Deoxyxylulose 5-phosphate reductoisomerase is not a rate-determining enzyme for essential oil production in spike lavender

Journal of Plant Physiology

Volumn 171, Issue 17, 2014, Pages 1564-1570

  Mendoza Poudereux, Isabel ^a   Muñoz Bertomeu, Jesús ^a,b   Arrillaga, Isabel ^a   Segura, Juan ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b Ciudad Politécnica de la Innovación   (Spain)

Author keywords

DXR enzyme; DXS enzyme; Essential oil; Monoterpene; Spike lavender

Indexed keywords

1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; 2-C-METHYLERYTHRITOL 4-PHOSPHATE; ARABIDOPSIS PROTEIN; CAROTENOID; CHLOROPHYLL; DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE; ERYTHRITOL; ESSENTIAL OIL; ISOMERASE; SUGAR PHOSPHATE; TERPENE; TRANSFERASE; VEGETABLE OIL; VEGETABLE PROTEIN;

ANALOGS AND DERIVATIVES; CHEMISTRY; ENZYMOLOGY; FLOWER; GENE EXPRESSION; GENETICS; LAVENDER; METABOLISM; PHENOTYPE; PLANT LEAF; TRANSGENIC PLANT;

ALDOSE-KETOSE ISOMERASES; ARABIDOPSIS PROTEINS; CAROTENOIDS; CHLOROPHYLL; ERYTHRITOL; FLOWERS; GENE EXPRESSION; LAVANDULA; MONOTERPENES; OILS, VOLATILE; PHENOTYPE; PLANT LEAVES; PLANT OILS; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; SUGAR PHOSPHATES; TRANSFERASES;

EID: 84907339914     PISSN: 01761617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jplph.2014.07.012     Document Type: Article

References (41)

1. Bede J.C., Musser R.O., Felton G.W., Korth K.L. Caterpillar herbivory and salivary enzymes decrease transcript levels of Medicago truncatula genes encoding early enzymes in terpenoid biosynthesis. Plant Mol Biol 2006, 60:519-531.
2. Calvo M.C., Segura J. In vitro morphogenesis from explants of Lavandula latifolia and Lavandula stoechas seedlings. Sci Hortic 1998, 36:131-137.
3. Carretero-Paulet L., Ahumanda I., Cunillera N., Rodríguez-Concepción M., Ferrer A., Boronat A., et al. Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-d-erythritol 4-phosphate pathway. Plant Physiol 2002, 129:1581-1591.
4. Carretero-Paulet L., Cairó A., Botella-Pavía P., Besumbes O., Campos N., Boronat A., et al. Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxyxylulose 5-phosphate reductoisomerase. Plant Mol Biol 2006, 62:683-695.
5. Cordoba E., Salmi M., León P. Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants. J Exp Bot 2009, 60:2933-2943.
6. Dudareva N., Andersson S., Orlova I., Gatto N., Reichelt M., Rhodes D., et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. Proc Natl Acad Sci U S A 2005, 102:933-938.
7. Dudareva N., Klempien A., Muhlemann J.K., Kaplan I. Biosynthesis, function and metabolic engineering of plant volatile organic compounds. N Phytol 2013, 198:16-32.
8. Enfissi E.M.A., Fraser P.D., Lois L.M., Boronat A., Schuch W., Bramley P.M. Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. Plant Biotechnol J 2005, 3:17-28.
9. Estévez J.M., Cantero A., Reindl A., Reichler S., León P. 1-Deoxy-d-xylulose 5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants. J Biol Chem 2001, 25:22901-22909.
10. Gershenzon J., Dudareva N. The function of terpene natural products in the natural world. Nat Chem Biol 2007, 3:408-414.
11. Hans J., Hause B., Strack D., Walter M.H. Cloning, characterization, and immunolocalization of a mycorrhiza inducible 1-deoxy-d-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize. Plant Physiol 2004, 134:614-624.
12. Harker M., Bramley P.M. Expression of prokaryotic 1-deoxy-d-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis. FEBS Lett 1999, 448:115-119.
13. Hasumuna T., Takeno S., Hayashi S., Sendai M., Bamba T., Yoshimura S., et al. Overexpression of 1-deoxy-d-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid production. J Biosci Bioeng 2008, 1005:518-526.
14. Hsieh M.H., Chang C.Y., Hsu S.J., Chen J.J. Chloroplast localization of methylerythritol 4-phosphate pathway enzymes and regulation of mitochondrial genes in IspD and IspE albino mutants in Arabidopsis. Plant Mol Biol 2008, 66:663-673.
15. Hsieh M.H., Goodman H.M. The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Plant Physiol 2005, 138:641-653.
16. Kuzuyama T., Takahashi S., Seto H. Characterization of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues. J Biol Chem 2000, 275:19928-19932.
17. Lange B.M., Ahkami A. Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes-current status and future opportunities. Plant Biotechnol J 2013, 11:169-196.
18. Lange B.M., Mahmoud S.S., Wildung M.R., Turner G.W., Davis E.M., Lange I., et al. Improving peppermint essential oil yield and composition by metabolic engineering. Proc Natl Acad Sci U S A 2011, 108:16944-16949.
19. Leivar P., Antolin-Llovera M., Ferrero S., Closa M., Arro M., Ferrer A., et al. Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A. Plant Cell 2011, 23:1494-1511.
20. Leivar P., González V.M., Castel S., Trelease R.N., López-Iglesias C., Arró M., et al. Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase. Plant Physiol 2005, 137:57-69.
21. Lichtenthaler H.K. Chlorophylls and caratenoids: pigments of photosynthetic biomembranes. Methods Enzymol 1987, 148:350-382.
22. Mahmoud S.S., Croteau R.B. Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase. Proc Natl Acad Sci U S A 2001, 98:8915-8920.
23. Manzano D., Fernandez-Busquets X., Schaller H., González V. The metabolic imbalance underlying lesion formation in Arabidopsis thaliana overexpressing farnesyl diphosphate synthase (isoform 1S) leads to oxidative stress and is triggered by the developmental decline of endogenous HMGR activity. Planta 2004, 219:982-992.
24. Mayrhofer S., Teuber M., Zimmer I., Louis S., Fischbach R.J., Schnitzler J.P. Diurnal and seasonal variation of isoprene biosynthesis-related genes in grey poplar leaves. Plant Physiol 2005, 139:474-484.
25. McConkey M.E., Gershenzon J., Croteau R.B. Developmental regulation of monoterpene biosynthesis in the glandular trichomes of peppermint. Plant Physiol 2000, 122:215-223.
26. McGarvey D.J., Croteau R. Terpenoid metabolism. Plant Cell 1995, 7:1015-1026.
27. Miller B., Heuser T., Zimmer W. Functional involvement of a deoxy-d-xylulose 5-phosphate reductoisomerase gene harboring locus of Synechococcus leopoliensis in isoprenoid biosynthesis. FEBS Lett 2000, 481:221-226.
28. Moses T., Pollier J., Thevelein J.M., Goossens A. Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. N Phytol 2013, 200:27-43.
29. Muñoz-Bertomeu J., Arrillaga I., Ros R., Segura J. Up-regulation of 1-deoxy-d-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender. Plant Physiol 2006, 142:890-900.
30. Muñoz-Bertomeu J., Arrillaga I., Segura J. Essential oil variation within and among natural populations of Lavandula latifolia and its relation to their ecological areas. Biochem Syst Ecol 2007, 35:479-488.
31. Muñoz-Bertomeu J., Ros R., Arrillaga I., Segura J. Expression of spearmint limonene synthase in transgenic spike lavender results in an altered monoterpene composition in developing leaves. Metab Eng 2008, 10:166-177.
32. Muñoz-Bertomeu J., Sales E., Ros R., Arrillaga I., Segura J. Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. Plant Biotechnol J 2007, 5:746-758.
33. Nebauer S.G., Arrillaga I., Castillo-Agudo L., Segura J. Agrobacterium tumefaciens-mediated transformation of the aromatic shrub Lavandula latifolia. Mol Breed 2000, 6:539-552.
34. Pulido P., Perello C., Rodríguez-Concepcion M. New insights into plant isoprenoid metabolism. Mol Plant 2012, 5:964-967.
35. Rodríguez-Concepción M., Ahumada I., Diez-Juez E., Sauret-Güeto S., Lois L.M., Gallego F., et al. 1-Deoxy-d-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening. Plant J 2001, 27:213-222.
36. Rodríguez-Concepción M. Early steps in isoprenoid biosynthesis: multilevel regulation of the supply of common precursors in plant cells. Phytochem Rev 2006, 5:1-15.
37. Simkin A.J., Guirimand G., Papon N., Courdavault V., Thabet I., Ginis O., et al. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. Planta 2011, 234:903-914.
38. Tukey J.W. Some selected quick and easy methods of statistical analysis. Trans N Y Acad Sci 1953, 16:88-97.
39. Veau B., Courtois M., Oudin A., Chenieux J., Rideau M., Clastre M. Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus. Biochim Biophys Acta 2000, 1517:159-163.
40. Walter M.H., Fester T., Strack D. Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with accumulation of the 'yellow pigment' and other apocarotenoids. Plant J 2000, 21:571-578.
41. Xing S., Miao J., Li S., Qin G., Tang S., Li H., et al. Disruption of the 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis. Cell Res 2010, 20:688-700.