Tofacitinib versus Methotrexate in Rheumatoid Arthritis

New England Journal of Medicine

Volumn 371, Issue 12, 2014, Pages 1163-1165

  Sexton, Donal ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYCLOSPORIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHOTREXATE; TOFACITINIB; ANTIRHEUMATIC AGENT; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ALLOGRAFT; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DISEASE EXACERBATION; DRUG EFFICACY; GRAFT REJECTION; HUMAN; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; KIDNEY TUBULE FUNCTION; LETTER; PREVALENCE; PROTEINURIA; RHEUMATOID ARTHRITIS; FEMALE; MALE; NOTE; CARDIOVASCULAR DISEASE; DOSE KIDNEY FUNCTION RELATION; DRUG HALF LIFE; DRUG SAFETY; KIDNEY DISEASE; KIDNEY GRAFT REJECTION; KIDNEY TUBULE EXCRETION;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; FEMALE; HUMANS; MALE; METHOTREXATE; PIPERIDINES; PYRIMIDINES; PYRROLES;

EID: 84907407610     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1408607     Document Type: Letter

References (5)

1. Lee EB, Fleischmann R, Hall S, et al. Tofacitinib versus methotrexate in rheumatoid arthritis. N Engl J Med 2014;370: 2377-86.
2. Karstila K, Korpela M, Sihvonen S, Mustonen J. Prognosis of clinical renal disease and incidence of new renal findings in patients with rheumatoid arthritis: follow-up of a populationbased study. Clin Rheumatol 2007;26:2089-95.
3. del Rincón ID, Williams K, Stern MP, Freeman GL, Escalante A. High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum 2001;44:2737-45.
4. Krishnaswami S, Chow V, Boy M, Wang C, Chan G. Pharmacokinetics of tofacitinib, a Janus kinase inhibitor, in patients with impaired renal function and end-stage renal disease. J Clin Pharmacol 2014;54:46-52.
5. Vincenti F, Tedesco Silva H, Busque S, et al. Randomized phase 2b trial of tofacitinib (CP-690, 550) in de novo kidney transplant patients: efficacy, renal function and safety at 1 year. Am J Transplant 2012;12:2446-56.