Cytotoxicity of PEGylated graphene oxide on lymphoma cells

Bio-Medical Materials and Engineering

Volumn 24, Issue 6, 2014, Pages 2135-2141

  Du, Li ^a   Wu, Shaoling ^a   Li, Yanhui ^a   Zhao, Xindong ^a   Ju, Xiaoyan ^a   Wang, Yuzhen ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

CCK 8; Cytotoxicity; Lymphoma cells; PEGylated graphene oxide

Indexed keywords

BIOCOMPATIBILITY; CELLS; CYTOLOGY; CYTOTOXICITY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GRAFTING (CHEMICAL); GRAPHENE; ONCOLOGY; POLYETHYLENE OXIDES; POLYETHYLENES;

BIOLOGICAL SOLUTIONS; CCK-8; CELL VIABILITY; CLINICAL APPLICATION; FT-IR SPECTRUM; GRAPHENE OXIDES; LYMPHOMA CELLS; SURVIVAL RATE;

POLYETHYLENE GLYCOLS;

GRAPHENE OXIDE; MACROGOL; GRAPHITE; MACROGOL DERIVATIVE; NANOCAPSULE; OXIDE;

ANTINEOPLASTIC ACTIVITY; CELL COUNTING; CELL MEMBRANE; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG SOLUBILITY; HUMAN; HUMAN CELL; HYDROPHILICITY; INFRARED SPECTROSCOPY; LYMPHOMA CELL; RAJI CELL LINE; APOPTOSIS; CHEMISTRY; DIFFUSION; DRUG EFFECTS; LYMPHOMA; PARTICLE SIZE; PATHOLOGY; TREATMENT OUTCOME; TUMOR CELL LINE; ULTRASTRUCTURE;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DIFFUSION; GRAPHITE; HUMANS; LYMPHOMA; NANOCAPSULES; OXIDES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; TREATMENT OUTCOME;

EID: 84907278101     PISSN: 09592989     EISSN: 18783619     Source Type: Journal    
DOI: 10.3233/BME-141024     Document Type: Conference Paper

References (24)

1. A.K. Geim and K.S. Novoselov, The rise of graphene, Nat. Mater. 6 (2007), 183-191.
2. K.S. Novoselov, D. Jiang, F. Sehedin, T.J. Booth, V.V. Khotkevich, S.V. Morozov and A.K. Geim, Two-dimensional atomic crystals, Proc. Natl. Acad. Sci. 102 (2005), 10451-10453.
3. Z. Liu, J.T. Robinson, X.M. Sun and H.J. Dai, PEGylated nanographene oxide for delivery of water-insoluble cancer drugs, J. Am. Chem. Soc. 130 (2008), 10876-10877.
4. S.L. Wu, X.D. Zhao, Z.G. Cui, C.T. Zhao, Y.Z. Wang, L. Du and Y.H. Li, Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells, Inter. J. Nanomed. 9 (2014), 1413-1421.
5. L.M. Zhang, J.G. Xia, Q.H. Zhao, L.W. Liu and Z.J. Zhang, Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs, Small 6 (2010), 537-544.
6. S. Park, J.H. An, I.W. Jung, R.D. Piner, S.J. An and X.S. Li, Colloidal suspensions of highly reduced graphene oxide in a wide variety of organic solvents, Nano. Lett. 9 (2009), 1593-1597.
7. D. Li, M.B. Müller, S. Gilje, R.B. Kaner and G.G. Wallace, Processable aqueous dispersions of graphene nanosheets, Nat. Nanotech. 3 (2008), 101-105.
8. M. Wojtoniszak, X.C. Chen, R.J. Kalenczuk, A. Wajda, J. Lapczuk and M. Kurzewski, Synthesis, dispersion, and cytocompatibility of graphene oxide and reduced graphene oxide, Colloids Surface B 89 (2012), 79-85.
9. V.P. Torchilin and V.S. Trubetskoy, Which polymers can make nanoparticulate drug carriers long-circulating? Adv. Drug Deliv. Rev. 16 (1995), 141-155.
10. V.P. Torchilin, Micellar nanocarriers: pharmaceutical perspectives, Pharm. Res. 24 (2007), 1-16.
11. H. Otsuka, Y. Nagasaki and K. Kataoka, PEGylated nanoparticles for biological and pharmaceutical applications, Adv. Drug Deliv. Rev. 55 (2003), 403-419.
12. R.B. Greenwald, Y.H. Choe, J. McGuire and C.D. Conover, Effective drug delivery by PEGylated drug conjugates, Adv. Drug Deliv. Rev. 55 (2003), 217-250.
13. X.M. Sun, Z. Liu, K. Welsher, J.T. Robinson, A. Goodwin, S. Zaric and H.J. Dai, Nano-graphene oxide for cellular imaging and drug delivery, Nano. Res. 1 (2008), 203-212.
14. K. Yang, J. Wan, S. Zhang, Y. Zhang, S.T. Lee and Z. Liu, In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice, ACS Nano. 5 (2011), 516-522.
15. J.Q. Chen, H.Y. Liu, C.B. Zhao, G.Q. Qin, G.N. Xi and T. Li, One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery, Biomaterials 35 (2014), 4986-4995.
16. J.H. Shen, Y.H. Zhu, C. Chen, X.L. Yang and C.Z. Li, Facile preparation and upconversion luminescence of graphene quantum dots, Chem. Commun. 47 (2011), 2580-2582.
17. Y.J. Park, S.Y. Park and I. Insik, Preparation of water soluble graphene using polyethylene glycol: Comparison of covalent approach and noncovalent approach, Ind. Eng. Chem. 17 (2011), 298-303.
18. S. Stankovich, D.A. Dikin, G.H. Dommett, K.M. Kohlhaas and E.J. Zimney, Graphene-based composite materials, Nat. 442 (2006), 282-286.
19. W.S. Hummers and R.E. Offeman, Preparation of graphitic oxide, J. Am. Chem. Soc. 80 (1958), 1339.
20. W. Zhang, Z.Y. Guo, D.Q. Huang, Z.M. Liu, X. Guo and H.Q. Zhong, Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide, Biomaterials 32 (2011), 8555-8561.
21. E.M. Kemper, W. Boogerd, I. Thuis, J.H. Beijnenand and O. Van Tellingen, Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? Cancer Treat Rev. 30 (2004), 415-423.
22. K. Yang, Y.J. Li, X.F. Tan, R. Peng and Z. Liu, Behavior and toxicity of graphene and its functionalized dervatives in biological systems, Small 9 (2013), 1492-1503.
23. D.Y. Lee, Z. Khatun, J.H. Lee, Y.K. Lee and I. In, Blood compatible graphene/heparin conjugate through noncovalent chemistry, Biomacromolecules 12 (2011), 336-341.
24. C.S. Shan, H.F. Yang, D.X. Han, Q.X. Zhang, A. Ivaska and L. Niu, Water-soluble graphene covalently functionalized by biocompatible poly-L-lysine, Langmuir 25 (2009), 12030-12033.