADATION; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS; ULCEROGENESIS; ALLELE; CASE CONTROL STUDY; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; METABOLISM;

ADULT; ALLELES; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; TRETINOIN;

EID: 84907505415     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072739     Document Type: Article

References (27)

1. Crockett SD, Porter CQ, Martin CF, Sandler RS, Kappelman MD (2010) Isotretinoin use and the risk of inflammatory bowel disease: a case-control study. Am J Gastroenterol 105: 1986-1993.
2. Mora JR, Iwata M, von Andrian UH (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8: 685-698.
3. Blomhoff R, Blomhoff HK (2006) Overview of retinoid metabolism and function. J Neurobiol 66: 606-630.
4. Thatcher JE, Isoherranen N (2009) The role of CYP26 enzymes in retinoic acid clearance. Expert Opin Drug Metab Toxicol 5: 875-876.
5. Kastner P, Mark M, Ghyselinck N, Krezel W Dupé V, et al. (1997) Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development 124: 313-326.
6. Petkovich M, Brand NJ, Krust A, Chambon P (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330: 444-450.
7. Bastien J, Rochette-Egly C (2004) Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 328: 1-16.
8. Lalevee S, Anno YN, Chatagnon AA, Samarut E, Poch O, et al. (2011) Genome-wide in silico identification of new conserved and functional retinoic acid receptors response elements (direct repeats separated by 5BP). J Biol Chem 23: 33322-33334.
9. White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, et al. (1997) cDNA cloning of human retinoic acid metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem 272: 18538-18541.
10. White JA, Ramshaw H, Taimi M, Strangle W, Zhang A, et al. (2000) Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. Proc Natl Acad Sci USA 97: 6403-6408.
11. Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, et al. (2004) A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and Alltrans Isomers of retinoic acid. J Biol Chem 279: 77-85.
12. Takeuchi H, Yokota A, Ohoka Y, Iwata M (2011) Cyp26B1 regulates retinoic acid-dependent signals in T-cells and its expression is inhibited by transforming growth factor-b. PLoSone 6: 1-8.
13. Kang SG, Wang C, Matsumoto S, Kim CH (2009) High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation. Gastroenterology 137: 1391-1402.
14. Krivospitskaya O, Elmabsout AA, Sundman E, Söderström LA, Ovchinnikova O, et al. (2012) A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis. Mol Med 18: 712-718.
15. Lennard-Jones JE (1989) Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170: 2-6, 16-19.
16. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, et al. (2005) Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 19 Suppl A: 5-36.
17. Shale M, Kaplan GG, Panaccione R, Ghosh S (2009) Isotretinoin and intestinal inflammation: what gastroenterologists need to know. Gut 58: 737-741.
18. Reddy D, Siegel CA, Sands BE, Kane S (2006) Possible association between isotretinoin and inflammatory bowel disease. Am J Gastroenterol 101: 1569-1573.
19. Bernstein CN, Nugent Z, Longobardi T, Blanchard JF (2009) Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol 104: 2774-2778.
20. Reifen R, Nur T, Ghebermeskel K, Zaiger G, Urizky R, et al. (2002) Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of Nuclear Factor-kB and collagen formation. J Nutr 132: 2743-2747.
21. Bai A, Lu N, Guo Y, Liu Z, Chen J, et al. (2009) All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. J Leukoc Biol 86: 959-969.
22. Wermers JD, McNamee EN, Wurbel MA, Jedlicka P, Rivera-Nieves J (2011) The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice. Gastroenterology 140: 1526-1535.
23. Danese S (2012) New therapies for inflammatory bowel disease: from bench to the bedside. Gut 61: 918-932.
24. Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, et al. (2003) Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52: 65-70.
25. Wang C, Kang SG, HogenEsch H, Love PE, Kim CH (2010) Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol 184: 5519-5526.
26. Cha HR, Chang SY, Chang JH, Kim JO, Yang JY, et al. (2010) Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. J Immunol 184: 6799-6806.
27. Lees CW, Barrett JC, Parkes M, Satsangi J (2011) New IBD genetics: Common pathways with other diseases. Gut 60: 1739-1753.