Recognizing worsening chronic heart failure as an entity and an end point in clinical trials

JAMA

Volumn 312, Issue 8, 2014, Pages 789-790

  Butler, Javed ^a   Braunwald, Eugene ^b   Gheorghiade, Mihai ^c  

^a EMORY UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOTROPIC AGENT; NESIRITIDE;

CARDIOVASCULAR MORTALITY; CLINICAL FEATURE; CLINICAL STUDY; CLINICAL TRIAL (TOPIC); CORONARY ARTERY THROMBOSIS; CORONARY REPERFUSION; DISEASE COURSE; DISEASE REGISTRY; DISEASE SEVERITY; DIURETIC THERAPY; DRUG APPROVAL; DYSPNEA; EMERGENCY CARE; HEART EJECTION FRACTION; HEART FAILURE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; INTERVENTION STUDY; NOMENCLATURE; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY; SYMPTOMATOLOGY;

CLINICAL TRIALS AS TOPIC; DISEASE PROGRESSION; ENDPOINT DETERMINATION; HEART FAILURE; HOSPITALIZATION; HUMANS; REGISTRIES; STROKE VOLUME;

EID: 84907303502     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2014.6643     Document Type: Short Survey

References (9)

1. Goldenberg I, Kutyifa V, Klein HU, et al. Survival with cardiac-resynchronization therapy in mild heart failure. N Engl J Med. 2014;370(18):1694-1701.
2. Publication Committee for the VMAC Investigators (Vasodilatation in the Management of Acute CHF). Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA. 2002;287(12):1531-1540.
3. Ambrosy AP, Fonarow GC, Butler J, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014;63(12):1123-1133.
4. Chen J, Normand SL, Wang Y, Krumholz HM. National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008. JAMA. 2011;306(15):1669-1678.
5. Gheorghiade M, Abraham WT, Albert NM, et al OPTIMIZE-HF Investigators and Coordinators. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA. 2006;296(18):2217-2226. (Pubitemid 44708052)
6. Cuffe MS, Califf RM, Adams KF Jr, et al Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Investigators. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA. 2002;287(12):1541- 1547. (Pubitemid 34269999)
7. Skali H, Dwyer EM, Goldstein R, et al. Prognosis and response to therapy of first inpatient and outpatient heart failure event in a heart failure clinical trial: MADIT-CRT. Eur J Heart Fail. 2014;16(5):560-565.
8. Schrager J, Wheatley M, Georgiopoulou V, et al. Favorable bed utilization and readmission rates for emergency department observation unit heart failure patients. Acad Emerg Med. 2013;20(6):554-561.
9. Ambrosy AP, Pang PS, Khan S, et al EVEREST Trial Investigators. Clinical course and predictive value of congestion during hospitalization in patients admitted for worsening signs and symptoms of heart failure with reduced ejection fraction: findings from the EVEREST trial. Eur Heart J. 2013;34(11):835-843.