Comment on "controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-b pathway"-Smad2/3 activity does not predict the dynamics of transcription

Science Signaling

Volumn 7, Issue 344, 2014, Pages 1c1-

  Warmflash, Aryeh ^a,b   Zhang, Qixiang ^a   Brivanlou, Ali H ^a   Siggia, Eric D ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL STIMULATION; CELL SURFACE; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR DYNAMICS; PREDICTION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REFRACTORY PERIOD; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; METABOLISM; PHYSIOLOGY;

HUMANS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84907479495     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005562     Document Type: Article

References (6)

1. P. Vizán, D. S. Miller, I. Gori, D. Das, B. Schmierer, C. S. Hill, Controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-b pathway. Sci. Signal. 6, ra106 (2013)
2. A. Warmflash, Q. Zhang, B. Sorre, A. Vonica, E. D. Siggia, A. H. Brivanlou, Dynamics of TGF-b signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc. Natl. Acad. Sci. U.S.A. 109, E1947-E1956 (2012)
3. G. J. Inman, F. J. Nicolás, J. F. Callahan, J.D. Harling, L. M. Gaster, A. D. Reith, N. J. Laping, C. S. Hill, SB-431542 is a potent and specific inhibitor of transforming growth factor-b superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62, 65-74 (2002)
4. G. J. Inman, F. J. Nicolás, C. S. Hill, Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-b receptor activity. Mol. Cell 10, 283-294 (2002)
5. B. Sorre, A. Warmflash, A. H. Brivanlou, E. D. Siggia, Encoding of temporal signals by the TGF-b pathway and implications for embryonic patterning. Dev. Cell 30, 334-342 (2014)
6. Z. Zi, Z. Feng, D. A. Chapnick, M. Dahl, D. Deng, E. Klipp, A. Moustakas, X. Liu, Quantitative analysis of transient and sustained transforming growth factor-b signaling dynamics. Mol. Syst. Biol. 7, 492 (2011)