Role of decidual natural killer cells, interleukin-15, and interferon-γ in placental development and preeclampsia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 307, Issue 5, 2014, Pages

  Sones, Jenny L ^a   Lob, Heinrich E ^a   Isroff, Catherine E ^a   Davisson, Robin L ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Decidual natural killer cells; Placenta; Preeclampsia

Indexed keywords

ANGIOGENIC FACTOR; GAMMA INTERFERON; INTERLEUKIN 15; MESSENGER RNA;

CELL ACTIVATION; CELL COUNT; DECIDUALIZATION; DISEASE COURSE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HYPERTENSION; NATURAL KILLER CELL; NIDATION; NONHUMAN; PERINATAL MORBIDITY; PERINATAL MORTALITY; PLACENTA DEVELOPMENT; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PRIORITY JOURNAL; PROTEINURIA; REVIEW; ROLE PLAYING;

DECIDUAL NATURAL KILLER CELLS; PLACENTA; PREECLAMPSIA;

ANIMALS; CYTOKINES; DECIDUA; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-15; KILLER CELLS, NATURAL; NEOVASCULARIZATION, PHYSIOLOGIC; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; RNA, MESSENGER; UTERUS;

EID: 84907359933     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00176.2014     Document Type: Review

References (17)

1. Ashkar AA, Croy BA. Interferon-gamma contributes to the normalcy of murine pregnancy. Biol Reprod 61: 493-502, 1999.
2. Bachmayer N, Rafik Hamad R, Liszka L, Bremme K, Sverremark-Ekstrom E. Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia. Am J Reprod Immunol 56: 292-301, 2006.
3. Barber EM, Pollard JW. The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. J Immunol 171: 37-46, 2003.
4. Burke SD, Barrette VF, Gravel J, Carter AL, Hatta K, Zhang J, Chen Z, Leno-Duran E, Bianco J, Leonard S, Murrant C, Adams MA, Croy BA. Uterine NK cells, spiral artery modification and the regulation of blood pressure during mouse pregnancy. Am J Reprod Immunol 63: 472-481, 2010.
5. Croy BA, Chantakru S, Esadeg S, Ashkar AA, Wei Q. Decidual natural killer cells: key regulators of placental development (Review). J Reprod Immunol 57: 151-168, 2002.
6. Davisson RL, Hoffmann DS, Butz GM, Aldape G, Schlager G, Merrill DC, Sethi S, Weiss RM, Bates JN. Discovery of a spontaneous genetic mouse model of preeclampsia. Hypertension 39: 337-342, 2002.
7. Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H. Molecular cues to implantation. Endocr Rev 25: 341-373, 2004.
8. Dokras A, Hoffmann DS, Eastvold JS, Kienzle MF, Gruman LM, Kirby PA, Weiss RM, Davisson RL. Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia. Biol Reprod 75: 899 -907, 2006.
9. Erlebacher A. Immunology of the maternal-fetal interface. Annu Rev Immunol 31: 387-411, 2013.
10. Herington JL, Bany BM. Effect of the conceptus on uterine natural killer cell numbers and function in the mouse uterus during decidualization. Biol Reprod 76: 579 -588, 2007.
11. Hu W, Wang H, Wang Z, Huang H, Dong M. Elevated serum levels of interleukin-15 and interleukin-16 in preeclampsia. J Reprod Immunol 73: 166 -171, 2007.
12. Murphy SP, Tayade C, Ashkar AA, Hatta K, Zhang J, Croy BA. Interferon gamma in successful pregnancies. Biol Reprod 80: 848-859, 2009.
13. Soto E, Romero R, Kusanovic JP, Ogge G, Hussein Y, Yeo L, Hassan SS, Kim CJ, Chaiworapongsa T. Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion. J Matern Fetal Neonatal Med 25: 498-507, 2011.
14. Torry DS, Hinrichs M, Torry RJ. Determinants of placental vascularity. Am J Reprod Immunol 51: 257-268, 2004.
15. Toth B, Haufe T, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U. Placental interleukin-15 expression in recurrent miscarriage. Am J Reprod Immunol 64: 402-410, 2010.
16. Wallace AE, Host AJ, Whitley GS, Cartwright JE. Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. Am J Pathol 183: 1853-1861, 2013.
17. Williams PJ, Bulmer JN, Searle RF, Innes BA, Robson SC. Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy. Reproduction 138: 177-184, 2009.