Sexual dysfunction in patients with alcohol and opioid dependence

Indian Journal of Psychological Medicine

Volumn 36, Issue 4, 2014, Pages 355-365

  Grover, Sandeep ^a   Mattoo, Surendra K ^a   Pendharkar, Shreyas ^a   Kandappan, Venkatesh ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Alcohol; opioids; sexual dysfunction

Indexed keywords

EID: 84907500704     PISSN: 02537176     EISSN: 09751564     Source Type: Journal    
DOI: 10.4103/0253-7176.140699     Document Type: Review

References (93)

1. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. JAMA 1999; 281: 537-44. Erratum in: JAMA 1999; 281: 1174-5.
2. Moreira ED, Glasser DB, Nicolosi A, Duarte FG, Gingell C, GSSAB Investigators' Group. Sexual problems and help-seeking behaviour in adults in the United Kingdom and continental Europe. BJU Int 2008; 101: 1005-11.
3. Obot IS, Poznyak V, Monteiro M. From basic research to public health policy: WHO report on the neuroscience of substance dependence. Addict Behav 2004; 29: 1497-502.
4. World Health Organization. Alcohol Use and Sexual Risk Behaviour: A Cross-Cultural Study in Eight Countries. Geneva: World Health Organization; 2005.
5. Peugh J, Belenko S. Alcohol, drugs and sexual function: A review. J Psychoactive Drugs 2001; 33: 223-32.
6. James G. Opioids and sexual behaviour. Neurosci Biobehav Rev 1986; 11: 1-34.
7. Sullivan ME, Keoghane SR, Miller MA. Vascular risk factors and erectile dysfunction. BJU Int 2001; 87: 838-45.
8. Zaazaa A, Bella AJ, Shamloul R. Drug addiction and sexual dysfunction. Endocrinol Metab Clin North Am 2013; 42: 585-92.
9. Leinonen P, Bolton N, Vihko R. Human testicular LH receptors: Correlations with circulating gonadotrophins and testicular steroid secretion. Int J Androl 1982; 5: 145-57.
10. Azizi F, Vagenakis AG, Longcope C, Ingbar SH, Braverman LE. Decreased serum testosterone concentration in male heroin and methadone addicts. Steroids 1973; 22: 467-72.
11. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 2010; 31: 98-132.
12. Lafisca S, Bolelli G, Franceschetti F, Danieli A, Tagliaro F, Marigo M, et al. Free and bound testosterone in male heroin addicts. Arch Toxicol Suppl 1985; 8: 394-7.
13. Wang C, Chan V, Yeung RT. The effect of heroin addiction on pituitary-testicular function. Clin Endocrinol (Oxf) 1978; 9: 455-61.
14. Ragni G, De Lauretis L, Bestetti O, Sghedoni D, Gambaro V. Gonadal function in male heroin and methadone addicts. Int J Androl 1988; 11: 93-100.
15. Fabbri A, Jannini EA, Gnessi L, Moretti C, Ulisse S, Franzese A, et al. Endorphins in male impotence: Evidence for naltrexone stimulation of erectile activity in patient therapy. Psychoneuroendocrinology 1989; 14: 103-11.
16. Daniell HW. DHEAS deficiency during consumption of sustained-action prescribed opioids: Evidence for opioid-induced inhibition of adrenal androgen production. J Pain 2006; 7: 901-7.
17. Nordmann R, Ribière C, Rouach H. Ethanol-induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcohol Alcohol 1990; 25: 231-7.
18. Rivier C, Rivest S, Vale W. Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: Possible mechanisms. Alcohol Clin Exp Res 1992; 16: 935-41.
19. Hadley ME. Endocrinology. Englewoods Cliff, New Jersey: Prentice Hall; 1988.
20. Yen SS, Jaffe RB. Reproductive Endocrinology. Philadelphia: WB Saunders Company; 1991.
21. Cicero TJ. Alcohol-induced deficits in the hypotha lamic-pituitary-luteinizing hormone axis in the male. Alcohol Clin Exp Res 1982; 6: 207-15.
22. Salonen I, Pakarinen P, Huhtaniemi I. Effect of chronic ethanol diet on expression of gonadotropin genes in the male rat. J Pharmacol Exp Ther 1992; 260: 463-7.
23. Little PJ, Adams ML, Cicero TJ. Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the developing male rat. J Pharmacol Exp Ther 1992; 263: 1056-61.
24. Gianoulakis C. Characterization of the effects of acute ethanol administration on the release of beta-endorphin peptides by the rat hypothalamus. Eur J Pharmacol 1990; 180: 21-9.
25. Yin D, Mufson RA, Wang R, Shi Y. Fas-mediated cell death promoted by opioids. Nature 1999; 397: 218.
26. Nanji AA, Hiller-Sturmhöfel S. Apoptosis and necrosis: Two types of cell death in alcoholic liver disease. Alcohol Health Res World 1997; 21: 325-30.
27. Adams ML, Nock B, Truong R, Cicero TJ. Nitric oxide control of steroidogenesis: Endocrine effects of NG-nitro-L-arginine and comparisons to alcohol. Life Sci 1992; 50: PL35-40.
28. Sies H. Oxidative stress: Oxidants and antioxidants. Exp Physiol 1997; 82: 291-5.
29. Aleynik SI, Leo MA, Aleynik MK, Lieber CS. Increased circulating products of lipid peroxidation in patients with alcoholic liver disease. Alcohol Clin Exp Res 1998; 22: 192-6.
30. Emanuele NV, LaPagli N, Steiner J, Colantoni A, Van Thiel DH, Emanuele MA. Peripubertal paternal EtOH exposure. Endocrine 2001; 14: 213-9.
31. Anderson RA Jr, Quigg JM, Oswald C, Zaneveld LJ. Demonstration of a functional blood-testis barrier to acetaldehyde. Evidence for lack of acetaldehyde effect on ethanol-induced depression of testosterone in vivo. Biochem Pharmacol 1985; 34: 685-95.
32. Vaubourdolle M, Guechot J, Chazouilleres O, Poupon RE, Giboudeau J. Effect of dihydrotestosterone on the rate of ethanol elimination in healthy men. Alcohol Clin Exp Res 1991; 15: 238-40.
33. Stammel W, Thomas H, Staib W, Kühn-Velten WN. Tetrahydroisoquinoline alkaloids mimic direct but not receptor-mediated inhibitory effects of estrogens and phytoestrogens on testicular endocrine function. Possible significance for Leydig cell insufficiency in alcohol addiction. Life Sci 1991; 49: 1319-29.
34. Mintz J, O'Hare K, O'Brien CP, Goldschmidt J. Sexual problems of heroin addicts. Arch Gen Psychiatry 1974; 31: 700-3.
35. Hanbury R, Cohen M, Stimmel B. Adequacy of sexual performance in men maintained on methadone. Am J Drug Alcohol Abuse 1977; 4: 13-20.
36. Spring WD Jr, Willenbring ML, Maddux TL. Sexual dysfunction and psychological distress in methadone maintenance. Int J Addict 1992; 27: 1325-34.
37. Teusch L, Scherbaum N, Böhme H, Bender S, Eschmann-Mehl G, Gastpar M. Different patterns of sexual dysfunctions associated with psychiatric disorders and psychopharmacological treatment. Results of an investigation by semistructured interview of schizophrenic and neurotic patients and methadonesubstituted opiate addicts. Pharmacopsychiatry 1995; 28: 84-92.
38. Palha AP, Esteves M. A study of the sexuality of opiate addicts. J Sex Marital Ther 2002; 28: 427-37.
39. Brown R, Balousek S, Mundt M, Fleming M. Methadone maintenance and male sexual dysfunction. J Addict Dis 2005; 24: 91-106.
40. Bliesener N, Albrecht S, Schwager A, Weckbecker K, Lichtermann D, Klingmüller D. Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence. J Clin Endocrinol Metab 2005; 90: 203-6.
41. Wu CJ, Hsieh JT, Lin JS, Hwang TI, Jiann BP, Huang ST, et al. Comparison of prevalence between self-reported erectile dysfunction and erectile dysfunction as defined by five-item International Index of Erectile Function in Taiwanese men older than 40 years. Urology 2007; 69: 743-7.
42. Hallinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia J. Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment. J Sex Med 2008; 5: 684-92.
43. Quaglio G, Lugoboni F, Pattaro C, Melara B, G.I.C.S., Mezzelani P, et al. Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment. Drug Alcohol Depend 2008; 94: 12-8.
44. Bang-Ping J. Sexual dysfunction in men who abuse illicit drugs: A preliminary report. J Sex Med 2009; 6: 1072-80.
45. Tufani KH, Afshari R. Opioid induced erectile dysfunction. Proceeding of 8th Annual Congress of the Asia Pacific of Medical Toxicology. Beijing, China; 2009.
46. Cioe PA, Friedmann PD, Stein MD. Erectile dysfunction in opioid users: Lack of association with serum testosterone. J Addict Dis 2010; 29: 455-60.
47. Chekuri V, Gerber D, Brodie A, Krishnadas R. Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. Addict Behav 2012; 37: 124-6.
48. Wong D, Gray DP, Simmonds M, Rashiq S, Sobolev I, Morrish DW. Opioid analgesics suppress male gonadal function but opioid use in males and females does not correlate with symptoms of sexual dysfunction. Pain Res Manag 2011; 16: 311-6.
49. Zhang Y, Wang P, Ma Z, Xu Z, Li Y. Sexual function of 612 male addicts treated by methadone. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011; 36: 739-43.
50. Chen W, Li X, Li X, Ling L, Xia Y, Chen J, et al. Erectile dysfunction among male heroin addicts receiving methadone maintenance treatment in Guangdong, China. J Addict Med 2012; 6: 212-8.
51. Babakhanian M, Alam Mehrjerdi Z, Shenaiy Y. Sexual dysfunction in male crystalline heroin dependents before and after MMT: A pilot study. Arch Iran Med 2012; 15: 751-5.
52. Trajanovska AS, Vujovic V, Ignjatova L, Janicevic-Ivanovska D, Cibisev A. Sexual dysfunction as a side effect of hyperprolactinemia in methadone maintenance therapy. Med Arch 2013; 67: 48-50.
53. Xia Y, Zhang D, Li X, Chen W, He Q, Jahn HJ, et al. Sexual dysfunction during methadone maintenance treatment and its influence on patient's life and treatment: A qualitative study in South China. Psychol Health Med 2013; 18: 321-9.
54. Vallejo-Medina P, Sierra JC. Effect of drug use and influence of abstinence on sexual functioning in a Spanish male drug-dependent sample: A multisite study. J Sex Med 2013; 10: 333-41.
55. Nik Jaafar NR, Mislan N, Abdul Aziz S, Baharudin A, Ibrahim N, Midin M, et al. Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy. J Sex Med 2013; 10: 2069-76.
56. Ramdurg S, Ambekar A, Lal R. Sexual dysfunction among male patients receiving buprenorphine and naltrexone maintenance therapy for opioid dependence. J Sex Med 2011; 10: 1743-61.
57. Mattoo SK, Bhardawaj V, Aarya K, Basu D. Sexual functioning in substance dependent men attending a de-addiction centre. Paper Presented at the Annual National Conference of the Indian Psychiatric Society; 2008-2009.
58. Cioe PA, Anderson BJ, Stein MD. Change in symptoms of erectile dysfunction in depressed men initiating buprenorphine therapy. J Subst Abuse Treat 2013; 45: 451-6.
59. Lemere F, Smith JW. Alcohol-induced sexual impotence. Am J Psychiatry 1973; 130: 212-3.
60. Fahrner EM. Sexual dysfunction in male alcohol addicts: Prevalence and treatment. Arch Sex Behav 1987; 16: 247-57.
61. O'Farrell TJ, Choquette KA, Birchler GR. Sexual satisfaction and dissatisfaction in the marital relationships of male alcoholics seeking marital therapy. J Stud Alcohol 1991; 52: 441-7.
62. Stankvshve T, Protic M, Shishkova. Disturbances of sexual function in alcoholics (in Bulgarian). Nevro Psikhiat Nevrokhir Sofiya 1974; 13: 409-15.
63. Akhtar MJ. Sexual disorders in male alcoholics. In: Madden J, Walker I, Kenyoon LM, editors. Alcoholism and Drug Dependence. New York: Plenum Press; 1977. p. 3-13.
64. Whalley LJ. Sexual adjustment of male alcoholics. Acta Psychiatr Scand 1978; 58: 281-98.
65. van Thiel DH, Lester R. Hypothalamic-pituitary gonadal dysfunction in patients with alcoholic liver disease. In: Davidson CS, editor. Problems in Liver Disease. New York: Stratton Intercontinental Medical Book Corp.; 1979. p. 289-98.
66. Jensen SB. Sexual customs and dysfunction in alcoholics. Br J Sex Med 1979; 6: 30-4.
67. Vijayasenan ME. Alcohol and sex. N Z Med J 1981; 93: 18-20.
68. Mandell W, Miller CM. Male sexual dysfunction as related to alcohol consumption: A pilot study. Alcohol Clin Exp Res 1983; 7: 65-9.
69. Jensen SB. Sexual function and dysfunction in younger married alcoholics. A comparative study. Acta Psychiatr Scand 1984; 69: 543-9.
70. Jensen SB, Gluud C. Sexual dysfunction in men with alcoholic liver cirrhosis. A comparative study. Liver 1985; 5: 94-100.
71. Wylie KR, Steward D, Seivewright N, Smith D. Prevalence of sexual dysfunction in three psychiatric outpatient settings: A drug misuse service, an alcohol misuse service and a general adult psychiatry clinic. Sex Relat Ther 2002; 17: 149-60.
72. Paparriropoulos T, Zabelis T, Tzavellas E, Karaiskos D, Zaloni R, Stachtea1 X, et al. Sexual dysfunction and alcohol abuse. Eur Neuropsychopharmacol 2009; 19: S6-7.
73. Grinshpoon A, Margolis A, Weizman A, Ponizovsky AM. Sildenafil citrate in the treatment of sexual dysfunction and its effect on quality of life in alcohol dependent men: Preliminary findings. Alcohol Alcohol 2007; 42: 340-6.
74. Dissiz M, Oskay ÜY. Evaluation of sexual functions in Turkish alcohol-dependent males. J Sex Med 2011; 8: 3181-7.
75. Lee AC, Ho LM, Yip AW, Fan S, Lam TH. The effect of alcohol drinking on erectile dysfunction in Chinese men. Int J Impot Res 2010; 22: 272-8.
76. Krupnov AN, Shustov DI, Novikov SA, Kiselev DN. Peculiarities of erectile dysfunction in men with alcohol dependence. Zh Nevrol Psikhiatr Im S S Korsakova 2011; 111: 55-7.
77. Pandey AK, Sapkota N, Tambi A, Shyangwa PM. Clinicodemographic profile, sexual dysfunction and readiness to change in male alcohol dependence syndrome inpatients in a tertiary hospital. Nepal Med Coll J 2012; 14: 35-40.
78. McCambridge J, Mitcheson L, Hunt N, Winstock A. The rise of Viagra among British illicit drug users: 5-year survey data. Drug Alcohol Rev 2006; 25: 111-3.
79. Rosen RC. Alcohol and drug effects on sexual response: Human experimental and clinical studies. Annu Rev Sex Res 1991; 2: 119-79.
80. Okulate G, Olayinka O, Dogunro AS. Erectile dysfunction: Prevalence and relationship to depression, alcohol abuse and panic disorder. Gen Hosp Psychiatry 2003; 25: 209-13.
81. Asboe D, Catalan J, Mandalia S, Dedes N, Florence E, Schrooten W, et al. Sexual dysfunction in HIV-positive men is multi-factorial: A study of prevalence and associated factors. AIDS Care 2007; 19: 955-65.
82. Chew KK, Bremner A, Stuckey B, Earle C, Jamrozik K. Alcohol consumption and male erectile dysfunction: An unfounded reputation for risk? J Sex Med 2009; 6: 1386-94.
83. Cheng JY, Ng EM, Chen RY, Ko JS. Alcohol consumption and erectile dysfunction: Meta-analysis of population-based studies. Int J Impot Res 2007; 19: 343-52.
84. Fagan PJ, Schmidt CW Jr, Wise TN, Derogatis LR. Alcoholism in patients with sexual disorders. J Sex Marital Ther 1988; 14: 245-52.
85. Masters W, Johnson VE. In: Human Sexual Inadequacy. Boston: Little Brown; 1970.
86. Lianjun P, Aixia Z, Zhong W, Feng P, Li B, Xiaona Y. Risk factors for low sexual function among urban Chinese women: A hospital-based investigation. J Sex Med 2011; 8: 2299-304.
87. Snyder S, Karacan I. Effects of chronic alcoholism on nocturnal penile tumescence. Psychosom Med 1981; 43: 423-9.
88. Snyder S, Karacan I, Salis PJ. Disulfiram and nocturnal penile tumescence in the chronic alcoholic. Biol Psychiatry 1981; 16: 399-406.
89. Crowley TJ, Simpson R. Methadone dose and human sexual behavior. Int J Addict 1978; 13: 285-95.
90. Jackson G. The importance of risk factor reduction in erectile dysfunction. Curr Urol Rep 2007; 8: 463-6.
91. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. A prospective study of risk factors for erectile dysfunction. J Urol 2006; 176: 217-21.
92. Carvalho J, Nobre P. Biopsychosocial determinants of men's sexual desire: Testing an integrative model. J Sex Med 2011; 8: 754-63.
93. Quinta Gomes AL, Nobre P. Early maladaptive schemas and sexual dysfunction in men. Arch Sex Behav 2012; 41: 311-20.