Enzyme-linked immunosorbent assay (ELISA) for the detection of use of the synthetic cannabinoid agonists UR-144 and XLR-11 in human urine

Journal of Analytical Toxicology

Volumn 38, Issue 7, 2014, Pages 427-431

  Mohr, Amanda L A ^a   Ofsa, Bill ^b   Keil, Alyssa Marie ^b   Simon, John R ^c   McMullin, Matthew ^b   Logan, Barry K ^a,b  

^a The Center for Forensic Science Research and Education   (United States)

^b NMS Labs   (United States)

^c Tulip Biolabs Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTOR AGONIST; UNCLASSIFIED DRUG; UR 144; VALERIC ACID; XLR 11; (1-PENTYL-1H-INDOL-3-YL)(2,2,3,3-TETRAMETHYLCYCLOPROPYL)METHANONE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; INDOLE DERIVATIVE; XLR-11;

ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORINATION; HUMAN; LIQUID CHROMATOGRAPHY; MEASUREMENT ACCURACY; METABOLITE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE; VALIDATION PROCESS; AGONISTS; PROCEDURES; REPRODUCIBILITY; SUBSTANCE ABUSE;

CANNABINOIDS; CHROMATOGRAPHY, LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INDOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 84907323594     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bku049     Document Type: Article

References (15)

1. Brents, L.K., Reichard, E.E., Zimmerman, S.M., Moran, J.H., Fantegrossi, W.E., Prather, P.L. (2011) Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid receptor affinity and activity. PLoS ONE, 6, 1-9.
2. Forrester, M.B., Kleinschmidt, K., Schwarz, E., Young, A. (2012) Synthetic cannabinoid and marijuana exposures reported to poison centers. Human and Experimental Toxicology, 31, 1006-1011.
3. Kavanagh, P., Grigoryev, A., Savchuk, S., Mikura, I., Formanovsky, A. (2013) UR-144 in products sold via the internet: identification of related compounds and characterization of pyrolysis products. Drug Testing and Analysis, 5, 683-692.
4. Presley, B.C., Jansen, S.A., Logan, B.K. (2013) Analysis of synthetic cannabinoids in botanical material: a review of analytical methods and findings. Forensic Science Review, 25, 27-46.
5. 2012) Drug Enforcement Administration - Office of Diversion Control. UR-144 (TCMP-018; KM-X1) and XLR11 (5-F-UR-144) http://www.deadiversion.usdoj.gov/drug_chem_info/spice/spice_ ur144_xlr11.pdf (accessed Nov 2013).
6. United Nations Office on Drugs and Crime. (2011) Synthetic Cannabinoids in Herbal Products; United Nations Office on Drugs and Crime. http://www.unodc.org/documents/scientific/ Synthetic_Cannabinoids.pdf (accessed Nov 2013).
7. Yeakel, J.K., Logan, B.K. (2013) Blood synthetic cannabinoid concentrations in cases of suspected impaired driving. Journal of Analytical Toxicology, 37, 547-551.
8. Wiley, J.L., Marusich, J.A., Lefever, T.W., Grabenauer, M., Moore, K.N., Thomas, B.F. (2013) Cannabinoids in disguise: D(9)-tetrahydro cannabinol-like effects of tetramethylcyclopropyl ketone indoles. Neuropharmacology, 75C, 145-154.
9. Gurney, S.M.R., Scott, K.S., Kacinko, S.L., Presley, B.C., Logan, B.K. (2014) Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs. Forensic Science Review, 26, 53-78.
10. Sobolevsky, T., Prasolov, I., Rodchenkov, G. (2012) Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids. Drug Testing and Analysis, 5, 745-753.
11. Grigoryev, A., Kavanagh, P., Melnik, A., Savchuk, S., Simonov, A. (2013) Gas and liquid chromatography-mass spectrometry detection of urinary of UR-144 and its major pyrolysis product. Journal of Analytical Toxicology, 37, 265-276.
12. Wohlfarth, A., Pang, S., Mingshe, Z., Gandhi, A.S., Scheidweiler, K.B., Hua-fen, L. et al. (2013) First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained using human hepatocytes and high resolution mass spectrometry. Clinical Chemistry, 59, 1638-1648.
13. Logan, B.K., Kacinko, S.L., Xu, A. (2011) Technical Bulletin: NMS Labs Test for JWH-018, JWH-019, JWH-073, JWH-250, and AM-2201 Primary Monohydroxy Metabolites in Human Urine. http://toxwiki.wikispaces.com/file/view/JWH_metabolites_II_ Technical_Bulletin_vers_1.1.pdf (accessed Sep 2013).
14. Chimalakonda, K.C., Seely, K.A., Bratton, S.M., Brents, L.K., Moran, C.L., Endres, G.W. et al. (2012) Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in 'K2/Spice': identification of novel cannabinoid receptor ligands. The American Society for Pharmacology and Experimental Therapeutics, 40, 2174-2184.
15. Arntson, A., Ofsa, B., Lancaster, D., Simon, J.R., McMullin, M., Logan, B. (2013) Validation of a novel immunoassay for the detection of synthetic cannabinoids and metabolites in urine specimens. Journal of Analytical Toxicology, 37, 284-290.