Terminally modified, short phosphorothioate oligonucleotides as inhibitors of gene expression in cells

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 19, 2014, Pages 4694-4698

  Marzenell, Paul ^a,b   Hagen, Helen ^b   Blechinger, Jenny ^a   Erfle, Holger ^b   Mokhir, Andriy ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antisense; Chemical modification; Oligonucleotide; Phosphorothioate; Terminal modifier

Indexed keywords

ANTHRAQUINONE DERIVATIVE; CHOLIC ACID DERIVATIVE; LOCKED NUCLEIC ACID; MESSENGER RNA; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; STILBENE DERIVATIVE; PHOTOPROTEIN; RED FLUORESCENT PROTEIN;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SCREENING; GENE EXPRESSION; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MELTING POINT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HELA CELL LINE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MOLECULAR STRUCTURE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907226425     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.08.027     Document Type: Article

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