Identification of a novel 6′-N-aminoglycoside acetyltransferase, AAC(6′)-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 10, 2014, Pages 6324-6327

  Tada, Tatsuya ^a   Miyoshi Akiyama, Tohru ^a   Dahal, Rajan K ^c   Mishra, Shyam K ^c   Shimada, Kayo ^a   Ohara, Hiroshi ^b   Kirikae, Teruo ^a   Pokhrelc, Bharat M ^c  

^a Research Institute   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c TRIBHUVAN UNIVERSITY   (Nepal)

Author keywords

[No Author keywords available]

Indexed keywords

AAC(6') IAK PROTEIN; ACETYL COENZYME A; AMIKACIN; APRAMYCIN; BACTERIAL PROTEIN; DIBEKACIN; GENTAMICIN; HABEKACIN; ISEPAMICIN; KANAMYCIN; LIVIDOMYCIN; NEOMYCIN; NETILMICIN; SISOMICIN; TOBRAMYCIN; UNCLASSIFIED DRUG; ACYLTRANSFERASE; AMINOGLYCOSIDE ACETYLTRANSFERASE; ANTIINFECTIVE AGENT;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; ESCHERICHIA COLI; NUCLEOTIDE SEQUENCE; PROTEIN ACETYLATION; PROTEIN ANALYSIS; STENOTROPHOMONAS MALTOPHILIA; THIN LAYER CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; DIBEKACIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; NEOMYCIN; NETILMICIN; SISOMICIN; STENOTROPHOMONAS MALTOPHILIA; TOBRAMYCIN;

EID: 84907259454     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03354-14     Document Type: Article

References (17)

1. Brooke JS. 2012. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin. Microbiol. Rev. 25:2-41. http://dx.doi.org/10.1128/CMR.00019-11.
2. Denton M, Kerr KG. 1998. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin. Microbiol. Rev. 11:57-80.
3. Shaw KJ, Rather PN, Hare RS, Miller GH. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57:138-163.
4. Wachino J, Arakawa Y. 2012. Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gramnegative bacteria: an update. Drug Resist. Updat. 15:133-148. http://dx.doi.org/10.1016/j.drup.2012.05.001.
5. Ramirez MS, Tolmasky ME. 2010. Aminoglycoside modifying enzymes. Drug Resist. Updat. 13:151-171. http://dx.doi.org/10.1016/j.drup.2010.08.003.
6. Partridge SR, Thomas LC, Ginn AN, Wiklendt AM, Kyme P, Iredell JR. 2011. A novel gene cassette, aacA43, in a plasmid-borne class 1 integron. Antimicrob. Agents Chemother. 55:2979-2982. http://dx.doi.org/10.1128/AAC.01582-10.
7. Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T. 2013. Novel 6′-N-aminoglycoside acetyltransferase AAC(6′)-Iaj from a clinical isolate of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 57:96-100. http://dx.doi.org/10.1128/AAC.01105-12.
8. Kobayashi K, Hayashi I, Kouda S, Kato F, Fujiwara T, Kayama S, Hirakawa H, Itaha H, Ohge H, Gotoh N, Usui T, Matsubara A, Sugai M. 2013. Identification and characterization of a novel aac(6′)-Iag associated with the blaIMP-1-integron in a multidrug-resistant Pseudomonas aeruginosa. PLoS One 8:e70557. http://dx.doi.org/10.1371/journal.pone.0070557.
9. Clinical and Laboratory Standards Institute. 2012. Performance standards for antimicrobial susceptibility testing; 23rd informational supplement, M07-A9. Clinical and Laboratory Standards Institute, Wayne, PA.
10. Crossman LC, Gould VC, Dow JM, Vernikos GS, Okazaki A, Sebaihia M, Saunders D, Arrowsmith C, Carver T, Peters N, Adlem E, Kerhornou A, Lord A, Murphy L, Seeger K, Squares R, Rutter S, Quail MA, Rajandream MA, Harris D, Churcher C, Bentley SD, Parkhill J, Thomson NR, Avison MB. 2008. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol. 9:R74-2008-9-4-r74. http://dx.doi.org/10.1186/gb-2008-9-4-r74.
11. Lambert T, Ploy MC, Denis F, Courvalin P. 1999. Characterization of the chromosomal aac(6′)-Iz gene of Stenotrophomonas maltophilia. Antimicrob. Agents Chemother. 43:2366-2371.
12. Teran FJ, Suarez JE, Mendoza MC. 1991. Cloning, sequencing, and use as a molecular probe of a gene encoding an aminoglycoside 6′-Nacetyltransferase of broad substrate profile. Antimicrob. Agents Chemother. 35:714-719. http://dx.doi.org/10.1128/AAC.35.4.714.
13. Magnet S, Courvalin P, Lambert T. 1999. Activation of the cryptic aac(6′)-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion. J. Bacteriol. 181:6650-6655.
14. Chang LL, Chen HF, Chang CY, Lee TM, Wu WJ. 2004. Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia. J. Antimicrob. Chemother. 53:518-521. http://dx.doi.org/10.1093/jac/dkh094.
15. Gould VC, Okazaki A, Avison MB. 2013. Coordinate hyperproduction of SmeZ and SmeJK efflux pumps extends drug resistance in Stenotrophomonas maltophilia. Antimicrob. Agents Chemother. 57:655-657. http://dx.doi.org/10.1128/AAC.01020-12.
16. Huang YW, Hu RM, Yang TC. 2013. Role of the pcm-tolCsm operon in the multidrug resistance of Stenotrophomonas maltophilia. J. Antimicrob. Chemother. 68:1987-1993. http://dx.doi.org/10.1093/jac/dkt148.
17. Li XZ, Zhang L, McKay GA, Poole K. 2003. Role of the acetyltransferase AAC(6′)-Iz modifying enzyme in aminoglycoside resistance in Stenotrophomonas maltophilia. J. Antimicrob. Chemother. 51:803-811. http://dx.doi.org/10.1093/jac/dkg148.