Yeast mutation accumulation experiment supports elevated mutation rates at highly transcribed sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 39, 2014, Pages E4062-

  Chen, Xiaoshu ^a   Zhang, Jianzhi ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC VARIABILITY; GENETICS; MUTATION RATE; SACCHAROMYCES CEREVISIAE;

GENETIC VARIATION; MUTATION RATE; SACCHAROMYCES CEREVISIAE;

EID: 84907482328     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412284111     Document Type: Letter

References (5)

1. Park C, Qian W, Zhang J (2012) Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Rep 13(12): 1123-1129.
2. Chen X, Zhang J (2013) No gene-specific optimization of mutation rate in Escherichia coli. Mol Biol Evol 30(7):1559-1562.
3. Lind PA, Andersson DI (2008) Whole-genome mutational biases in bacteria. Proc Natl Acad Sci USA 105(46):17878-17883.
4. Zhu YO, Siegal ML, Hall DW, Petrov DA (2014) Precise estimates of mutation rate and spectrum in yeast. Proc Natl Acad Sci USA 111(22):E2310-E2318.
5. Churchman LS, Weissman JS (2011) Nascent transcript sequencing visualizes transcription at nucleotide resolution. Nature 469(7330): 368-373.