Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocardium via PPARγ activation?

Antioxidants and Redox Signaling

Volumn 21, Issue 8, 2014, Pages 1156-1163

  Anderson, Ethan J ^a   Thayne, Kathleen A ^a   Harris, Mitchel ^a   Shaikh, Saame Raza ^a   Darden, Timothy M ^a   Lark, Daniel S ^a   Williams, John Mark ^a   Chitwood, W Randolph ^a   Kypson, Alan P ^a   Rodriguez, Evelio ^a,b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b Saint Thomas Heart Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 ACID ETHYL ESTER; OMEGA 3 FATTY ACID; PALMITOYLCARNITINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ANTIOXIDANT;

AGED; ANTIOXIDANT ACTIVITY; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; DISSECTION; DRUG MEGADOSE; ELECTIVE SURGERY; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION; HEALTH CARE QUALITY; HEART ATRIUM; HEART MUSCLE; HEART PROTECTION; HEART RIGHT ATRIUM; HEART SURGERY; HUMAN; HUMAN TISSUE; LIPID COMPOSITION; MALE; MITOCHONDRIAL RESPIRATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; TRANSACTIVATION; UPREGULATION; DRUG EFFECTS; HEART DISEASES; HEART MITOCHONDRION; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

AGED; ANTIOXIDANTS; FATTY ACIDS, OMEGA-3; FEMALE; GENE EXPRESSION; HEART ATRIA; HEART DISEASES; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA, HEART; MYOCARDIUM; OXIDATION-REDUCTION; PPAR GAMMA; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD;

EID: 84907356646     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.5888     Document Type: Review

References (9)

1. Anderson EJ, Thayne K, Harris M, Carraway K, and Shaikh SR. Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids. Biochem J 441: 359-366, 2012
2. De Caterina R. n-3 fatty acids in cardiovascular disease. N Engl J Med 364: 2439-2450, 2011
3. Fisher-Wellman KH, Mattox TA, Thayne K, Katunga LA, La Favor JD, Neufer PD, Hickner RC, Wingard CJ, and Anderson EJ. Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle. J Physiol 591: 3471-3486, 2013
4. Gao G and Dudley SC, Jr. Redox regulation, NF-kappaB, and atrial fibrillation. Antioxid Redox Signal 11: 2265-2277, 2009
5. Metcalf RG, James MJ, Gibson RA, Edwards JR, Stubberfield J, Stuklis R, Roberts-Thomson K, Young GD, and Cleland LG. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr 85: 1222-1228, 2007
6. Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, Latini R, Libby P, Lombardi F, O"Gara PT, Page RL, Tavazzi L, and Tognoni G. Fish oil and postoperative atrial fibrillation: The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA 308: 2001-2011, 2012
7. Mozaffarian D and Wu JH. Omega-3 Fatty acids and cardiovascular disease: Effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58: 2047-2067, 2011
8. Sandesara CM, Chung MK, Van Wagoner DR, Barringer TA, Allen K, Ismail HM, Zimmerman B, and Olshansky B. A randomized, placebo-controlled trial of omega-3 fatty acids for inhibition of supraventricular arrhythmias after cardiac surgery: The FISH trial. J Am Heart Assoc 1: E000547, 2012
9. Saravanan P, Bridgewater B, West AL, O'Neill SC, Calder PC, and Davidson NC. Omega-3 fatty acid supplementation Does not reduce risk of atrial fibrillation after coronary artery bypass surgery: A randomized, double-blind, placebocontrolled clinical trial. Circ Arrhythm Electrophysiol 3: 46-53, 2010