Extracellular vesicles as enhancers of virus vector-mediated gene delivery

Human Gene Therapy

Volumn 25, Issue 9, 2014, Pages 785-786

  Fitzpatrick, Zachary ^a,b   György, Bence ^a   Skog, Johan ^c   Maguire, Casey A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c Exosome Diagnostics Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; NEUTRALIZING ANTIBODY; VIRUS GLYCOPROTEIN;

ADENO ASSOCIATED VIRUS; ADENO ASSOCIATED VIRUS SEROTYPE 1; ARTICLE; CELL MEMBRANE; CULTURE MEDIUM; ELECTRON MICROSCOPY; GENE TARGETING; HEPATITIS A VIRUS; LIPID BILAYER; VIRUS PARTICLE; VIRUS SHEDDING; DEPENDOPARVOVIRUS; GENE TRANSFER; GENE VECTOR; GENETICS; PROCEDURES; TRANSPORT VESICLE; ULTRASTRUCTURE; VIROLOGY;

DEPENDOVIRUS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MICROSCOPY, ELECTRON; TRANSPORT VESICLES;

EID: 84907286895     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2014.082     Document Type: Article

References (4)

1. Feng, Z., Hensley, L., McKnight, K.L., et al. (2013). A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature 496, 367-371.
2. Gyö rgy, B., Fitzpatrick, Z., Crommentuijn, M., et al. (2014). Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo. Biomaterials 35, 7598-7609.
3. Maguire, C.A., Balaj, L., Sivaraman, S., et al. (2012).Microvesicleassociated AAV vector as a novel gene delivery system. Mol. Ther. 20, 960-971.
4. Vandenberghe, L.H., Xiao, R., Lock, M., et al. (2010). Efficient serotype-dependent release of functional vector into the culture medium during adeno-associated virus manufacturing. Hum. Gene Ther. 21, 1251-1257.